435 results about "Inductively coupled plasma mass spectrometry" patented technology

The invention provides a method for detecting trace elements in human body whole blood through an inductively coupled plasma mass spectrometry method and belongs to the technical field of biotechnical detection. The method comprises the following steps: (1) pre-treating a whole blood sample; (2) detecting a mixed element standard solution and a to-be-detected sample solution by an inductively coupled plasma mass spectrometer; and (3) performing quantitative analysis on a detection result and calculating the content of to-be-detected elements in the human body whole blood sample. The method provided by the invention can be used for simultaneously detecting the content of trace elements, such as magnesium, manganese, calcium, iron, copper, zinc and lead, in the human body whole blood; the sample dosage is less; the pretreatment is simple; the cost is low; the whole detection process is short in time and high in efficiency; the detection sensitivity and precision andthe detection stability are high.

A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.

The invention belongs to the technical field of food safety detection, and particularly provides a method for determining traces of mercury, cadmium, lead and arsenic in a food by a microwave digestion-inductively coupled plasma mass spectrometry (ICP-MS).

The invention discloses a measuring method for quickly measuring the contents of heavy metals in tobacco by using a microwave digestion / ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method. According to the measuring method, a microwave digestion pretreatment method is adopted, an ICP-MS is adopted to measure the contents of arsenic, plumbum, cadmium, chromium, copper, zinc, nickel and mercury elements in a digestion liquid, 75As, 208Pb, 111Cd, 53Cr, 63Cu, 66Zn, 60Ni and 202Hg are selected as mass numbers of the to-be-measured elements to reduce mass spectrum interference, and an internal standard element Rh is added in an off-line manner to inhibit the matrix effect. For to-be-measured ions with a certain mass-to-charge ratio, mass spectrum signal response is directly proportional to the number of ions entering the ICP-MS, the concentration of the elements in a sample is measured by measuring the number of mass spectrum signals, and the contents of the elements are calculated by a standard curve method. The method is quick and simple, can efficiently and accurately measure the contents of heavy metals in tobacco and tobacco products, and provides an effective scheme for finding out the content level of heavy metals in cigarettes in China to reduce harm to human health.

The present disclosure provides methods and systems for automated analysis of spectrometry data corresponding to particles of a sample, such as large data sets obtained during single particle mode analysis of an inductively coupled plasma mass spectrometer (SP-ICP-MS). Techniques are presented herein that provide appropriate smoothing for rapid data processing without an accompanying reduction (or with an acceptably negligible reduction) in accuracy and / or precision.

Techniques and systems for maintaining a plasma processing kit consisting of protection and shielding elements without causing damage are introduced. The elements may be made of aluminium, polysilicon and quartz and may be coated with silicon. The surfaces of the elemants show a specified roughness. Precision cleaning and recovery of the contamined kit components of a plasma doping (PLAD) system is used, to extend the life and reusability of the components. The methods described cover the stages of inspection, pre-cleaning, mechanical processing and texturing, post-cleaning, clean-room class cleaning and packaging of the components consisting of quartz, aluminium and / or silicon. Techniques described employ the combination of a variety of means (primarily chemical and mechanical) to achieve the desired levels of cleanliness. The result obtained by methods that include Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Laser Particle Count affirm the efficacy of these techniques.

The invention relates to a method for detecting chromium, nickel, arsenic, selenium, cadmium and lead in cigarette side-stream smoke. The method is characterized in that a fishtail cover is connected with a quartz fiber filter disc in series to collect particulate matters in the cigarette side-stream smoke, a triple-tandem nitrite acid solution is used for collecting gas phase matters in the side-stream smoke, a microwave digestion method is used for digesting samples, and the contents of chromium, nickel, arsenic, selenium, cadmium and lead in the particulate matter and gas phase matter samples are detected through ICP-MS (Inductively Coupled Plasma Mass Spectrometry). The method overcomes the defects of sample collecting and processing methods and detecting techniques in the prior art and fills the blank of domestic detecting techniques for heavy metal in the side-stream smoke. The fishtail cover is connected with the purified quartz fiber filter disc in series to collect the particulate matters in the side-stream smoke, so that the background interference is effectively reduced. A three-stage absorption bottle collects the gas phase matters in the side-stream smoke, so that the gas phase matters can be completely collected. The microwave digestion method treats the samples, so that the digestion effect is good, and the element loss is few. The ICP-MS is adopted for determination, so that the method is fast and accurate, high in sensitivity, good in repeatability and high in recovery rate.

