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Acridine fluorescent material for detecting nerve gas analogue

A technology of fluorescent materials and analogs, applied in the field of fluorescence sensing, can solve the problems of long detection time, large-scale instruments, limited application, etc., and achieve the effects of low cost of instruments and equipment, easy operation, and simple synthesis method.

Inactive Publication Date: 2019-02-19
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, some technologies have begun to be applied to the trace detection of DCP gas: including surface-enhanced Raman detection technology, fluorescence detection technology, liquid chromatography detection technology, mass spectrometry detection technology, etc., but these technologies generally have high cost, complicated operation, Disadvantages such as long detection time and large-scale instruments limit its application in on-site detection

Method used

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  • Acridine fluorescent material for detecting nerve gas analogue
  • Acridine fluorescent material for detecting nerve gas analogue
  • Acridine fluorescent material for detecting nerve gas analogue

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preparation example Construction

[0031] Preparation of spin-coated thin film: spin-coated thin film has the advantages of simple operation and low cost. The substrate used in the present invention may be a translucent optical material represented by glass sheet, quartz sheet, indium tin oxide (ITO), or filter paper. The solvent used in the present invention can be N,N-dimethylacetamide, N,N-dimethylformamide, acetonitrile, tetrahydrofuran, chloroform, dichloromethane or pyridine, or a mixture of the above solvents.

[0032] The optimized film preparation process is as follows: prepare the TPA-9AC solution at a concentration of 0.5 mg / mL, use tetrahydrofuran as a solvent, rotate at a speed of 1500 r / min, and take 30 seconds for the film to be homogenized. The thickness of the obtained thin film is about 7 nm.

[0033] Application of this kind of thin film in DCP gas detection: the thin film prepared above is placed in different concentrations of DCP gas, and the fluorescence spectrometer records the change of...

Embodiment 1

[0036] Synthesis of compound TPA-9AC:

[0037]

[0038] Synthesis of TPA-9AC:

[0039] 213.66mg 9-chloroacridine, 371.29mg triphenylamine borate was dissolved in 12mL toluene, 8mL salt of wormwood and 6mL ethanol, under the protection of nitrogen, by liquid nitrogen freezing 8min, vacuumize 5min then, add catalyst (four ( Triphenylphosphine) palladium) 166mg, then freeze and vacuum three times to remove oxygen, and reflux at 85°C for 24h. Transfer the solution to a separatory funnel and extract. Using a mixed solvent of dichloromethane and petroleum ether as an eluent, a yellow solid was obtained by column chromatography with a yield of 60%.

[0040] TPA-9AC: 1 H NMR (500MHz, DMSO) δ8.21(d, J=8.7Hz, 2H), 7.84-7.93(m, 2H), 7.77-7.84(d, J=8.6Hz, 2H), 7.64-7.57(m, 2H), 7.56-7.64 (m, 2H), 7.43-7.38 (m, 6H), 7.24-7.18 (m, 6H), 7.17-7.13 (t, J=7.3Hz, 2H). Mass spectrum molecular ion peak: 422.33. Elemental analysis theoretical value: C: 88.12%, H: 5.25%, N: 6.63%. Actual e...

Embodiment 2

[0042] Preparation of spin-coated thin films:

[0043] Prepare a TPA-9AC solution with a concentration of 0.5mg / mL, the solvent is tetrahydrofuran, the speed of the homogenizer is 1500r / min, and the homogenization time is 30s. Finally, the film is vacuum-dried for 10min. The thickness of the film obtained on the substrate is 7nm. ITO (Indium Tin Oxide) glass electrodes are selected. Before use, ITO needs to be ultrasonicated with water, ethanol, acetone, toluene and other solvents for 10 minutes to remove surface impurities.

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Abstract

The invention discloses an acridine fluorescent material for detecting a nerve gas analogue, and relates to the technical field of fluorescence sensing. The material consists of triphenylamine and acridine group. The detection performance of molecules is improved by adjusting the number of acridine group, the electron giving ability of the triphenylamine group, and the spatial structure of the optimized molecules. A fluorescent film is prepared by a spin-coating method, and is used for the detection of DCP (Digitally Controlled Potentiometers) gas. The fluorescent film has the advantages of high sensitivity, excellent repeatability, and rapid response to the DCP gas. The detection result shows that the material has potential practical applicability.

Description

technical field [0001] The invention belongs to the technical field of fluorescent sensing, and in particular relates to an acridine fluorescent material used for detecting nerve gas analogues. Background technique [0002] As a nerve gas, sarin is often used in wars and terrorist attacks. Its deadly toxicity has brought great harm to public safety. Therefore, rapid detection of trace sarin gas has received great attention. Sarin gas cannot be obtained directly due to strict control. Scientists usually use diethyl chlorophosphate (DCP) as a substitute for sarin in scientific research, because DCP has similar chemical activity and low toxicity to sarin. At present, some technologies have begun to be applied to the trace detection of DCP gas: including surface-enhanced Raman detection technology, fluorescence detection technology, liquid chromatography detection technology, mass spectrometry detection technology, etc., but these technologies generally have high cost, complica...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6428G01N2021/6439
Inventor 马洪伟李晓白
Owner NORTHEAST FORESTRY UNIVERSITY
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