40 results about "Microbial colonization" patented technology

A catheter device has an elongate body and a chamber positioned within the elongate body. The chamber has a chamber opening, and a barrier, such as a gate, moves over the chamber opening. The barrier moves between an uncovered position uncovering the chamber opening and a covered position covering the chamber opening. The catheter has at least one cutting edge by the chamber opening. In particular, the at least one cutting edge may be on the barrier, where the at least one cutting edge is guided over the chamber opening with movement of the barrier between the uncovered position and the covered position. The cutting edge cuts away a fibrin sheath blocking the chamber opening. The catheter may have multiple chambers connected by channels that allow the chambers to be flushed to prevent microbial colonization.

A catheter device has an elongate body and a chamber positioned within the elongate body. The chamber has a chamber opening, and a barrier, such as a gate, moves over the chamber opening. The barrier moves between an uncovered position uncovering the chamber opening and a covered position covering the chamber opening. The catheter has at least one cutting edge by the chamber opening. In particular, the at least one cutting edge may be on the barrier, where the at least one cutting edge is guided over the chamber opening with movement of the barrier between the uncovered position and the covered position. The cutting edge cuts away a fibrin sheath blocking the chamber opening. The catheter may have multiple chambers connected by channels that allow the chambers to be flushed to prevent microbial colonization.

This invention relates to the field of gas-containing storage vessels, and more specifically to the provision for antimicrobial surfaces within such vessels and in the connecting hardware associated with various applications of such vessels, so that microbial colonization of the interior of such vessels may be eliminated or retarded. This antimicrobial feature may result in improved safety in the use of such vessels, with reduced risk of the transmission of infection to a user. The invention further includes methods to provide gas-containing storage vessels with antimicrobial surfaces, so that microbial colonization of the interior of such vessels may be eliminated or retarded.

The present invention relates to the use of the cyclic dinucleotide c-di-GMP and cyclic dinucleotide analogues thereof in a method for attenuating virulence of a microbial pathogen or for inhibiting or reducing colonization by a microbial pathogen. This method further inhibits microbial biofilm formation and is capable of treating bacterial infections. The microbial colonization or biofilm formation inhibited or reduced may be on the skin or on nasal or mucosal surface. The microbial colonization or biofilm formation inhibited can also be on the surfaces of medical devices, especially those in close contact with the patient, as well on the surfaces of industrial and construction material where microbial colonization and biofilm formation is of concern.

A wound dressing device for use with a transcutaneous medical device such as a cannula or a catheter comprises a polyurethane matrix which may be covered with a film backing. Chlorhexidine di- gluconate and a polyanhydroglucuronic salt are contained in the polymer matrix. The wound dressing device prevents microbial colonization of the dressing and stops bleeding from the insertion site. The device provides combined haemostatic and antimicrobial effects at the insertion site but without adversely affecting wound healing.

Various methods can be employed to apply an antimicrobial coating to the outer surface of catheter tubing. The antimicrobial coating minimizes the risk of microbe colonization on the outer surface of the catheter tubing when the catheter tubing is positioned within the vasculature of a patient. A catheter can be manufactured using a pre-treatment process which applies the antimicrobial coating to the catheter tubing prior to applying a lubricant over top of the coating. The lubricant can function to retain the coating on the outer surface and also to limit the diffusion of the antimicrobial agent from the coating. A catheter can include an antimicrobial coating that does not block the visibility of flashback. Because the antimicrobial coating can be minimally transparent, the coating can be applied to the outer surface in a striped pattern or other pattern that leaves a portion of the outer surface uncoated or minimally coated. The flashback will then remain visible through the portions of the catheter tubing where no coating or minimal coating is present.