The invention relates to a detection method of selenium forms in plants. The method comprises the steps of: 1, previous preparation of detection: determining instruments and reagents for detection; 2, establishing high performance liquid chromatography and inductively coupled plasma mass spectrometry, that is, HPLC-ICP-MS hyphenated techniques; 3, establishing chromatograms of five selenium form standard solutions; 4, pretreatment of plant samples and extraction and detection of selenium forms: cleaning plant materials to be detected with ultrapure water, carrying out freeze drying, smashing and filtering, measuring the water content, sealing, placing and storing at 4 DEG C for standby; or performing ultrasonic extraction at 37 DEG C for 30 minutes by enzyme immediately, taking supernatant after centrifugalization, detecting the selenium forms according to the HPLC-ICP-MS hyphenated techniques, and calculating the content of selenium forms in plants according to peak areas corresponding to the selenium forms in the samples shown in collected maps. According to the method for detecting the selenium forms in plants, forms are separated completely, pretreatment of samples is simple, convenient and rapid, the moving phase is single in component and simple to prepare, the repeatability and the precision are good, and the quantitative result is accurate and reliable.

The invention discloses a method of digesting, settling and separating tungsten-based samples and a detection method for tungsten-based samples. The method of digesting, settling and separating tungsten-based samples comprises the following steps: putting a tungsten-based sample in a container, adding water and nitric acid into the container, keeping the container airtight, carrying out microwavedigestion and settlement-separation on the sample under gradient temperatures, and restarting microwave for rinsing and deposition after the temperature of the solution decreases and is close to the boiling point of water so as to obtain a sample solution for detection and precipitates of tungstic acid. The detection method for tungsten-based samples in the invention is to analyze the digested sample solution with at least one analytical method selected from the group consisting of inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission spectrometry, flame atomic absorption spectrometry, graphite oven atomic absorption spectrometry and spectrophotometry so as to obtain the content of elements in the tungsten-based sample.

The present invention relates to inductively coupled plasma mass spectrometry (ICPMS) in which a collision cell is employed to selectively remove unwanted artefact ions from an ion beam by causing them to interact with a reagent gas. The present invention provides a first evacuated chamber (6) at high vacuum located between an expansion chamber (3) and a second evacuated chamber (20) containing the collision cell (24). The first evacuated chamber (6) includes a first ion optical device (17). The collision cell (24) contains a second ion optical device (25). The provision of the first evacuated chamber (5) reduces the gas load on the collision cell (24), by minimising the residual pressure within the collision cell (24) that is attributable to the gas load from the plasma source (1). This serves to minimise the formation, or re-formation, of unwanted artefact ions in the collision cell (24).

The invention discloses a method for clearing and detecting vanadic oxide which includes steps as follows: taking vanadic oxide to a container, adding nitric acid to the container, processing pre-action under the normal temperature, then closing the container, processing microwave clearing. The detecting method includes steps as follows: using one or many methods of an inductively coupled plasma mass spectrometry, an inductively coupled plasma atomic emission spectrometry, a flame atomic absorption spectrometry and a graphite furnace atomic absorption spectrometry for analyzing the cleared vanadic oxide, accordingly, obtaining elementary content of vanadic oxide sample.

