The invention discloses a traditional Chinese medicine composition for treatment of cardiovascular infarction syndrome and a preparation method thereof, wherein the traditional Chinese medicine composition of the invention is mainly composed by the following raw material medicines: salvia miltiorrhiza, szechuan lovage rhizome, dried orange peel, costustoot, curcuma aromatica, nutgrass galingale rhizome, peach kernel, safflower, pangolin, rhubarb, benzoin, holy basil, immature bitter orange, cinnamon, medicinal evodia fruit, cassia twig, rhizoma galangae, pericarpium zanthoxyli, tambac, Szechwan chinaberry fruit, garden burnet root, cattail pollen, rosewood heart wood, rhizoma bletillae, lotus rhizome node, rhizoma corydalis, frankincense, myrrh, motherwort, herba lycopi, achyranthes, suberect spatholobus stem, resina draconis, common burreed rhizome, curcuma zedoary, pangolin, storax, borneol, toad venom, camphor, grassleaf sweetflag rhizome, prepared rehmannia root, angelica, white paeony root, gizzard-membrane of chicken, turtle shell and tortoise plastron. The traditional Chinese medicine composition of the invention can be prepared into any common oral liquid preparation according to the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of precordial pain, angina, nausea and vomiting, apogee sweating, heart failure and even dyspnea, shock, faint and the like caused by cardiovascular infarction, has accurate clinical effect and obvious curative effect, and takes effect quickly. The traditional Chinese medicine composition of the invention basically adopts medicine-food homologous drugs regulated by National Formulary to composite, thereby having the advantages of low cost, almost no toxic side effect and the like.