An isolated strain of Enterococcus faecalis GALT deposited under number C E C T 7121 of the group of lactic bacteria is disclosed, which is capable of surviving and colonizing the gastrointestinal tract of humans and / or animals and showing beneficial probiotic activity for the health of humans and animals. The strain E. faecalis GALT and / or a culture supernatant and / or metabolites thereof shows no in vitro multiresistance to antibiotics of common use in human clinics as glycopeptides, such as vancomycin, teicoplanine; carbapenemes, such as impipenem, meropenem; and ampicillin. The strain E. faecalis GALT contains no red blood cell-destroying hemolysins of human, ovine and equine origin; and it does not produce any gelatinase, DNase and decarboxylases. The strain E. faecalis GALT is useful for the preparation of a composition intended for the treatment and / or prophylaxis of disorders associated with colonization by pathogenic microorganisms of the gastrointestinal tract; for use as a regulator of the immune response in human and animals, as well as for the preparation of a composition. The invention is also directed to methods and uses of the strain E. faecalis GALT.

Antiseptic compounds that act as persistent and fast acting antiseptics and disinfectants. The base of these antiseptic actions is CaF2 as the persistent part, preventing the colonization of tissue and nonliving surfaces with microorganisms through the targeted on-demand release of fluorine ions. For fighting heavy contamination and invasion of transient microbes through new application of the solution, fast acting alcohols and toxic solutions have been added in small percentage. They act fast and evaporate fast, leaving the natural protection of skin undamaged and coated with a persistent antiseptic.

The invention belongs to the field of high value conversion and utilization of biological waste, in particular to a soil improving hydrogel, a preparation method thereof and application thereof. The hemicellulose-containing wastewater is used as a solvent, mixed with a hydrogel monomer and a crosslinking agent, and a crosslinked polymer obtained by polymerization is a hydrogel. The water-retainingagent provided by the invention can directly use the hemicellulose-containing wastewater as the solvent, thereby eliminating the high energy consumption and chemical reagent costs of separation and purification of hemicellulose; oligosaccharide rich therein and phosphorus and potassium and other elements added during the preparation process can be used as a supplementary nutrient for crops and soil microorganisms to promote the water retention performance of a soil ecological improving agent and microbial colonization. The other components in by-products are utilized, and no wastewater is discharged during the entire utilization process, thereby providing an economical and environment-friendly route for hemicellulose treatment in the pulping and viscose fiber industries.

The invention relates to the technical field of microbial colonization and concretely relates to a method for colonizing Beauveria bassiana in a corn seedling stage and a use thereof. The method comprises disinfecting surfaces of corn seeds, and soaking the seeds in a Beauveria bassiana spore suspension, wherein the Beauveria bassiana strain is preserved in the China general microbiological culture collection center on January 23, 2013 and has an accession number of CGMCC7192. The method is simple and easy and ensures the optimal seed soaking time and colonization preference of Beauveria bassiana in a corn seedling stage. Through colonization of entomogenous fungi in a plant, plant resistance is improved so that pathogen-caused damage to plants is reduced and plant pests are avoided through indirect regulation and control of phytophagous insects.

The present invention provides an antibacterial facial mask with whitening and moisturizing effects. The technical scheme is boldly improved on the basis of the conventional facial mask formula, and the dosage of each component is optimized on the basis of screening and combination of common ingredients in cosmetics. The proportion of lipid components has been increased and sodium hyaluronate has been added to help improve the moisturizing effect of the product. On this basis, aiming at the problem that the ingredients of the facial mask are deposited in the skin as organic matter and cause microbial colonization, the present invention adds natural antibacterial ingredients such as white peony root, honeysuckle, and desmodium to the facial mask, which has outstanding antibacterial effect and is mild and non-toxic to the skin. At the same time, in order to promote the contact area between the mask components and the skin, especially to promote the penetration of antibacterial ingredients into the pores, the present invention adds surfactant disodium lauryl sulfosuccinate, which helps reduce the mask Surface tension enhances the antibacterial effect.

