31 results about "Photoacoustic Techniques" patented technology

The invention relates to a method and device for observing photoacoustic imaging in a single-array element and multi-angle mode based on compressive sensing, belonging to the technical field of photoacoustic imaging and aiming at solving the problems of serious artefact, deformed images, high hardware cost and poor lateral resolution of images in the existing photoacoustic technology for imaging biological tissues. The method comprises the following steps: leading a pulsed laser to emit pulsed laser beams, irradiating the pulsed laser beams upon the biological tissues by using an optical maskto generate photoacoustic signals, observing and acquiring the photoacoustic signals synchronously by using two angled single array element ultrasonic probes, amplifying the photoacoustic signals, sending the photoacoustic signals to an A / D (analog to digital) converter, sampling uniformly, inputting acquired photoacoustic image data into a computer by using an FPGA (field programmable gate array), and reconstructing and fusing photoacoustic images by using the computer. Due to the adoption of a hardware platform and a processing mechanism which is rapidly constructed based on the compressivesensing algorithm by using the single array element ultrasonic probes to acquire the photoacoustic signals in parallel, the high resolution of the images are ensured on the premise that the sampled data are reduced and the acquiring time is shortened. The device for imaging is easy to operate.

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a first image obtained when the photoacoustic probe is in active (absorbing or ON) state and a second image obtained when the photoacoustic probe is in an inactive (less-absorbing or OFF) state. Subtraction of the second image from the first image is used to obtain the RS-PAT image.

The invention provides an analyzing and processing method and device for a tumor image. The method comprises the step of combining hardness information of ultrasonic imaging and blood oxygen information provided by photoacoustic imaging for analysis of the tumor image. In the specific embodiment of the invention, the hardness information of ultrasonic imaging and the blood oxygen information provided by photoacoustic imaging are combined for analysis of the tumor image, critical function and molecular imaging information provided by the photoacoustic technique can be importantly complementarywith tissue morphology and structure information provided by the ultrasonic technique, and overall observation of tumor structure and function is realized through combination of the photoacoustic technique and the ultrasonic technique.

The invention provides a high-resolution photoacoustic microscopic imaging identity recognition system and a recognition method thereof. The high-resolution photoacoustic microscopic imaging identity recognition system comprises an excitation light source, a detection light source, a first beam splitter, a second beam splitter, a two-dimensional scanning galvanometer, a scanning lens, a compression lens, a flat plate, a lower glass plate, a vibration film, an upper glass plate, a photoelectric detector and a central processing unit. The high-resolution photoacoustic microscopic imaging identity recognition system perform imaging on a space geometric structure of a subcutaneous blood vessel network by using a photoacoustic technology, the spatial resolution can reach up to hundreds of nanometers, and a high-precision two-dimensional or three-dimensional blood vessel network structure image can enable the accuracy of identity recognition to be greatly improved.

The invention relates to a method and device for observing photoacoustic imaging in a single-array element and multi-angle mode based on compressive sensing, belonging to the technical field of photoacoustic imaging and aiming at solving the problems of serious artefact, deformed images, high hardware cost and poor lateral resolution of images in the existing photoacoustic technology for imaging biological tissues. The method comprises the following steps: leading a pulsed laser to emit pulsed laser beams, irradiating the pulsed laser beams upon the biological tissues by using an optical mask to generate photoacoustic signals, observing and acquiring the photoacoustic signals synchronously by using two angled single array element ultrasonic probes, amplifying the photoacoustic signals, sending the photoacoustic signals to an A / D (analog to digital) converter, sampling uniformly, inputting acquired photoacoustic image data into a computer by using an FPGA (field programmable gate array), and reconstructing and fusing photoacoustic images by using the computer. Due to the adoption of a hardware platform and a processing mechanism which is rapidly constructed based on the compressive sensing algorithm by using the single array element ultrasonic probes to acquire the photoacoustic signals in parallel, the high resolution of the images are ensured on the premise that the sampled data are reduced and the acquiring time is shortened. The device for imaging is easy to operate.

