A traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux

A gastroesophageal reflux, refractory technology, applied in the field of medicine, can solve problems such as no intervention methods, and achieve the effect of improving small intestinal peristalsis, reducing expression, and increasing gastric emptying rate

Active Publication Date: 2022-07-12
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of reflux esophagitis in modern medicine mainly uses proton pump inhibitors to suppress acid, mosapride, etc. to promote gastrointestinal motility and symptomatic treatment. There is no effective intervention method. Obvious features and advantages

Method used

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  • A traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux
  • A traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux
  • A traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of the traditional Chinese medicine protocol comprises the following steps: weighing 15 g of Inula florida, 15 g of Pinellia chinensis, 15 g of Cyperus officinalis, 9 g of stalks, 15 g of raw loquat leaves, 15 g of dried tangerine peel, 15 g of Poria cocos, 30 g of sea octopus, and 30 g of fried radish seeds , put it into a 5000ml round-bottomed flask, heat 3000ml of water for 3 extractions: the first time, 1000ml of hot water was added to extract and boil for 2 hours, then cooled and suctioned, and the second time was added with 1000ml of hot water to extract and boiled for 1 hour, and then cooled and suctioned. Add 1000ml of hot water to extract and boil for 1 hour, then cool and suction filtration, combine the filtrate, and pump it into a rotary evaporator for concentration to a density of 1.25-1.30g / ml to obtain a traditional Chinese medicine compound combination for the treatment of refractory gastroesophageal reflux. extracts.

[0047] To determine...

Embodiment 2

[0070] 1. Diagnostic criteria

[0071] 1.1 Disease diagnostic criteria

[0072] 1.1.1 Symptomatic diagnostic criteria: According to the consensus opinion of digestive experts in 2014, the clinical manifestations are typical symptoms (reflux and heartburn), or atypical symptoms (belching, burning sensation in the upper abdomen, chest pain excluding cardiac factors, epigastric pain, etc.) , or extraesophageal syndrome (throat discomfort, cough, asthma, tooth erosion, etc.) can be considered as gastroesophageal reflux disease.

[0073] 1.1.2 Diagnostic criteria of TCM syndromes:

[0074] Referring to the "gallbladder heat invading the stomach" syndrome in "Consensus Opinions on TCM Diagnosis and Treatment of Gastroesophageal Reflux Disease (2009)", the criteria for judging the syndrome are as follows: ① bitterness in the mouth and dry throat; ② heartburn. Secondary symptoms: ① retrosternal burning pain; ② chest pain, back pain; ③ acid regurgitation; ④ belching reflux;

[0075] S...

Embodiment 3

[0132] Typical cases

[0133] Patient Wan Moumou, male, 59 years old

[0134] First consultation time: 2020-4-15

[0135] Due to repeated acid reflux, belching, and hiccups for more than a month, he underwent gastroscopy at Xinhua Hospital Affiliated to Shanghai Jiaotong University on November 30, 2019 (examination number: 15121166696) and showed: "Reflux esophagitis (LA-A) , erosive gastritis", gastroscopic pathology showed: "chronic inflammation of the gastric antrum: ++, intestinal metaplasia of the gastric antrum: focus +"; gastroscopic diagnosis: chronic moderate non-atrophic gastritis of the gastric antrum, mild focal mild intestinal metaplasia . The patient was treated with oral antacids and mosapride without significant improvement.

[0136] At the time of consultation, the patient experienced acid regurgitation, repeated episodes of heartburn, accompanied by belching, satisfied food, and had a bowel movement once a day, which was shapeless, sticky and uncomfortable...

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Abstract

The invention discloses a traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux. 10-20 servings, 4-14 servings of stalks, 10-20 servings of raw loquat leaves, 10-20 servings of dried tangerine peel, 10-20 servings of Poria, 20-40 servings of sea octopus, and 20-40 servings of fried radish. The traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux provided by the invention has anti-inflammatory effect, can improve the gastric emptying rate of rabbits, improve the peristalsis of small intestines of rabbits, improve the propulsion rate of small intestines, and at the same time, can reduce the internalization of gastric tissue. The expression of inflammatory factors has no adverse reactions, no obvious toxic and side effects, and is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux. Background technique [0002] Reflux esophagitis refers to gastroesophageal reflux disease accompanied by esophageal mucosa and other pathological damage, mainly due to the reflux of gastric and duodenal contents, especially acidic gastric juice and bile to the esophagus, causing other inflammation of the esophageal mucosa. , erosion, ulcer caused. These include lower esophageal sphincter pressure, decreased esophageal body clearance, weakened esophageal body peristalsis, decreased reflux clearance, decreased esophageal tissue resistance, and decreased protection against pepsin and H+ entering the esophagus. It is also the main cause of mucosal inflammation. At present, the treatment of reflux esophagitis in modern medicine is mainly to use proton pump inhibitors to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61P1/04A61K35/618
CPCA61K36/28A61K36/8888A61K36/8905A61K36/535A61K36/73A61K36/752A61K36/076A61K35/618A61K36/31A61P1/04A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 孙大志庞涛岳小强叶敏矫健鹏王晓航张璇刘咏英裴蓓张慈安
Owner SHANGHAI CHANGZHENG HOSPITAL
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