The invention belongs to the technical field of mass spectrographies, and relates to an ion transmission system for an inductively coupled plasma mass spectrometry. The ion transmission system comprises an ion sampling cone, an interception cone, an extraction lens, an ion deflecting electrode and ion focusing lenses, wherein the centers of all the parts are on coaxial horizontal lines; space electric field distribution is generated under a DC voltage; ions deflect, focus and are transmitted under the action of the electric field; photons and neutral particles in a sample are free from the action of the electric field, transmitted linearly, and blocked while meeting the ion deflecting electrode; electrified ions are guided by the electric field, bypass the ion deflecting electrode, and focus into an ion beam under the action of the electric field of the focusing lenses, and then are transmitted to a mass analyzer. The ion transmission system has the advantages that the structure is simple; the use is convenient; interference signals generated due to the entering of the photons and the neutral particles can be removed effectively; the ion transmission efficiency and the sensitivity of the inductively coupled plasma mass spectrometry are improved.

The invention relates to an application of inductively coupled plasma mass spectrometry in drug testing of hemin. A method for measuring concentration of stable isotope iron in animal plasma is carried out by an ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method and comprises the following steps of: providing an inductively coupled plasma source mass spectrometer; determining operating conditions of the ICP-MS; providing stable isotope iron powder, marked hemin, internal standard elements and the like; preparing standard solution and internal standard solution; preparing ICP-MS diluent; establishing a standard curve; measuring the stable isotope iron concentration in the plasma; and adding the ICP-MS diluent into a sample tube containing animal plasma sample containing iron, mixing uniformly and putting the sample tube into a refrigerator to be refrigerated, and determining the concentration of the iron in the plasma by the obtained standard curve. The application of the inductively coupled plasma mass spectrometry in the drug testing of the hemin has well performances, e.g., the method has well quantification lower limit, accuracy, absolute recovery test, sample stability, medium effect and quality control requirement, and can be taken as a content measurement method for analyzing the content of the stable isotope iron in a biological sample such as the plasma.

The invention relates to a centrifugal micro-fluidic chip for detecting the chromium ion form in a water body and a preparation method of the centrifugal micro-fluidic chip. The centrifugal micro-fluidic chip is a disk type centrifugal micro-fluidic chip with a microstructure and a microchannel; the enriching and separating operation process of a Cr ion in the water body and a miniature centrifugal chromatographic column integrated on the centrifugal micro-fluidic chip is realized by using a centrifugal force generated by rotating a centrifugal machine as a driving force; and the content of total Cr in the water body and the content of Cr<6+> in an extraction solution are respectively detected by an inductively coupled plasma mass spectrometry (ICP-MS), and thus the analysis of the chromium ion form in the water body is realized. The centrifugal micro-fluidic chip realizes the integration, the micromation, the automation and the portability of the chromium ion form detection in the water body; and the centrifugal micro-fluidic chip has the characteristics of fewer reagents and samples, quickness in detection, portability and high parallel detection capability and provides a brand-new analysis technology for detecting the chromium ion form in the environment water body.

The invention relates to a detection method based on selenium form analysis in marine products, in particular to a method for detecting organic selenium, protein selenium or polysaccharide selenium in marine products through microwave digestion-inductively coupled plasma mass spectrometry (ICP-MS) way. The method for detecting organic selenium, protein selenium or polysaccharide selenium in marine products through microwave digestion-ICP-MS way comprises steps as follows: 1, preparing a sample: removing shell of the sample, storing into a sample bag; (1) separating and purifying organic selenium: carrying out a continuous dialysis method to separate and purify the organic selenium; (2) separating and purifying protein selenium; and (3) separating and purifying polysaccharide selenium; and 2, detecting the content of selenium: (1) performing microwave digestion; (2) implementing blank test: processing an agent without being contacted with a sample to be detected according to the method in sub-step (1) of step 2; and (3) detecting by inductively coupled plasma mass spectrometry. The method has the advantages that the organic selenium, the protein selenium or the polysaccharide selenium in the marine products can be efficiently, simply, conveniently and quickly detected.