The invention discloses a fattening pig feed and a preparation method thereof. According to the fattening pig feed disclosed by the invention, a concentrated feed is mixed with a green feed and a traditional Chinese medicine additive, so that secretion of digestive tracts can be facilitated, the appetite of animals can be promoted, the digestion functions can be improved, the field planting of beneficial microorganisms can be promoted, balance of intestinal flora can be maintained, invasion of pathogenic bacteria is stopped, the fattening pig feed is good in palatability, the active components of the feed can be effectively preserved, the immune functions of pigs can be strengthened, the waste of the feed is also reduced, the usage quantity of the concentrated feed is reduced, and the cost is reduced. After the pigs are fed with the fattening pig feed, the growth vigor of the pigs is good, the hair color of the pigs is bright, the pigs can become full-grown and ready for slaughter about a week ahead of time, the quality and the flavor of pork are improved, the pork meets requirements of people for green pork, and the pork has great competitiveness in the market.

The invention relates to a preparation method and application of a graphene composite material, in particular to a preparation method and application of a graphene / polypyrrole composite material withthree-dimensional multi-stage pores. The invention aims at solving the technical problems that the existing bioelectrochemical system is low in biomass concentration, poor in electron transfer and weak in microbial affinity. The preparation method comprises the steps of firstly, preparing a graphene oxide colloidal suspension liquid; secondly, carrying out cyclic voltammetry deposition. The graphene / polypyrrole composite material with the three-dimensional multi-stage pores is applied to a bioelectrochemical system as a biological electrode. The graphene / polypyrrole composite material, prepared by the method, with the three-dimensional multi-stage pores is provided with an open porous three-dimensional interconnected conductive support, and is higher in surface roughness, thus being beneficial to microbial colonization and transfer of extracellular electron to the electrode. The graphene / polypyrrole composite material with the three-dimensional multi-stage pores has a sandwich structure in which a graphene layer is protected by a polypyrrole layer, so that the colonization of microorganisms is facilitated.

Provided is an antimicrobial substrate comprising a substrate to which is covalently bonded an antimicrobial polymer, in which the antimicrobial polymer comprises an alkylene oxide backbone to which are attached one or more alkyl and / or alkylene oxide primary and / or secondary branches, at least one of the alkyl or alkylene oxide primary and / or secondary branches is functionalized with a quaternary ammonium or a fluorinated group, or at least two of the alkyl and / or alkylene oxide primary and / or secondary branches are functionalized with a quaternary ammonium and a fluorinated group. The antimicrobial substrate can be used, for example, in a method for protecting an object against microbial infection, microbial colonization, or microbial transinfection comprising providing to the object an antimicrobial substrate.

The invention provides a forest drought-resistant growth-promoting colloidal matrix and application thereof. The matrix is formed by well mixing a solid bacterial agent, turf, perlite and vermiculite,the solid bacterial agent is formed by uniformly inoculating drought-resistant microbial combined bacteria liquid into a colloidal fermentation material, and the drought-resistant microbial combinedbacteria liquid is formed by compounding bacillus subtilis GE3, bacillus cereus Z77 and lactobacillus casei 1.0580. Drought-resistant growth-promoting activity of bacillus subtilis GE3 can be given into full play, and coordinated symbiosis effect of bacillus subtilis GE3 among strains can be brought into play; a water-washing cow dung and cow dung biogas residue mixed fermentation product is addedinto the matrix, so that microbial colonization survival performance is further improved, reutilization of waste resources like cow dung is realized, and the matrix has great value in actual application.

A feed of pig for increasing growth speed and carcass quality is prepared from corn, bean dregs, wheat bran, fish powder, stone powder, whey powder, calcium hydrogen phosphate, edible salt, cactus powder and premixed material thruogh respective pulverizing and proportional mixing.

The invention discloses a modifier for a microbial adhesion rate and application thereof, and relates to the technical field of biology. The modifier for the microbial adhesion rate is suitable for regulating the adhesion rate of microorganisms with the mucous membranes or the skin, and contains a surfactant, and the concentration of the surfactant is lower than the critical micelle concentration (CMC) of the surfactant. The modifier for the microbial adhesion rate can increase the probability and speed of the contact of the microorganisms and the mucosal cells or skin cells. Meanwhile, by the adoption of the surfactant, the cell-surface hydrophobicity of the microorganisms is changed, the microbial adhesion rate of the beneficial microorganisms with the mucosal epithelial cells or the skin cuticle is increased, the microorganisms are easily colonized on the mucous membranes or the skin, the microorganisms can continuously take effect for a long time, the modifier has broad application prospects.

