Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

39 results about "Hepatic disposition" patented technology

Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction

A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and / or to develop and monitor the outcome of therapeutic treatments. An exemplary disease / condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.
Owner:VIRGINIA COMMONWEALTH UNIV +1

Bifidobacterium cect 7765 and use thereof in the prevention and/or treatment of excess weight, obesity and related pathologies

The invention relates to Bifidobacterium CECT 7765 and to the use thereof in the prevention and / or treatment of overweight, obesity and related pathologies. The invention likewise relates to the Bifidobacterium CECT7765 strain, to the cellular components, metabolites and secreted molecules thereof, to the combinations thereof with other microorganisms, and to compositions that include the preceding products, as well as to the use of one strain of the species Bifidobacterium pseudocatenulatumo and to the use of the CECT 7765 strain for preventing and / or treating obesity; excess weight; hyperglycemia; and diabetes, preferably type-2 Diabetes Mellitus; hepatic steatosis or fatty liver; dyslipidemia; metabolic syndrome; immune system dysfunction associated with obesity and excess weight; and an imbalance in the composition of the intestinal microbiota associated with obesity and excess weight.
Owner:CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof

The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and / or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and / or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.
Owner:APHAIA PHARMA AG +1

Treatment of hepatic encephalopathy and liver cirrhosis

The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD +2

Medical formula food for hepatic encephalopathy

The invention belongs to the technical field of medicine and food homologous formula and new resource food and particularly provides a medical formula food or specific medical formula food or non-specific medical formula food eaten by patients suffering from hepatic encephalopathy. According to the formula, according to the requirements of the General Rule for Special medical Purpose Formula Food and in combination of the constitutive characters of patients suffering from hepatic encephalopathy, various medicine and food homologous Chinese herbs are in reasonable compatibility according to the traditional Chinese medicine essence theory, medicine and food homologous traditional Chinese medicine extract essence extracted with a semi-bionic extracting method, various microencapsulated probiotics, oligopeptide extracted through biological enzymolysis, prebiotics, amino acid, carbohydrate, grease with the health-care function, various vitamins and mineral substances are mixed together and subjected to other processes, and the medical formula food is prepared. The medical formula food can serve as a single nutrition source to meet the nutrition needs of patients suffering from hepatic encephalopathy, and further performs the effects of strengthening the spleen and tonifying the lung, benefiting the bile and protecting the liver, nourishing yin and the liver, nourishing the liver and relieving pain, and boosting immunity.
Owner:JINSHANMEI BIOTECH

L-ornithine phenyl acetate and methods of making thereof

Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
Owner:OCERA THERAPEUTICS INC

Drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and preparation of drug

The invention provides a drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and a preparation of the drug. The drug is characterized in that the drug inhibits the activity of an intestinal bacterial BSH enzyme and increases the level of conjugated bile acid in anthe intestinal tract, thus the activity of FXR of bile acid receptors FXR is inhibited, synthesis of liverbile acid is improved, and the level of liver cholesterol and triglyceride is decreased; and the drug comprises amide derivatives form by carboxyl in ursodesoxycholic acid (UDCA) or chenodeoxycholic acid (CDCA) steroid stem nucleus and amidogen in other amino acids in addition except for glycine and taurine, and thus blood glucose, dyslipidemia, fatty liver, hepatic encephalopathy and neurodegenerative diseases such as senile dementia can be treated.
Owner:SHENZHEN YUNHE PHARM TECH PARTNERSHIP LTD

Slow-release preparation of ornithine aspartate and preparation process thereof

The invention provides a slow-release preparation of ornithine aspartate, the slow-release preparation comprises major components of the ornithine aspartate and an auxiliary additive, and controlled release of active ingredients in the preparation can be realized by the auxiliary additive. The preparation prepared into a capsule preparation formulation overcomes the defects that other ornithine aspartate preparations such as an injection are high in concentration, inconvenient to store and transport, and difficult to use for a patient by oneself, and the preparation has the advantages of convenience for middle and old age patients to take, quick absorption, high biological utilization rate and the like. The slow-release preparation of the ornithine aspartate is suitable for blood ammonia rising caused by acute and chronic liver diseases (such as various types of hepatitis, liver cirrhosis, fatty liver and post-hepatitis syndrome) and treatment of hepatic encephalopathy such as potential or attack-stage hepatic encephalopathy accompanying with or secondary with liver detoxification function damage (such as liver cirrhosis), and is especially suitable for the treatment of consciousness clouding state and other diseases in an early hepatic coma period and a hepatic coma period.
Owner:BENGBU BBCA MEDICINE SCI DEV

