60 results about "Random coil" patented technology

Percutaneous interbody spine fusion devices are provided. These devices may have a number of different designs and exemplary features. One device consists of a single rotating hollow cam cage with perforations (with or without fixation anchors) and a delivery tool. Another device consists of a counter-rotating cam cage (with or without fixation anchors) and a delivery tool. A third device consists of an expanding cam with anchors and delivery tool; this device may consist of a single expanding cam or a series of expanding cams. A delivery tool is included. A fourth device consists of a spring cage; this device may be a stand-alone device, can be combined with expanding cam device, and may be incorporated into a cage. A delivery tool is included. This spring cage may or may not have fixation anchors. A fifth device consists of a random coil support device that can be used as a nuclear or spine fracture support device; a delivery tool is included. A sixth device consists of a directional ribbon strip coil device and delivery tool. Also provided is a percutaneous off-angle bone stapling/nailing fixation device.

The present invention relates to a display comprising at least one substrate, at least one electrically conductive layer and at least one electronically modulated imaging layer, wherein the electronically modulated imaging layer comprises a self-assembled, close-packed, ordered monolayer of domains of electrically modulated material in a random coil fixed polymer matrix and filler.

The invention discloses a macromolecular microcarrier and a preparation method thereof, belonging to the technical field of biomedicine. The preparation method comprises the following steps of: splitting a silk solution and a drug solution into micrometer grade liquid drops with core-shell structures under the action of a high-voltage electric field by adopting a coaxial high-voltage electrostatic technology and a freeze drying method; concreting through liquid nitrogen, and then preparing the microcarrier which is difficult to dissolve in water through freeze drying. The microcarrier is in the shape of a microsphere with the core-shell structure, and the diameter of the microsphere is 100-500 micrometers; the shell of the microcarrier comprises the components of silk fibroin; the random-coil conformation of silk fibroin molecules is 80-90 percent; the shell is in a porous structure, and an aperture is 5-20 micrometers; and a core of the microcarrier comprises the components of water-soluble drugs. The silk microcarrier has extensive application prospect in the fields of cell culture, drug release, and the like.

The invention discloses a preparation method of goat cheese protein source antibacterial peptide. The preparation method comprises the following steps: performing enzymolysis on the goat cheese protein by use of papain; separating and desalting the zymolyte by use of macroporous nonpolar resin; purifying by semi-preparation gel permeation chromatograph; and performing freeze drying to obtain goat cheese protein source antibacterial peptide powder. The result of the trial experiment on antibacterial function carried out by the applicant indicates that the molecular weight of the prepared goat cheese protein source antibacterial peptide is below 3,000, and the goat cheese protein source antibacterial peptide is easy to absorb and utilize; the secondary structure of the obtained goat cheese protein source antibacterial peptide is mainly a random coil; and the goat cheese protein source antibacterial peptide is a nontoxic green natural antibacterial peptide, has good antibacterial properties on escherichia coli, staphylococcus aureus, salmonella and the like, and has a remarkably broad application prospect in the preservation of milk and dairy products, cosmetics and other food.

The invention belongs to the technical field of silk protein treatment and particularly relates to ionic liquid solution of regenerated silk protein and a preparation method thereof. The preparation method comprises a step of freeze-drying dewatering and a step of dissolving under reduced pressure and particularly comprises: uniformly mixing a silk or silk protein material and ionic liquid, freezing under a liquid nitrogen condition, and dewatering in a freezer dryer; and heating the dried mixture in an oil bath with stirring, removing air bubbles and possible residual water from the system under a reduced pressure to prepare the ionic liquid solution of the silk protein. The concentration of the final product is 1 to 35 weight percent, and the silk protein conformation in the solution ismainly random coil. In the invention, nontoxic, non-volatile and easily-recoverable ionic liquid is used as a solvent, so the method is quick, simple and easy; and the room-temperature storage performance under a water-free condition of the solution of the silk protein is high, and all physical and chemical indexes of the solution can be kept stable for a long time.

