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167results about How to "Increase infection" patented technology

Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

InactiveUS6939543B2Enhance phagocytosis and killing of the bacteriaIncrease infectionAntibacterial agentsHybrid immunoglobulinsBacteroidesBinding site
The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and / or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.
Owner:THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC +1

Fc receptor modulating compounds and compositions

The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Owner:THE MACFARLANE BURNET INST FOR MEDICAL RES & PUBLIC HEALTH LTD

Antifungal composition, method and kit for topically treating onychomycosis

An activator comprising a biocompatible base and a known fungicide in the form of an acid salt are mixed together by the user shortly before being applied to the infection so as to react them chemically to produce the free base of the fungicide thereby rendering the composition capable of penetrating throughout the infected tissue. The free base form has been found to be much more lethal to the fungal infection, particularly in the treatment of onychomycosis. The activator is formulated to be mixed within a few days of or just before application with the fungicide, e.g., terbinafine hydrochloride (an acid salt). Although the free base is subject to degradation and has a shorter shelf life, it was found that mixing just prior to use eliminates problems that could be caused by degradation of an active ingredient. A preferred activator solution also contains a penetration enhancer and a tissue softener.
Owner:ROLF DAVID

Dressing device for use wtih a cannula or a catheter

A wound dressing device for use with a transcutaneous medical device such as a cannula or a catheter comprises a polyurethane matrix which may be covered with a film backing. Chlorhexidine di- gluconate and a polyanhydroglucuronic salt are contained in the polymer matrix. The wound dressing device prevents microbial colonization of the dressing and stops bleeding from the insertion site. The device provides combined haemostatic and antimicrobial effects at the insertion site but without adversely affecting wound healing.
Owner:BARD ACCESS SYST

Method for controlling tobacco bacterial wilt

The invention discloses a method for controlling tobacco bacterial wilt. The tobacco bacterial wilt is controlled by soil improvement, balance of soil nutrient and a tobacco seedling treatment system. The method specifically comprises the following steps of: adding a modifier to a tobacco planting field, then carrying out soil ploughing before winter; fertilizing a base fertilizer to the improved soil; fertilizing the base fertilizer to a hole before transplanting the tobacco seedling; carrying out root dipping treatment by bacteria liquid of paenibacillus polymyxa or bacillus cereus before transplanting the tobacco seedling; carrying out spray treatment by chitosan or brassinolide at the resettling stage; and carrying out root irrigation treatment for 2-3 times by mixed solution of ethylicin or mancozeb at the vigorous growing stage, wherein the interval is 7 days each time. By utilizing the method disclosed by the invention, explosion of the tobacco bacterial wilt can be delayed; the tobacco yield can be increased; the tobacco quality is improved; meanwhile, the acid soil can be improved; and the method can be widely applied to the tobacco planting industry.
Owner:TOBACCO SCI RES INST CHONGQING CITY COMPANY OF CHINA NAT TOBACCO +1

A biological weed killer and preparation process thereof

The invention relates to a method for preparing biological weed killer, wherein it uses Curvularia Boedijn Mds0404 CGMCC NO. 1827 as seed, which comprises 80-95% spore, 0-18% chemical weed killer, and 2-5% agent. And its production comprises that: activating seed, cultivating seed liquid, cultivating spore and collecting components. The invention has low cost and wide application.
Owner:ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES

Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

InactiveUS20080019976A1Enhance phagocytosis and killing of the bacteriaHigh degree of sequence homologyAntibacterial agentsPeptide/protein ingredientsHuman sequenceLipoteichoic acid binding
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
Owner:BIOSYNEXUS INC

Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells

InactiveUS7332337B2Reduce infectionReduced and increased CTL responseBiocideVectorsMast cellViral nucleic acid
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a viral particle containing a modified viral coat proteins containing adenoviral amino acid sequence from an adenoviral serotype Ad35 or Ad51 fiber protein, arrays of subpopulations of cells made by such methods, and a method for a ex vivo transduction of a population of cells.
Owner:GALAPAGOS GENOMICS

Unauthorized access program monitoring method, unauthorized access program detecting apparatus, and unauthorized access program control apparatus

The apparatus analyzes management information about network information collected from a computer and a router, detects a change in the management information specific to the activity of an unauthorized access program (worm), and generates alert information including a type of apparatus whose collected management information indicates the detected change and address information about an apparatus suspected of performing the activity of a worm. When the type of apparatus in the alert information refers to a computer, the apparatus generates an instruction to delete relayed information for the computer. When the type of apparatus refers to a network connection apparatus, the apparatus generates an instruction to set a filter for cutting off the communications of a worm with the network connection apparatus. Thus, the apparatus transmits the instructions.
Owner:FUJITSU LTD

Imidazopyridine compounds, as well as preparation method and application thereof

The invention discloses 2,7-substituted 3H-imidazole[4,5-b]pyridine compounds shown as the structural formula I, or pharmaceutically acceptable salt, ester and precursors, and / or hydrate and medicinal compositions thereof, and a preparation method for the compounds. The compounds, or pharmaceutically acceptable salt, ester and precursors, and / or hydrate and medicinal compositions thereof can serve as antagonists of CR4 and are used for treating or preventing CXCR4 receptor activation related diseases.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Nucleic acid encoding fusion polypeptides that prevent or inhibit HIV infection

The present invention is directed to an isolated nucleic acid molecule encoding a fusion polypeptide the expression of which in cells is capable of blocking the entry of HIV-1 into host cells and methods of using the nucleic acid molecule.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Methods and kits for for locking and and disinfecting implanted catheters