The invention discloses a preparation method of a gel dressing containing silk fibroin. The gel dressing is prepared from the following components in parts by weight: 2-10 parts of silk fibroin, 3-6 parts of earthworm protein, 2-4 parts of phycocyanin, 6-10 parts of N-acetyl-D-glucosamine, 1-4 parts of carbomer, 3-6 parts of hydroxyethyl cellulose, 3-7 parts of fatty acid, 2-5 parts of gelatin, 1-3 parts of sodium chloride, 2-5 parts of propylene glycol, 2-6 parts of hyaluronic acid, 1-6 parts of sodium benzoate, 2-8 parts of Tween-80, 1-3 parts of radix arnebiae seu lithospermi, 4-6 parts of herba menthae and 20-40 parts of purified water. By matching the silk fibroin with the earthworm protein, the phycocyanin, the N-acetyl-D-glucosamine, the carbomer and the hydroxyethyl cellulose, the effects of nutrient repair, tissue regeneration and biocompatibility can be fully exerted, so that the product provides a good microenvironment on the premise of inhibiting germs and promoting tissue repair and regeneration, a protective film is formed, pathogenic microorganisms are prevented from colonization, and the effects of nutrient repair of skin tissues, promotion of tissue growth, protection of wound surface microenvironment, environment cleaning, water locking, moisturizing and the like are achieved.

The present invention pertains to a homogeneous microorganism extract using useful and functional microorganisms and a method for producing the same, and particularly to: a homogeneous microorganism extract which is obtained by homogenizing and extracting a complex enzyme, various inducing substances and the like by using useful microorganisms and functional microorganisms that are isolated from soil for the purpose of soil improvement, crop growth and pest control; and a method for producing said homogeneous microorganism extract. The method is technically characterized by the following: the homogeneous microorganism extract using useful and functional microorganisms and the method for producing the same are characterized in that: microorganisms are homogenized with a complex enzyme (protein, sugars, fat, fiber, synthetic enzymes for acids and alkalis, and decomposition enzymes etc.), primary metabolites, secondary metabolites, antibiotic substances, various active materials, and the like, which are produced through combination culture in which cultured useful microorganisms and functional microorganisms are made and cultured under a symbiotic relationship such that the useful microorganisms and functional microorganisms serve as a substrate and a raw material; then microorganism inducing substances, crop growth inducing substances, and pest resistance inducing substances are extracted from microorganism cells; and the resultant extract is sterilized and concentrated. Therefore, since said extract includes the complex enzyme, various inducing substances, and the like, the functions of soil improvement, crop growth and pest control are achieved. Accordingly, the present invention is advantageous in cost saving and income increase; advantageous in that the types and number of useful microorganisms can be increased by inducing sunflower bacteria that has been already settled, instead of settling the microorganisms on soil and crops as in conventional microorganism formulations; and advantageous in that the extract directly affects crops so that desired effects are relatively quickly expressed and microbial flora is improved.

The invention discloses a biological loading module which is used as a biomass carrier required in an anaerobic bioreactor. The anaerobic bioreactor is used for treating organic wastes from animals and plants so as to produce organic fertilizers and biogas. The module comprises a model for microbial colonization formed by vertically oriented tubular elements fixed along a longitudinal surface; themodule has a layered structure; the module elements located in adjacent layers leave gaps between the layers; the module elements are made of a polymer material, have a porous structure, and can ensure the penetration of microorganisms. The present invention can accelerate the process of treating biomass by improving the degree of mixing of biomass and increasing the number of microorganisms in the module volume.