Medicine composition for curing hepatic encephalopathy and hepatitis B

InactiveCN102008588ADetoxifyingCooling blood and removing blood stasisNervous disorderDigestive systemToxic materialPharmaceutical Substances
The invention provides a medicine composition for curing hepatic encephalopathy and hepatitis B, belonging to the field of Chinese materia medica prescriptions. The composition comprises the following components in parts by weight: 5-50 parts of rheum officinale, 10-60 parts of roxburgh rose root, 5-30 parts of black soya bean, 20-90 parts of serissa serissoide, 20-100 parts of Salviacavaleriei, 30-150 parts of siphonostegia chinensis, 5-40 parts of pubescent holly root and 10-60 parts of liquorice. In the medicine composition, pathogenesis and symptomatic treatment are taken as the principal thing; the medicine composition has the efficacies of clearing away heat and toxic material, removing dampness through diuresis, cooling blood, eliminating stasis, stop bleeding, eliminating heat and relaxing the bowels, thus achieving the effects of resisting viruses, cooling the blood, reducing bloodammonia, eliminating excreta reserved in bowel, reducing absorption of toxin in intestinal tracts, protecting a liver and a brain, and preventing and curing the encephalopathy and the hepatitis B.
Owner:张蕊

New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease

The invention discloses new application of sodium copper chlorophyllin to preparation of medicines for treating liver disease. Acute liver failure is caused by severe liver damage due to various factors, and can lead to acute necrosis and apoptosis of liver cells to show a group of clinical syndromes mainly represented by disturbances of blood coagulation, jaundice, hepatic encephalopathy, ascites and the like, and moreover, inflammatory response, particularly proinflammatory factors in a liver, plays a key role in incidence, deterioration and cure of the disease, so that slowing the inflammatory response can be one of approaches for adjuvant therapy of acute liver failure. Sodium copper chlorophyllin provided by the invention can inhibit interleukin-1 and interleukin-6 in liver tissues, as well as tumor necrosis factor alpha in the liver tissues. Experiments show that sodium copper chlorophyllin can be used to preparation of the medicines for treating liver disease.
Owner:CHENGDU TONGDE PHARMA

Sorting method of hepatocytes of which embryonic hepatic cells are differentiated

The invention belongs to the technical field of cell culture, and in particular relates to a sorting method of hepatocytes of which embryonic hepatic cells are differentiated. According to the sorting method, the embryonic hepatic cells are cultured into embryoid bodies in a shaking or suspension culture mode, then the embryoid bodies are cultured in an adherent culture mode, so as to gradually grow and differentiate into round differentiated cell communities, and cells in a specific area are selected to be sorted in a specific period and are cultured again in the adherent culture mode according to spatial distribution regularities of the differentiated hepatic cells in the round cell communities. In the process of adherent culture, according to a cell differentiation situation, EGFs (Epidermal Growth Factor), TGFs (Transforming Growth Factor), HGFs (Hepatocyte Growth Factor), OSMs and the like are selected as hepatic growth factors in the process that the embryoid bodies are differentiated into the hepatocytes, so as to promote the hepatocytes to differentiate, the whole sorting process has the advantages of simplicity in operation and low cost, cellular damage can be obviously reduced, compared with the prior art, the hepatic cell differentiation rate is greatly increased, the sorted cells grow with good conditions, and the cell purity and the cell functional requirements of hepatocyte transplantation can be satisfied.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

Application of common goldenrop soup in preparing medicine for treating hepatic encephalopathy

The invention discloses application of common goldenrop soup in preparing a medicine for treating hepatic encephalopathy, in particular discloses application of the common goldenrop soup in preparinga medicine for treating type-A hepatic encephalopathy, and belongs to the technical field of application of traditional Chinese medicines. The common goldenrop soup disclosed by the invention is madeof radix bupleuri, scutellaria baicalensis, ginger processed pinellia, codonopsis pilosula, ginger, licorice roots and dates. The common goldenrop soup is orally taken, the medicine liquid is fed intoblood, the amounts of glutamine synthetase (GS) and malonaldehyde (MDA) for reflecting a lipid peroxidation degree in brain tissue are reduced by reducing the amount of ammonia in peripheral blood, and brain functions and liver functions of hepatic encephalopathy are improved by improving activity of superoxide dismutase (SOD) for reflecting the lipid peroxidation degree, so that the purpose of treating hepatic encephalopathy is achieved, and the common goldenrop soup is definite in treatment effect, good in compliance and applicable to clinical popularization.
Owner:ZUNYI MEDICAL UNIVERSITY

