164results about How to "Increase infection" patented technology

The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and / or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.

The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and the resulting chimeric antibody provides a previously unknown means to diagnose, prevent and / or treat infections caused by gram positive bacteria bearing lipoteichoic acid. This invention also encompasses a peptide mimic of the lipoteichoic acid epitope binding site defined by the monoclonal antibody. This epitope or epitope peptide mimic identifies other antibodies that may bind to the lipoteichoic acid epitope. Moreover, the epitope or epitope peptide mimic provides a valuable substrate for the generation of vaccines or other therapeutics.

The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

The invention discloses a method for controlling tobacco bacterial wilt. The tobacco bacterial wilt is controlled by soil improvement, balance of soil nutrient and a tobacco seedling treatment system. The method specifically comprises the following steps of: adding a modifier to a tobacco planting field, then carrying out soil ploughing before winter; fertilizing a base fertilizer to the improved soil; fertilizing the base fertilizer to a hole before transplanting the tobacco seedling; carrying out root dipping treatment by bacteria liquid of paenibacillus polymyxa or bacillus cereus before transplanting the tobacco seedling; carrying out spray treatment by chitosan or brassinolide at the resettling stage; and carrying out root irrigation treatment for 2-3 times by mixed solution of ethylicin or mancozeb at the vigorous growing stage, wherein the interval is 7 days each time. By utilizing the method disclosed by the invention, explosion of the tobacco bacterial wilt can be delayed; the tobacco yield can be increased; the tobacco quality is improved; meanwhile, the acid soil can be improved; and the method can be widely applied to the tobacco planting industry.

The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.

The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including the immunogens.

The apparatus analyzes management information about network information collected from a computer and a router, detects a change in the management information specific to the activity of an unauthorized access program (worm), and generates alert information including a type of apparatus whose collected management information indicates the detected change and address information about an apparatus suspected of performing the activity of a worm. When the type of apparatus in the alert information refers to a computer, the apparatus generates an instruction to delete relayed information for the computer. When the type of apparatus refers to a network connection apparatus, the apparatus generates an instruction to set a filter for cutting off the communications of a worm with the network connection apparatus. Thus, the apparatus transmits the instructions.

Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and / or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.

The invention relates to a method for extracting cordycepin. The method includes the following steps of subjecting a cordycepin fermentation liquid to reduced pressure concentration, then performing ultrasonic extraction in combinations of microwaves and light waves respectively, and further subjecting an obtained extraction liquid to separation and purification to obtain the cordycepin. Compared with traditional extraction methods, the method has the advantages that by means of the method, the extraction ratio is improved, extraction time is saved, and purity is increased.

The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including the immunogens.