The invention discloses an active polypeptide capable of promoting osteogenesis and inhibiting osteoclast and application of the active polypeptide. N-terminal serine is phosphorylated on the basis ofPTH1-34, and three repeated sequences of glutamic acid or aspartic acid are introduced at a C terminal; the sequence of the polypeptide is shown in SEQ ID NO:1 or SEQ ID NO:2, and the polypeptide hasosteoinductive activity similar to BMP2 and an osteoclast inhibiting effect similar to parathyroid hormones (PTH). Random coils of the polypeptide can be avoided by bonding the C-terminal repeated sequences of the polypeptide to the surface of a calcium phosphate material or a material with a calcium phosphate coating, no addition of organic reagents is needed, and therefore the activity of the polypeptide is protected effectively; furthermore, slow controlled release can be achieved through cleavage of peptide bonds, and long-term intermittent injection of the PTH1-34 can be avoided, so thatthe injection pain of patients is reduced, and effects of osteoblast promotion and osteoporosis inhibition are achieved; a conventional viewpoint that the PTH1-34 cannot be administered locally is changed.

A polymer has a fluorescent dye sensitive to a hydrophobic environment. When a pH around the polymer decreases within a range of pH of equal to or greater than 5.5 and less than 7.4, and a secondary structure of the polymer changes from a random coil to a helix.

The invention discloses photo-curable silk fibroin hydrogel and a preparation method thereof. The photo-curable silk fibroin hydrogel is prepared by: adding riboflavin and horse radish peroxidase intosilk fibroin solution that acts as a raw material, introducing oxygen continuously under ultraviolet irradiation and room temperature, inducing groups in silk fibroin macromolecules to chemically crosslink, and allowing gelling. The silk fibroin in the photo-curable hydrogel provided herein is mainly of random coil; the photo-curable hydrogel has high light transmittance, high compressive strength and high elasticity and is applicable to tissue repair materials.

The invention discloses an electromagnetic heating coil plate, comprising a coil plate bracket provided with a plurality of coiling parts. A magnetic bar is arranged on the back surface of each coiling part; an interval cavity is reserved between the adjacent coiling parts; a plurality of baffle plates are arranged on the coiling parts; a coil groove is formed between the adjacent baffle plates; the coil grooves on the coiling parts commonly form a concentric circle structure; and a varnished wire is coiled on each coil groove and coils from one circle of the coil groove to the adjacent circle of the coil groove in any internal cavity. Accordingly, the coiling parts on the coil plate bracket can be arranged in a consistent structure, so as to greatly simplify the structure of the coil plate bracket and a structure of a preparation die. When a producer coils, the random coiling from one circle of the coil groove to the adjacent circle of the coil groove is realized in any one of the interval cavities between the coiling parts. The electromagnetic heating coil plate is flexible and convenient.

The invention relates separation preparation and application of an Arcainflata Reeve oxidation-resistant active peptide. The separation preparation method comprises the following steps: peeling and cleaning Arcainflata Reeve, carrying out tissue homogenization, carrying out hydrolysis technique screening and optimization, centrifugating, taking the supernate, and carrying out freeze-drying to obtain an active polypeptide component; and sequentially carrying out ultrafiltration interception concentration, ion-exchange chromatography, gel filtration and high-efficiency exclusion chromatography on the active component to finally obtain the oxidation-resistant active polypeptide with the purity of 99%. Multiple modern protein purification techniques are creatively utilized to separate the active polypeptide with definite material basis from Arcainflata Reeve hydrolysate; the molecular weight of the active polypeptide is 17578.31Da; and the active polypeptide contains the following secondary structures: 40.8% of alpha-spiral, 24.7% of beta-fold, 15.9% of beta-corner and 18.6% of random coil. The polypeptide has obvious oxidation-resistant activity; the in-vitro removal DPPH, ABTS and hydroxy free radical IC50 values are respectively 3.89, 0.22 and 10.77 mg/ml; and the polypeptide can prolong the average life of the Caenorhabditis elegans by 18.29%. Therefore, the active peptide can be used for development and application of antioxidants, medicinal cosmetics or health products.

The invention provides menadione sodium bisulfite (MSB), namely a drug with the functions of preventing and treating Alzheimer's disease. It is found in research that menadione sodium bisulfite has the functions of obviously inhibiting aggregation of beta-amyloid protein1-42 (Abeta42), namely pathogenic protein of Alzheimer's disease, retarding conversion of a secondary structure of beta-amyloid protein1-42 from random coils into beta lamellas during aggregation, weakening the cytomembrane destruction capability of beta-amyloid protein1-42 toxicity congeries, inhibiting aggregation of beta-amyloid protein1-42 in cells, obviously prolonging the life of nematode in a caenorhabditis elegans AD model, achieving high safety performance and the like. It is disclosed that menadione sodium bisulfite can be applied to preparation of drugs with the functions of preventing and/or treating Alzheimer's disease.