InactiveUS20020082582A1Reduce riskInhibiting fouling and plugging of the lumenInfusion devicesMedical devicesCvd riskThrombus
Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol. The use of an alcohol can both reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as reducing the risk of infection. The risk of infection can be further reduced by employing a catheter body which is sufficiently porous to permit the lower alcohol or other anti-microbial solution to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
Owner:EXCELSIOR MEDICAL

Special clinical nutritional formula for gynecological inflammation and preparation method thereof

The invention provides a special clinical nutritional formula for gynecological inflammation. The special clinical nutritional formula comprises the following components in parts by weight: 14-30 parts of protein, 1-10 parts of fat, 45-65 parts of carbohydrates, 5-10 parts of dietary fibers, 0.5-1.5 parts of major elements, 0.008-0.05 part of trace elements, 0.008-0.02 part of fat-soluble vitamins, 0.09-0.28 part of water-soluble vitamins, 0.05-2 parts of dietary essence, 0.5-3 parts of medicinal and edible components and 0.005-2 parts of new resource food. The invention also provides a preparation method of the nutritional formula. The special clinical nutritional formula is capable of improving the body functions of patients, strengthening nutrients, improving body immunity to avoid repeated attack of gynecological inflammation and simultaneously relieving the symptoms of gynecological inflammation.
Owner:上海奥医生物医药科技有限公司

Composition for improving plant health and method of applying same

InactiveUS20130210624A1Increase protectionIncrease metabolic responseBiocideInorganic phosphorous active ingredientsFertilizerIon
A granular material employed as a fungicide or a fertilizer or both, comprising phosphorous acid (H3PO3) or phosphite (which may include HPO3), along with a metal and phosphate on a granular carrier; or a mixture of a phosphite product and a phosphate product on a granular carrier; or mixture of a metal phosphite product and phosphate on a granular carrier. The mixture may contain a chelated metal on a granular carrier. Another mixture includes a phosphite product on a first granular carrier, and a phosphate product on a second granular carrier wherein the two are mixed and the phosphite product and the phosphate product may or may not include a metal ion. Alternatively the mixture may also contain a chelated metal on a third granular carrier. The compositions herein are preferably equipped with a time release mechanism.
Owner:QUEST PROD

Tumourolytic anticancer recombined adenovirus with tumour target direction and idioctonia

The invention offers two sets of tumor-dissolving recombination adenovirus. One set is produced by rite-directed mutagenesis in virus E1A gene. The other set produced by replacing E1A promoter with tumor specificity promoter. The fiber end of parts of the recombination adenovirus is added RGD short peptide. And parts of are carried HSV1-tkm. It is proved by experiment that the two sets of virus can strongly infect tumor cell, do a great deal replication and breeding, and finally dissolve cell. The released filial generation adenovirus can infect around tumor cell again. Thus dosage effect and against cancer capability of virus gene can be enlarged by breeding infecting cycle. The tow sets of tumor-dissolving recombination adenovirus appearances strong against cancer effect in animal subcutaneous, human liver and lung tumor model test.
Owner:陈智博

Unauthorized access program monitoring method, unauthorized access program detecting apparatus, and unauthorized access program control apparatus

The apparatus analyzes management information about network information collected from a computer and a router, detects a change in the management information specific to the activity of an unauthorized access program (worm), and generates alert information including a type of apparatus whose collected management information indicates the detected change and address information about an apparatus suspected of performing the activity of a worm. When the type of apparatus in the alert information refers to a computer, the apparatus generates an instruction to delete relayed information for the computer. When the type of apparatus refers to a network connection apparatus, the apparatus generates an instruction to set a filter for cutting off the communications of a worm with the network connection apparatus. Thus, the apparatus transmits the instructions.
Owner:FUJITSU LTD

Method for extracting cordycepin

The invention relates to a method for extracting cordycepin. The method includes the following steps of subjecting a cordycepin fermentation liquid to reduced pressure concentration, then performing ultrasonic extraction in combinations of microwaves and light waves respectively, and further subjecting an obtained extraction liquid to separation and purification to obtain the cordycepin. Compared with traditional extraction methods, the method has the advantages that by means of the method, the extraction ratio is improved, extraction time is saved, and purity is increased.
Owner:SHIJIAZHUANG ZANGNUO BIOTECH

Treatment of AMD using aav2 variant with aflibercept

The present disclosure provides pharmaceutical compositions and methods thereof for the treatment of age-related macular degeneration (AMD) in a subject by administering intravitreally a pharmaceutical composition adapted for gene therapy, comprising a vector having a nucleic acid sequence that encodes aflibercept.
Owner:ADVERUM BIOTECH INC

Single particle nano-garlicin micro-capsule, and its prepn. method

A garlicin nanoparticle microcapsule contains the active components (garlicin, allicin, Se, Ge, etc) and the wall material (modified starch N-LOK or beta-CD). Its preparing process includes washing garlic cloves, proportionally mixing it with alcohol, dichloromethane, or water multi-dimension microwave extracting, filtering, vacuum concentrating, condensing, adding said modified starch N-LOK or beta-CD, low-temp stirring, and spray drying.
Owner:INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES +1

Application of streptococcus pneumoniae protein to resisting infection of S. pneumoniae

The invention provides application of S. pneumoniae protein to resisting infection of S. pneumoniae. The endopeptidase O (PepO) of S. pneumoniae is a subcutaneous immunologic adjuvant, and the prepared S. pneumoniae protein vaccines have the good protection effects on resisting infection of S. pneumoniae through mixing and fusing expression of the subcutaneous immunologic adjuvant and 673rd to 863rd amino acid peptide fragment of zinc metal protease B (ZmpB).
Owner:CHONGQING MEDICAL UNIVERSITY
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