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Traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux

A gastroesophageal reflux, refractory technology, applied in the field of medicine, can solve problems such as no intervention methods

Active Publication Date: 2021-04-30
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of reflux esophagitis in modern medicine mainly uses proton pump inhibitors to suppress acid, mosapride, etc. to promote gastrointestinal motility and symptomatic treatment. There is no effective intervention method. Obvious features and advantages

Method used

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  • Traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux
  • Traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux
  • Traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of the agreement prescription of traditional Chinese medicine includes the following steps: weighing 15g of Inula chinensis, 15g of Pinellia chinensis, 15g of Cyperus cyperi, 9g of Perilla stalk, 15g of raw loquat leaf, 15g of tangerine peel, 15g of Poria cocos, 30g of sea octopus, and 30g of fried radish. , put it into a 5000ml round-bottomed flask, heat 3000ml of water and extract 3 times: add 1000ml of hot water for the first time to extract and boil for 2 hours, then cool and suction filter, add 1000ml of hot water for the second time, extract and boil for 1 hour, then cool and suction filter, and the third time Add hot water 1000ml at a time, extract and boil for 1 hour, then cool and filter, combine the filtrate, pump it into a rotary evaporator and concentrate until the density is 1.25-1.30g / ml, and obtain a compound combination of traditional Chinese medicine for the treatment of refractory gastroesophageal reflux extracts.

[0047] Measure the e...

Embodiment 2

[0070] 1. Diagnostic criteria

[0071] 1.1 Disease diagnostic criteria

[0072] 1.1.1 Symptomatic diagnostic criteria: According to the 2014 consensus opinion of gastroenterology experts, the clinical manifestations are typical symptoms (reflux and heartburn), or atypical symptoms (belching, burning sensation in the upper abdomen, chest pain excluding cardiac factors, upper abdominal pain, etc.) , or extraesophageal syndrome (throat discomfort, cough, asthma, dental erosion, etc.) may be considered gastroesophageal reflux disease.

[0073] 1.1.2 TCM syndrome diagnostic criteria:

[0074] Refer to the syndrome of "gale-heat invading the stomach" in the "Consensus Opinions on the Diagnosis and Treatment of Gastroesophageal Reflux Disease in Traditional Chinese Medicine (2009)", the criteria for judging syndromes: main symptoms: ①bitter mouth and dry throat; ②heartburn. Secondary symptoms: ①retrosternal burning pain; ②chest pain, back pain; ③acid regurgitation; ④belching reflux; ...

Embodiment 3

[0132] Typical cases

[0133] Patient Wan Moumou, male, 59 years old

[0134] First visit time: 2020-4-15

[0135] Due to repeated acid reflux, belching, and hiccups for more than a month, he went to Xinhua Hospital Affiliated to Shanghai Jiaotong University for gastroscopy on November 30, 2019 (examination number: 15121166696) and showed: "reflux esophagitis (LA-A) , erosive antral gastritis", gastroscopy pathology showed: "chronic inflammation of gastric antrum: ++, gastric antrum intestinal metaplasia: foci +"; gastroscopy diagnosis: gastric antrum chronic moderate non-atrophic gastritis, focal mild intestinal metaplasia . Oral antacids and mosapride and other treatments showed no significant improvement and went to the doctor.

[0136] When visiting the doctor, acid regurgitation and heartburn recurred, accompanied by belching, taking food intake, defecating once a day, shapeless, sticky and uncomfortable, pale red tongue, thin yellow greasy fur, and slippery pulse. Th...

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Abstract

The invention discloses a traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux. The traditional Chinese medicine compound composition is prepared from the following components in parts by weight: 10-20 parts of inula flower, 10-20 parts of processed rhizoma pinelliae, 10-20 parts of processed rhizoma cyperi, 4-14 parts of caulis perllae, 10-20 parts of raw folium eriobotryae, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of poria cocos, 20-40 parts of cuttlebone and 20-40 parts of fried semen raphani. The traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux provided by the invention has an anti-inflammatory effect, can improve the gastric emptying rate of rabbits, improve the small intestine peristalsis of the rabbits and improve the small intestine propulsion rate, can reduce the expression of inflammatory factors in gastric tissues, has no adverse reaction and no obvious toxic or side effect, and is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a compound traditional Chinese medicine composition for treating refractory gastroesophageal reflux. Background technique [0002] Reflux esophagitis refers to gastroesophageal reflux disease accompanied by esophageal mucosa and other pathological lesions, mainly caused by the reflux of stomach and duodenal contents, especially acidic gastric juice and bile, into the esophagus, causing other inflammations of the esophageal mucosa , erosion, ulcer caused. These include lower esophageal sphincter pressure, decreased esophageal body clearance function, weakened esophageal body peristalsis, decreased reflux clearance, decreased esophageal tissue resistance, and decreased protection against pepsin and H+ that enter the esophagus, etc. It is also the main cause of mucous membrane inflammation. At present, the treatment of reflux esophagitis in modern medicine mainly uses proton pum...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P1/04A61K35/618
CPCA61K36/28A61K36/8888A61K36/8905A61K36/535A61K36/73A61K36/752A61K36/076A61K35/618A61K36/31A61P1/04A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 孙大志庞涛岳小强叶敏矫健鹏王晓航张璇刘咏英裴蓓张慈安
Owner SHANGHAI CHANGZHENG HOSPITAL
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