The invention discloses a device and method for rapid detection of food and drug component content by photoacoustic combined spectroscopy, including a light source radiation unit, a detection room unit, a spectrum splitting unit, a photoacoustic detection unit, a signal processing unit, a signal control unit and Signal display unit. The present invention has the following beneficial effects: on the one hand, it is convenient and fast to use the spectral method to find the characteristic wavelength, which greatly saves and facilitates the selection of the characteristic wavelength in the photoacoustic detection method, so that the detection efficiency is greatly improved; on the other hand, the use of photoacoustic technology The qualitative and quantitative detection of the measured substance avoids the interference caused by the multi-component scattered light in the measured substance in the spectroscopic method, so that the detection accuracy is greatly improved.

The invention provides an acousto-optical alkalinity-acidity imaging method and device based on development difference of reagents. The method comprises the steps of dissolving acid-base indicator in the straight alcohol solution to serve as acousto-optical alkalinity-acidity detection reagent; recording the intensity of the acousto-optical signals of the alkalinity-acidity detection reagent at different PH values by using the acousto-optical detection system, and drawing the acousto-optical alkalinity-acidity detection standard curve; dyeing the object to be detected by the alkalinity-acidity detection reagent, measuring the intensity of the acousto-optical signals of the object to be detected before and after dyeing, processing the acousto-optical image by calculating, determining the alkalinity-acidity of the object to be detected compared with the standard curve, and reconstructing the acousto-optical image expressing the alkalinity-acidity distribution by using a back projection algorism. The device implementing the method is composed of a laser emitting assembly, an ultrasonic detection assembly, a data acquisition and transmission assembly, a computer, and an image processing software. The method and the device have high sensitivity, and can be used for measuring not only the alkalinity-acidity of liquid substances, but also the alkalinity-acidity of semisolid and solidsubstances.

The invention discloses a handheld food safety detection device. The device comprises four parts, namely an stimulation-detection integrated probe, a signal processing unit, a control unit and a display unit, wherein the stimulation-detection integrated probe sequentially consists of a laser diode, a collimating lens, a focusing lens and a multi-ring ultrasonic detector from top to bottom; the signal processing unit is formed by sequentially electrically connecting a signal amplifying circuit, an electronic switch, a phase adjusting circuit and an A / D (Analog to Digital) converting circuit; the control unit consists of an embedded system, a laser diode driving circuit and a synchronous trigger circuit; the display circuit consists of an LCD display screen with a touch screen function. Compared with other techniques and devices, the handheld food safety detection device has the advantages that by utilizing a photo-acoustic technique, an embedded control design as well as an ultrasound detection integrated probe stimulated by virtue of the laser diode, the detection device is high in detection accuracy and strong in applicability and is convenient to use.

The invention provides a bowl-type photoacoustic imaging breast scanning device and a scanning method thereof. The bowl-type photoacoustic imaging breast scanning device comprises a bowl-type photoacoustic probe, wherein the bowl-type photoacoustic probe comprises a bowl-type outer support, a laser beam expander is arranged outside the outer support, the inner wall of the outer support is an inner diffuse reflection cavity wall, and an ultrasonic transducer is arranged on the inner diffuse reflection cavity wall. During scanning, the a ultrasonic coupling agent is injected into the bowl-type photoacoustic probe, a breast to be detected is put in the bowl-type photoacoustic probe, the light from a laser is introduced into the bowl-type photoacoustic probe through a reflecting mirror and expanded, the photoacoustic signals at different angles are detected by the ultrasonic transducer and transmitted to a processor where a three-dimensional photoacoustic image of the breast is formed. By the photoacoustic imaging technique in combination with the routine ultrasonic imaging technique, the non-invasive portable photoacoustic imaging breast scanning device can rapidly scan and image breasts with high contrast and high precision and depth and achieve non-invasive and non-radioactive early diagnosis and treatment of breast cancer.