A method of measuring a plurality of heavy metals in an organic pigment by a microwave digestion-inductively coupled plasma mass spectrometry is disclosed. The method comprises: a first step of preparing agents and materials, a second step of preparing instruments and devices, a third step of preparing standard working solutions, a fourth step of subjecting an organic pigment sample to microwave digestion pretreatment, a fifth step of setting main working parameters of ICP-MS instruments and a sixth step of selecting pretreatment of the sample.

The invention relates to a method for detecting the content of antimony in a cosmetic, in particular to a method for measuring the antimony in the powder cosmetic by a microwave digestion and hydrofluoric acid-resistant sampling system ICP-MS (inductively coupled plasma-mass spectrometry). The method comprises the following steps that: after a cosmetic sample is dispelled by nitric acid, hydrogen peroxide and hydrofluoric acid microwaves, organisms are discomposed; sample solution is introduced into an ICP-MS atomizer; high-temperature high-frequency plasmas are loaded by argon to carry out ionization and generate ions; after being focused, the ions enter the spectrometry; characteristic ion abundances of an antimony element and an on-line internal standard rhodium element in the sample solution are detected, wherein the characteristic ion abundance of the antimony element is directly proportional to the content of the antimony element; according to a ratio of an actually measured rhodium internal standard response value to an expected internal standard response value, correcting the response value of the antimony element; carrying out quantitative measurement by adopting an internal standard calibration curve method; calculating the content of the antimony element in the cosmetic; and obtaining the content of the antimony by a conversion factor. The method disclosed by the invention has the characteristics of strong specificity, high sensitivity and accurate result.

The invention discloses a method for measuring the contents of chromium, nickel, arsenic, selenium, cadmium, mercury and lead in urine. The method comprises the steps as follows: collecting all urine of a smoker in 24 hours; storing in a polypropylene bucket at the temperature of subzero 80 DEG C; disinfecting the urine with microwaves; taking argon gas as carrier gas under acidic condition; measuring by using inductively coupled plasma mass spectrometry; and comparing with standard series and quantifying. The method has the advantages of accurate measurement result, good sensitivity and repeatability and the like, and is simple, convenient and quick to operate.

The invention discloses preparation and application of a covalent organic framework porous nano composite material, and belongs to the technical field of environmental protection. Firstly, 2,4,6-trialdehyde phloroglucinol (Tp) and benzidine (BD) are subjected to a Schiff base reaction under proper conditions to prepare a covalent organic framework (COF-TpBD), then diindium trisulfide (In2S3) nanoparticles are loaded on the COF-TpBD in situ, and the composite material (In2S3@COF) with In2S3 and COF characteristics is obtained. The In2S3@COF prepared by the method is rich in a large amount of Selement and can adsorb Hg2+ through HgS interaction, and on the other hand, the inherent large specific surface area and excellent pore size of the COF can also greatly improve the adsorption capacityto Hg2+. Inductively coupled plasma mass spectrometry test results show that the In2S3@COF has excellent Hg2+ adsorption performance. The method is simple, stable in structure, low in cost, environmentally friendly and high in adsorption and removal efficiency of Hg 2+ in a water body, and can be used as an efficient adsorbent for Hg 2+ in environmental wastewater.

A nebulizer adapted for adjusting a position of a capillary tube contained within the nebulizer is provided. The nebulizer includes an elongated tubular shell having a gas input port and a gas output port, a capillary adjustment adapter for displacing the capillary tube in a lateral direction via a rotational force, and a connector for connecting the elongated tubular shell, the capillary adjustment adapter and the capillary tube.

