The invention provides a preparation method of radix ginseng and rhizoma pinelliae liquor. The radix ginseng and rhizoma pinelliae liquor is prepared from the following active raw material componentsin parts by weight: 8-10 parts of radix ginseng, 15-18 parts of rhizoma pinelliae, 8-10 parts of rhizoma zingiberis, 15-18 parts of radix scutellariae, 8-10 parts of radix et rhizoma glycyrrhizae, 3-5parts of goldthread roots, 8-10 parts of jujubes fruits, 10-15 parts of arillus longan and 400-500 parts of Baijiu. The preparation method comprises the following steps: mashing the radix ginseng, the rhizoma pinelliae, the rhizoma zingiberis, the radix scutellariae, the radix et rhizoma glycyrrhizae, the goldthread roots, the jujubes fruits and radix angelicae sinensis together, wrapping the powder with cloth, and putting the cloth into a container; injecting the Baijiu into the container, and allowing the container to stand for 5-7 days; and adding 400-500 parts of cold boiled water into the container, performing uniform mixing, taking out the liquor, and putting the liquor into a bottle for standby use. The radix ginseng and rhizoma pinelliae liquor is simple in preparation, can be preserved for a long term, is free of any additive, is suitable for the people with stomach qi disorder, has the effects of dispelling wind and eliminating dampness, invigorating qi and dredging collaterals, relaxing muscles and tendons and promoting blood circulation as well as strengthening the spleen and warming the kidneys, and is used for treating arthralgia due to wind cold and dampness, arthralgia and myalgia, deficiency-cold in spleen and stomach, deficiency of the kidneys, soreness of the waist, female qi deficiency and anemia and the like.