The invention discloses a method for inducing double nonlinearity photo-acoustic signals trough a single laser pulse. The method comprises the steps that the single laser pulse is focused to an object to be measured; when the width of the laser pulse is larger than pressure relaxation time of the object to be measured, the object to be measured produces double nonlinearity photo-acoustic signals. The invention further discloses a device for inducing the double nonlinearity photo-acoustic signals trough the single laser pulse. The device comprises a laser pulse output device capable of adjusting width, a focusing lens and an ultrasonic sensor. The laser pulse output device is used for producing a laser pulse, the focusing lens focuses the laser pulse to the object to be measured, the focusing lens is arranged in a cavity of the ultrasonic sensor, the object to be measured is arranged at a port of the cavity of the ultrasonic sensor, and the ultrasonic sensor is used for detecting the double nonlinearity photo-acoustic signals produced through induction of the laser pulse. The problem that a laser pulse cannot produce two nonlinearity photo-acoustic signals in the prior art can be solved, and the photoaccoustic detection and imaging technology sensitivity and resolution ratio can be further improved compared with traditional nonlinearity photo-acoustic technology.

The invention provides a multimode imaging detection system for skin disease, characterized in that a supercontinuum laser is adopted, different wavelengths for specific skin tissues are selected to acquire hyperspectral and high-resolution confocal imaging, simultaneously the characteristic of deep depth of photoacoustic technique imaging is combined, and system integration of a hyperspectral imaging technique, a reflection type confocal imaging technique and a photoacoustic imaging technique is carried out to form the multimode optical imaging system. The multimode imaging detection system repairs the shortcoming of single-mode imaging in skin diagnosis, and compared with the single-modal technique, the multimode technique provides more complete information, improves the sensibility, accuracy and specificity in skin disease diagnosis, realizes hyperspectral, high-resolution and high-speed multimode optical molecular images for deep level skin disease diagnosis, provides a new technical means for diagnosis and clinical research on skin disease, is favorable for improving the diagnosis level of skin disease, and simultaneously can guide operation on skin disease and provide objective evaluation on medication of skin disease.

The invention relates to a detection method of a microfluidic chip based on a photoacoustic technique and a device thereof. The detection method comprises the following steps of: adopting the microfluidic chip consisting of an incident light generating unit A, a photoacoustic signal detection unit B, a signal processing and data conversion unit C, a computer processing unit D and a platform capable of translating in double directions of X direction and Y direction; adding pretreated samples to be detected into the microfluidic chip for electrophoresis, emitting signals by the computer processing unit according to commands, and controlling electrophoresis and high voltage after being converted by a single chip microprocessor D / A; under the effect of electric field, separating samples with different mobility according to different mobility, absorbing light power by the samples to generate photoacoustic signals by a spot detection window, collecting photoacoustic signals by an ultrasonicsensor, converting the photoacoustic signals into electric signals, converting the photoacoustic signals received by the sensor into digital signals by an analog-to-digital converter and being capable of determining the types and properties of the samples to be detected after being processed by signals of the computer. The detection method has the advantages of high sensitivity, low cost and convenient operation.

The invention relates to synthesis of a cuprous oxide material and application thereof in sulfide detection using photoacoustic technique. The cuprous oxide material is prepared by the following steps: (1) dissolving polyvinylpyrrolidone in nitromethylpyrrolidone to obtain a polyvinylpyrrolidone solution; (2) adding copper nitrate salt into the polyvinylpyrrolidone solution prepared in the step (1), and stirring for dissolution to obtain a PVP-Cu precursor; (3) heating the PVP-Cu precursor, reacting and purifying to obtain a precipitate; and dispersing the precipitate in water to obtain the target product. Moreover, the prepared cuprous oxide material can be applied in a brand new way to sulfide detection using photoacoustic technique. Compared with the prior art, the preparation method issimple with high selectivity and high sensitivity; and the prepared cuprous oxide material can be used for creating a nano photoacoustic probe to detect hydrogen sulfide gas in solution and living body, and has a broad application prospect in the field of biomedicine.

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a first image obtained when the photoacoustic probe is in active (absorbing or ON) state and a second image obtained when the photoacoustic probe is in an inactive (less-absorbing or OFF) state. Subtraction of the second image from the first image is used to obtain the RS-PAT image.