The invention relates to an application of a graphene / polypyrrole composite material with three-dimensional multilevel holes, which relates to an application of a graphene composite material. The invention aims to solve the technical problems of low biomass concentration, poor electron transfer and weak microbial affinity in the current bioelectrochemical system. The present invention: 1. preparation of graphene oxide colloidal suspension; 2. cyclic voltammetry deposition. The three-dimensional multi-level porous graphene / polypyrrole composite material of the present invention is used as a bioelectrode in a bioelectrochemical system. The graphene / polypyrrole composite material with three-dimensional multi-level holes prepared by the invention has an open porous three-dimensional interconnected conductive scaffold and has a relatively high surface roughness, which is beneficial to the colonization of microorganisms and the transfer of extracellular electrons to electrodes. The graphene / polypyrrole composite material with three-dimensional multi-level holes of the present invention has a sandwich structure, wherein the graphene layer is protected by the polypyrrole layer, which facilitates colonization of microorganisms.

The invention discloses an in vitro intestinal model based on primary intestinal cells and its construction method and application. The electrospun nanofiber membrane is used as the carrier material of intestinal cells, and isolated intestinal cells are seeded on the surface of the carrier material. , cultivated until a complete intestinal cell layer is formed and the small intestinal villi are differentiated, and an in vitro intestinal model with complete biological activity and physiological functions is obtained. Based on the three-dimensional structure similar to the natural extracellular matrix of the electrospun nanofiber membrane, the present invention realizes the biomimetic simulation of the natural extracellular matrix structure, and greatly improves the adhesion and growth performance of the primary intestinal cells on the surface of the carrier material. The constructed model has the ability to imitate the real intestinal tract, and can be widely used in the absorption and transport analysis of nutrients and drug components, quickly and accurately evaluate the absorption capacity and bioavailability of nutrients and drugs, and can also be used to evaluate intestinal Microbial colonization or interaction with tracts can be used for tissue engineering.

Described are methods for disinfecting a physical or biological surface by contact with an antimicrobial formulation comprising a substituted tolan compound, the substitutions being, for example, one or more alkoxy, (e.g., methoxy) and hydroxy substituents at one or both phenyl rings of the tolan. The compounds and methods are -static and / or -cidal, depending on dose and suspected microbe. Suspected pathogenic microbes include Gram negative bacteria, such as P. aeruginosa and E. coli, Gram positive bacteria, such as S. aureus, including MRSA, and fungal pathogens, such as Candida genus and C. albicans. Also described are methods for inhibiting or disrupting biofilm formation of a microbe or microbes.

The invention provides a forest drought-resistant growth-promoting colloidal matrix and application thereof. The matrix is formed by well mixing a solid bacterial agent, turf, perlite and vermiculite,the solid bacterial agent is formed by uniformly inoculating drought-resistant microbial combined bacteria liquid into a colloidal fermentation material, and the drought-resistant microbial combinedbacteria liquid is formed by compounding bacillus subtilis GE3, bacillus cereus Z77 and lactobacillus casei 1.0580. Drought-resistant growth-promoting activity of bacillus subtilis GE3 can be given into full play, and coordinated symbiosis effect of bacillus subtilis GE3 among strains can be brought into play; a water-washing cow dung and cow dung biogas residue mixed fermentation product is addedinto the matrix, so that microbial colonization survival performance is further improved, reutilization of waste resources like cow dung is realized, and the matrix has great value in actual application.

The invention discloses a preparation method of a polyglutamic acid colloidal solution and dressing. The preparation method comprises the steps that polyglutamic acid is matched with recombinant human collagen, N,O-carboxyethyl chitosan, xanthan gum and sodium hyaluronate, so that the effects of wound protection, repair and tissue regeneration can be fully exerted; then natural bactericidal and anti-inflammatory substances in plants such as rosemary, green tea, a crinite extract, bay leaves and a sandalwood extract liquid are used for replacing traditional preservatives or antibiotic drugs such as aspirin and isobutylphenylpropionic acid, so that side effects on a human body are reduced; and drug resistance of skin or mucous membranes cannot be generated for a long time, glycerin and hyaluronic acid are adopted to form a layer of wet film in skin or mucous membrane, so that the product provides a good microenvironment on the premise of inhibiting germs and promoting tissue repair and regeneration, a protective film is formed, pathogenic microorganisms are prevented from colonization, and finally, the functions of restoring skin tissues, promoting tissue growth, protecting a wound microenvironment, cleaning the environment and locking water and preserving moisture are achieved.