31 results about "Nerve gases" patented technology

The present invention provides methods for the large-scale production of recombinant butyrylcholinesterase fused to human serum albumin in cell culture, and in the milk and / or urine of transgenic mammals. The recombinant butyrylcholinesterase-albumin fusion protein of this invention can be used to treat and / or prevent organophosphate pesticide poisoning, nerve gas poisoning, cocaine intoxication, and succinylcholine-induced apnea.

A family protective shelter which can be erected quickly inside in a home living room, family room, patio, or on an outside lawn area. This dome tent enclosure is designed of clear plastic sheet material which is impervious to gases used to conduct chemical warfare (such as nerve gas, mustard gas, serin, cyanide, and the like) dispersed biohazard aerosol compounds (such as anthrax, smallpox, polio, bacteria, viruses, or fungi), or other atmospheric toxins, such as those from a nuclear fallout. This protective “pop-up”, external frame enclosure will be sized to house at least two adults comfortably (6×9×7 high inside, up to about 10×18′×7′ high), will incorporate a zip-lock entrance / egress isolation portal chamber, and will communicate to the outside world through combat gas mask filters, plus phone, computer and electrical outlet feed-through, and perhaps a water trap coupling. The invention can keep a family of 1 to 10 (with a larger size) relatively isolated and safe from the harmful effects of a chemical biohazard, or nuclear fallout enemy attack for a matter of hours up to several days. The portal chamber can also connect together additional modules.

A method and apparatus architecture for detecting gases, particularly hazardous gases which should be detected in miniscule amounts. High sensitivity detection of chemical warfare agents (CWAs) is set forth with very low probability of false positives (PFP) by the use of an innovative laser-photoacoustic spectrometer (L-PAS). Detection of diisopropyl methylphosphonate (DIMP), a decomposition product of Sarin and a relatively harmless surrogate for the nerve gases, is made in the presence of other gases that are expected to be interferences in an urban setting. Detection sensitivity for DIMP in the presence of these interferences of better than 0.45 ppb, which satisfies current homeland and military security requirements is shown as well as the first analysis of optical techniques for the detection of chemical warfare agents (CWAs) and toxic industrial chemicals (TICs) in real world conditions.

An oxidizing liquid (20), such as hydrogen peroxide, is vaporized (18) and the vapor is used to deactivate nerve gas, blistering gas, or other biologically active substances such as pathogens, biotoxins, and prions. A second chemical compound (42) in vapor, mist, or fog form is used in conjunction with the oxidizing vapor. In one embodiment, the second chemical preconditions the biologically active substances to be deactivated more efficiently by the oxidizing vapor. In another embodiment, the second chemical boosts the reactivity of the oxidizing vapor. In another embodiment, the other chemical reacts with the oxidizing vapor to form an intermediate compound that deactivates at least some of the biologically active substances.

Provided herein are compositions and related methods for delivering an organophosphatase to the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor) and an organophosphatase. In some embodiments, the compositions described herein are used to treat a subject suffering from or at high risk of exposure to an organophosphate (e.g., a nerve gas).

A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc. form or in a tablet, pill, etc. form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.

The present disclosure relates to systems, methods, and formulations for the pulmonary administration of one or more therapeutic agents, in dry powder form, in a single, large dose quantity. These formulations, methods, and systems are useful in the treatment of patients suffering from toxic or harmful gas exposure, such as nerve gas exposure, as well as in the treatment of patients suffering from diseases of the pulmonary system, including tuberculosis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).