The invention relates to the technical field of detecting the trace element content, in particular to a method for measuring lead and cadmium contents in the human whole blood. With an ICP-MS method,the lead and cadmium contents in the human whole blood are measured. The method comprises steps of pretreatment of a blood sample and the analysis of an ICP-MS. On the basis of the internal standard method, the lead and cadmium contents in a to-be-detected blood sample are quantified. According to the invention, on the basis of combination of the internal standard method with the ICP-MS method, the accuracy of the quantitative result is improved and the systematic error is eliminated, so that the detection process becomes simple and rapid; the contents of the trace elements in the human wholeblood sample can be reflected accurately; and thus the diagnosis of related diseases can be assisted and the reference for the clinical personalized medicine usage is provided.

The invention discloses a method for detecting heavy metal elements in anti-inflammatory and analgesic bolus, and specifically relates to a method for detecting the heavy metal elements in the anti-inflammatory and analgesic bolus by an inductively coupled plasma mass spectrometric method. The detection method provided by the invention comprises the following steps of: preparing a standard storage solution, preparing a standard solution, preparing a test solution and preparing a reagent blank solution; and through the detection by using the method, the content of Cr is 0.0-1.1 ppm, the content of Cu is 9-26 ppm, the content of Zn is 33-118 ppm, the content of As is 0.6-1.2 ppm, the content of Se is 0.1-0.4 ppm, the content of Cd is 0.1-0.2 ppm, the content of Hg is 0.2-0.4 ppm, and the content of Pb is 3.6-9.6 ppm. The method provided by the invention has the advantages that the method is rapid and simple and has higher sensitivity and wider dynamic linear range, a measuring result is exact and reliable, and the method can be used for detecting heavy metal in the anti-inflammatory and analgesic bolus.

The invention discloses a method for determining a platinum family element antimony assaying microwave digestion inductively coupled plasma mass spectrometry, which comprises the specific flows as follows: the preconcentration of elements to be determined and the determination on microwave digestion assaying composite granules and an inductively coupled plasma mass spectrometry are realized through antimony assaying, and the separate concentration and the assay determination of platinum family elements in rock and mineral samples are realized. In the method for determining the platinum familyelement antimony assaying microwave digestion inductively coupled plasma mass spectrometry, antimony is used as an assaying collector, thus, not only can quantitative collecting on all the platinum family elements be realized but also obvious loss cannot be generated on the platinum family elements when cupellation is carried out; heating is carried out by selecting microwaves, so that the samples can be rapidly and evenly heated; the elements to be determined can be ensured to generate volatilization loss by a non-gas state in the digestion process by matching with an airtight digestion tank, and simultaneously, the digestion tank is also beneficial to forming a high-temperature and high-pressure atmosphere so as to further improve the digestion efficiency. The method for determining theplatinum family element antimony assaying microwave digestion inductively coupled plasma mass spectrometry is suitable for the assay determination on the trace platinum family elements in the rock and mineral samples and has low detection limit, high sensitivity and high analysis speed. The cumulative time for sample assaying, digestion, determination and data processing on a single rock and mineral sample is 3-4 hours on average.

The invention relates to a quick method for simultaneously measuring potassium content, sodium content, calcium content and magnesium content in cigarette paper. The quick method includes the steps of preparing extraction reagents and sample solution, analyzing inductively coupled plasma mass spectrometry, calculating measuring results, and the like. The optimized measuring method has the advantages of being short in measuring time, simple and convenient to operate, high in sensitivity, high in recovery rate and good in repeatability, and the like, and is suitable for volume measurement of important trace inorganic elements in the cigarette paper.

