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Fluorescent probe for detection of nerve gas simulacrum, fluorescent test paper and preparation methods of fluorescent probe and fluorescent test paper

A technology of fluorescent probes and simulants, applied in the direction of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of low-cost preparation of fluorescent test paper and few small molecule fluorescent materials, and achieve novel structure and detection methods Simple, easy-to-compose effects

Active Publication Date: 2019-08-23
SHENZHEN UNIV
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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a fluorescent probe for the detection of nerve gas simulants, a fluorescent test paper and a preparation method thereof, aiming at solving the problems existing in the detection of halophosphate ester nerve gases. There are still few small molecule fluorescent materials, and the problem that fluorescent test paper cannot be prepared at low cost

Method used

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  • Fluorescent probe for detection of nerve gas simulacrum, fluorescent test paper and preparation methods of fluorescent probe and fluorescent test paper
  • Fluorescent probe for detection of nerve gas simulacrum, fluorescent test paper and preparation methods of fluorescent probe and fluorescent test paper
  • Fluorescent probe for detection of nerve gas simulacrum, fluorescent test paper and preparation methods of fluorescent probe and fluorescent test paper

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Embodiment 1

[0044] (1) 2-Hydroxyacetophenone (40mmol) and terephthalaldehyde diacetal (160mmol) were dissolved in ethanol, then KOH (400mmol) was added, heated to reflux for 24h, cooled to room temperature; after adding hydrogen peroxide (20mL) Continue the reaction for 24 hours, add hydrochloric acid to pH = 1, stir for 5 minutes, remove the solvent under reduced pressure, and obtain the fluorescent probe intermediate through column chromatography (the eluent is a mixed solvent of n-hexane and ethyl acetate with a volume ratio of 7:1). Body 4-(3-hydroxyl-4-oxo-4H-chromene-2-yl) benzaldehyde (being called for short HOFA), productive rate is 45%, and the structural formula of this fluorescent probe intermediate is 1 H-NMR (600MHz, DMSO-d6), δ: 10.09 (br s, 2H), 8.44 (d, J = 8.2Hz, 2H), 8.13 (d, J = 7.9Hz, 1H), 8.09 (d, J =8.2Hz, 2H), 7.84(t, J=7.7Hz, 1H), 7.80(d, J=8.3Hz, 1H), 7.49(t, J=7.4Hz, 1H). 13 C-NMR (150MHz, DMSO-d6), δ: 192.77, 173.27, 154.71, 143.54, 140.41, 136.25, 134.16, 12...

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Abstract

The invention discloses a fluorescent probe for detection of a nerve gas simulacrum, fluorescent test paper and preparation methods of the fluorescent probe and the fluorescent test paper. The fluorescent probe for detection of the nerve gas simulacrum has a structural formula shown in the description, in the formula, R is located on an arbitrary substitution position of a benzene ring, and R is H, OCH3 or Cl. The fluorescent probe provided by the invention has fluorescence specificity on nerve gases such as halogenated phosphates, and can perform fluorescent lighting fluorescence sensing on the nerve gases, so that detection of the nerve gases can be realized, the detection sensitivity is high, and the detection limit is low; and the fluorescent test paper prepared from the fluorescent probe can be used to detect the halogenated phosphate nerve gases in a gas atmosphere, the detection method is simple, and the fluorescent test paper has low preparation costs and is convenient to carry.

Description

technical field [0001] The invention relates to the field of small molecule fluorescent probes, in particular to a fluorescent probe for detecting nerve gas simulants, a fluorescent test paper and a preparation method thereof. Background technique [0002] Sarin (GB) and soman (GD) are two representative nerve gases, both of which are halophosphates; these compounds can irreversibly react with acetylcholinesterase in the human central nervous system, Thereby destroying nerve impulses, which can cause suffocation, cardiac arrest and other symptoms within a few minutes and lead to death; and such compounds have been widely used in chemical weapons and pesticides since World War I. Therefore, it is of great significance to develop a rapid and accurate sensing method for the detection of halophosphate nerve gases. [0003] As a detection method with short response time, high sensitivity, high temporal and spatial resolution, and visualization, fluorescence sensing has been wide...

Claims

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Application Information

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IPC IPC(8): C07D311/30C09K11/06G01N21/64
CPCC07D311/30C09K11/06C09K2211/1007C09K2211/1088G01N21/643G01N2021/6439
Inventor 刘斌秦天依
Owner SHENZHEN UNIV
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