Air decontamination method and device designed for bioterrorism, nerve gas, toxic mold, small pox, Ebola, anthrax and other agents require built in air sampling, rapid filter changes and the ability to use a mobile, transportable and connectable system in positive mode to push contaminates away or in negative mode to contain a toxin from spreading. This application combines features in respirators, industrial and hospital grade air filtration with the ability to provide air testing to guide the connection of the device with other treatment modules or existing HVAC and other equipment. With this new flexibility, ozone, UV, absorption, Thermal destruction, filters and liquid chemical neutralization can be manually or automatically adapted for emergency response to both daily airborne contamination and military grade terrorist threats of airborne contamination. The air decontamination units may be used to decontaminate the air after industrial and medical contaminations and terrorist biological, chemical and radiological attacks, for example. Mobile isolation units, and methods of decontaminating rooms, are disclosed, as well as Well as infection control and emergency response usage as an emergency clean air supply when connected to escape hoods, decon tents, or containment barriers to protect structures from homes to business from outside toxic agents. The unit can be powered by normal AC, 120 volts or 240 or be adapted to battery or field power supply units.

A composite textile article for garments which are useful as a barrier for chemical and biological contaminants, such as nerve gas and infectious microorganisms from a surrounding atmosphere. The composite textile article has a sheet of a water vapor permeable central textile fabric composed of polymeric multilobal fibers, having a central core and T-shaped lobes projecting therefrom, and which sheet of central textile fabric has been impregnated with at least one biological and / or chemical decontamination reagent in an amount sufficient to chemically modify, neutralize and / or decontaminate chemical and / or biological contaminants. A pair of sheets of outer textile fabrics, are positioned on the front and rear sides of the central textile fabric. The sheet of central textile fabric and the pair of sheets of outer textile fabrics are attached together via a sealed hem around their perimeter such that it prevents the at least one biological and / or chemical decontamination reagent from passing through the hem.

A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc form or in a tablet, pill, etc form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.

The invention provides a method for producing recombinant human butyrylcholine esterase on large scale by utilizing a biological platform of the mammary gland of a transgenic animal. The method comprises the following steps: utilizing the biological platform of the mammary gland of the transgenic animal to efficiently produce holonomic and monomeric recombinant human butyrylcholine esterase on large scale for the first time, namely cut-off type enzyme without containing the last 40 amino acid residues of the holonomic butyrylcholine esterase, and a protein fused with monomeric butyrylcholine esterase and albumin. The produced recombinant protein can be used for preventing and treating apnea caused by poisoning of nerve gas, poisoning of organophosphorus pesticide, poisoning of cocaine and succinylcholine, and is used for detecting and removing residues of organophosphorus pesticide on vegetables, melons, fruits, other crops, surfaces of various articles and soil.

A patch device worn by a user is disclosed that is configured to sense the presence of a harmful substance in the environment and to deliver an antidote to that substance into the user without the intervention of the user. The patch device incorporates a sensing mechanism configured to sense a presence of the harmful substance in the environment surrounding the patch device. On sensing the presence of the harmful substance, the sensor triggers a delivery mechanism, which causes the therapeutic agent to be injected into the user. The therapeutic agent acts to antidote the effects of the harmful substance within the user. The patch device could be used for protection against exposure to substances such as nerve gas and pesticides. The patch could be used to deliver the therapeutic agent either subcutaneously or transdermally.

The invention discloses a fluorescent probe for detection of a nerve gas simulacrum, fluorescent test paper and preparation methods of the fluorescent probe and the fluorescent test paper. The fluorescent probe for detection of the nerve gas simulacrum has a structural formula shown in the description, in the formula, R is located on an arbitrary substitution position of a benzene ring, and R is H, OCH3 or Cl. The fluorescent probe provided by the invention has fluorescence specificity on nerve gases such as halogenated phosphates, and can perform fluorescent lighting fluorescence sensing on the nerve gases, so that detection of the nerve gases can be realized, the detection sensitivity is high, and the detection limit is low; and the fluorescent test paper prepared from the fluorescent probe can be used to detect the halogenated phosphate nerve gases in a gas atmosphere, the detection method is simple, and the fluorescent test paper has low preparation costs and is convenient to carry.