A method for detecting bio-available cadmium in soil includes steps: S100, sample collection and pretreatment, to be more specific, sampling soil, subjecting sampled soil to air drying at the room temperature, grinding, and filtering through a 200-mesh screen to obtain a soil sample; weighing 1-5g of the soil sample, adding into a 250mL polytetrafluoroethylene centrifugal cup, adding 25mL of 1mol / L ammonium chloride solution and 25mL of 80% ethanol solution, cleaning through an ultrasonic cleaner, centrifuging through a centrifuge, filtering supernatant through a filter membrane to obtain extract liquid, and adopting HNO3 solution in concentration of 1% to obtain a constant volume; S200, determination of the concentration of bio-available cadmium in the extract liquid, to be more specific,adopting an inductively coupled plasma source mass spectrometer for creating a standard curve for determining different concentrations of bio-available cadmium according to an inductively coupled plasma mass spectrometry method; adopting the inductively coupled plasma source mass spectrometer for measuring concentration of bio-available cadmium in the extract liquid according to the standard curve; S300, result analysis, to be more specific, calculating the content of bio-available cadmium in the soil sample according to measured soil sample mass and measured extract liquid concentration.

The invention discloses a method for detecting chromium, nickel, arsenic, selenium, cadmium and lead elements in cigarette ashes. The method is characterized in that cigarette ashes are collected by using a cigarette ash plate, a cigarette ash sample is dispelled by adopting a microwave digestion method, and the contents of chromium, nickel, arsenic, selenium, cadmium and lead elements in the cigarette ashes are detected by inductively coupled plasma mass spectrometry. The cigarette ashes are collected by adopting the cigarette ash plate, independent collection of each cigarette ash is achieved on a conventional smoking machine, and loss of cigarette ashes and cross contamination of different cigarette ashes in the smoking process are effectively avoided. The sample is processed by adopting the microwave digestion method, so that the risk caused by use of a perchloric acid in the traditional electric hot plate digestion mode is avoided, the dosage of the acid is reduced, the digestion ability is improved, the method is good in digestion effect, less in element loss, and simple and easy to operate, and the used mixed acid system is applicable to treatment of the cigarette ash sample, and thorough to digest. The interference is effectively corrected by adopting inductively coupled plasma mass spectrum parameters, and the method is high in sensitivity, good in repeatability, high in recovery rate, and accurate in result.

The invention relates to a method for determining a content of germanium in a plus material by using an inductively coupled plasma mass spectrometry. The method comprises the following steps: preparing instruments and reagents; preparing a calibration solution; preprocessing a sample; testing; determining the sample and a standard solution; calculating the content of germanium in the plus material; and obtaining the content of the germanium in a textile test sample according to a calculation result. By adopting the method, the detection limit of the germanium is 0.02 microgram / g, and adding standard recovery at different concentrations is 85 percent to 115 percent. The method has the advantages of rapidness, high sensitivity and good accuracy.

A method for determining heavy metal loading in a subject includes collecting a saliva sample from the subject containing a concentration of a heavy metal. The saliva sample is subjected to inductively coupled plasma mass spectrometry to yield a heavy metal loading measurement for the subject. The saliva sample is readily collected on a substrate absorbing a preselected amount of saliva such as filter paper. As the amount of saliva necessary to saturate a given volume of substrate is known, the volume of saliva within a substrate is also known. The resulting heavy metal loading measurement is readily correlated with a blood level for the heavy metal in the subject.

The invention discloses a sample pretreatment method based on flow combination ICP-MS (Inductively Coupled Plasma Mass Spectrometry) single cell protein detection, and belongs to the technical field of sample pretreatment of flow cytometry. The sample pretreatment method comprises the following steps: (1) collecting and transporting a whole blood sample; (2) performing PBMC (Peripheral Blood Mononuclear Cell) cell separation; (3) performing cell active dyeing; (4) performing cell stimulation; (5) performing cell immobilization; (6) performing surface antibody dyeing; (7) performing intracellular phosphorylated protein dyeing; (8) performing single cell labeling, and the like. With the combination of a metal element labeled antibody with cell surface antigen, labeled cells are mixed with beads as internal reference for standardization, dead cells and living cells are distinguished in the pretreatment process, then the situation that the testing result analysis and description are affected by too many dead cells is avoided, single cells are distinguished from cell dimmers, cell trimers or even cell multimers, and flow combination ICP-MS single cell protein detection requirements can be very well met.