The invention discloses monomolecular layer fluorescent sensing thin film-based sensor array and a mode identification thereof on harmful gas. The sensor array comprises microarray monomolecular layerfluorescent sensing thin films, and each sensing thin film is formed by generating absorption of ion liquids of two amphiphilic boron-dipyrromethene derivative or PEG 200 solution at a hydrophilic microregion with a hydrophilic and hydrophobic microregion gold substrate and automatically assembling the two amphiphilic boron-dipyrromethene derivatives at a gas-liquid interface. A fluorescent response signal of each sensing thin film on the harmful gas in a sensor array is acquired, the obtained multi-dimensional fluorescent signal is processed, so that mode identification of the harmful gas such as volatile organic compound, nerve gas and an explosive substance is achieved. The sensor array is low in cost, the microarray monolecular layer fluorescent sensing thin film has the advantages ofgood stability, long service lifetime and high detection sensitivity, the detection method is simple, is easy to operate and is wide in application.

The invention discloses an acridine fluorescent material for detecting a nerve gas analogue, and relates to the technical field of fluorescence sensing. The material consists of triphenylamine and acridine group. The detection performance of molecules is improved by adjusting the number of acridine group, the electron giving ability of the triphenylamine group, and the spatial structure of the optimized molecules. A fluorescent film is prepared by a spin-coating method, and is used for the detection of DCP (Digitally Controlled Potentiometers) gas. The fluorescent film has the advantages of high sensitivity, excellent repeatability, and rapid response to the DCP gas. The detection result shows that the material has potential practical applicability.

The invention discloses a fluorescent compound and a fluorescent probe based on the fluorescent compound as well as a preparation method and an application of visible test paper, and belongs to the technical field of the preparation of the fluorescent compound. Cholesterol (cholic acid) and 8-hydroxyquinoline are respectively used as a side-chain structure and an end-capping structure to be simultaneously introduced into para-position di-benzyne substituted benzene so that a novel fluorescent compound is synthesized and has all supermolecule characteristics. The fluorescent probe prepared by utilizing the fluorescent compound is good in photochemical stability in a water phase and capable of high sensitively and selectively identifying sarin nerve gas and simulants thereof. The preparation method of the fluorescent compound is simple to operate and moderate in reaction condition; the prepared fluorescent probe is good in photochemical stability, high in sensitivity and good in selectivity; when the fluorescent molecular probe is combined with a commodity fluorescent instrument, the environmental sarin poison gas and simulants thereof can be sensitively detected.

The invention relates to the technical field of fluorescence detection and particularly discloses a nitrogen-containing heterocyclic compound, an organic fluorescent film, a preparation method and application. The nitrogen-containing heterocyclic compound belongs to an organic conjugated nitrogen heterocyclic ring molecule, the central nucleus of the molecule has an electron-deficient nitrogen heterocyclic ring structure, and high-sensitivity detection of a nerve poison and / or a nerve poison simulant is realized through lone pair electrons on nitrogen. The preparation method of the nitrogen-containing heterocyclic compound provided by the invention is simple; according to the invention, the nitrogen-containing heterocyclic compound is made into the organic fluorescent film through the electropolymerization method; the method has the advantages of low detection cost, environmental protection, simple operation, high sensitivity, short detection time, repeated use and the like, the problem of low sensitivity of the existing fluorescent material for nerve poison gas detection is solved, and the method has a wide application prospect.

The invention discloses a poly3,4-diethyl hydroxy thiophene gas sensitive material and a preparation method thereof and belongs to the technical field of organic electronic materials. In the invention, a thiophene monomer is introduced to ethyl hydroxyl as an organic phosphorus sensitive functional group by a sample format reaction; and a thiophene organic phosphorus sensitive polymer material of which one branched chain contains the ethyl and hydroxyl is obtained by an oxidative polymerization reaction. Since the hydroxyl is introduced to the thiophene, the polymer sensitive material disclosed by the invention can be used for selectively adsorbing nerve gas and a stimulant thereof so as to enhance the sensitivity and the selectivity of the sensitive material. Meanwhile, according to the poly3,4-ddiethyl hydroxy thiophene gas sensitive material provided by the invention, the ethyl and hydroxyl are introduced to a thiophene repetitive unit, so that the sensitivity is further enhanced. The poly3,4-diethyl hydroxy thiophene gas sensitive material disclosed by the invention can be used for detecting the nerve gas.