Non-complete-nutrient formula food for hepatopathy, and preparation method and application thereof

The invention provides a non-complete-nutrient formula food for hepatopathy. The food is prepared from 20g of amino acid, 2.5g of isomaltooligosaccharide, 26.6832g of maltodextrin, 0.1238g of vitamin and 0.6930g of mineral. The invention also provides a preparation method of the formula food and application of the formula food in the aspect of adjuvant treatment of hepatocirrhosis and hepatic encephalopathy. The formula food has favorable adjuvant treatment effects on hepatocirrhosis and hepatic encephalopathy.
Owner:SICHUAN UNIV

Use of rhein in preparation of drugs for prevention and treatment of hepatic encephalopathy

The invention relates to the technical field of medicine, in particular to the use of rhein in the preparation of drugs for prevention and treatment of hepatic encephalopathy. The application of rheinin the preparation of drugs for preventing and treating hepatic encephalopathy is disclosed for the first time. The model of hepatic encephalopathy induced by thioacetamide (TAA) and carbon tetrachloride (CCL4) was tested repeatedly. The results showed that rhein could reduce blood ammonia, alleviate inflammation of liver and brain tissue, protect liver function, reduce liver necrosis and improveliver injury and brain injury. Therefore, rhein or its salts can be used to prepare drugs for the prevention and treatment of hepatic encephalopathy. Rhein or its salts can be used as active ingredients to prevent and cure hepatic encephalopathy, which has the advantages of obvious effect, less dosage and quick onset.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M

Medicine composition for treating hepatic encephalopathy and hepatitis B

The invention provides a more effective pure traditional Chinese medicine composition for treating hepatic encephalopathy and hepatitis B and belongs to the field of Chinese medicinal formulae. The medicine composition comprises raw materials, by weight, 5 to 50 parts of rheum officinale, 10 to 60 parts of roxburgh rose roots, 5 to 30 parts of black beans, 20 to 90 parts of serissa japonica, 20 to 100 parts of salvia prionitis hance, 30 to 15 parts of siphonostegia chinensis, 5 to 40 parts of pubescent holly roots, 10 to 60 parts of liquorice. The medicine composition mainly accords with pathogenesis and symptomatic treatment, the effects of clearing away heat and toxic materials, promoting diuresis, cooling the blood, removing stasis, stopping bleeding, removing heat and facilitating excrement excretion are achieved, so that the functions of resisting viruses, cooling the blood, stopping bleeding, reducing blood ammonia, facilitating excrement excretion, reducing toxin absorption in the intestines, protecting the livers and the brain and preventing and treating hepatic encephalopathy and hepatitis B are achieved.
Owner:张蕊

Active salt of dipeptide compound of ornithine and aspartic acid and application thereof

The present invention provides active salts of ornithine and aspartate dipeptide compounds, preparation methods thereof, pharmaceutical compositions comprising the active salts, and preparation of the dipeptide compounds or their active salts for preventing or treating hyperemia Use in the medicament of ammonia disease or liver disease, especially hepatic encephalopathy. The test results clearly show that the ornithine and aspartate dipeptide compounds and their active salts of the present invention can significantly reduce blood ammonia concentration after administration, and can significantly improve the memory secondary to TAA-induced liver injury in rats. It means that the dipeptide compound and its active salt have a certain therapeutic effect on hyperammonemia or liver disease, especially hepatic encephalopathy.
Owner:NANJING YOUKE BIOLOGICAL MEDICAL RES +3

A method for supercritical extraction of squid active protein high f-value oligopeptides

The invention belongs to the technical field of health food processing. The invention discloses a method for supercritically extracting squid active protein high F value oligopeptides, which comprises the steps of squid pretreatment, supercritical extraction, enzymolysis, purification and powder making. In the present invention, the supercritical carbon dioxide fluid extraction technology can effectively remove the lipids and smelly and miscellaneous substances in squid protein, and obtain active low-fat squid protein. At the same time, two-step ultrasonic assisted enzymatic hydrolysis fundamentally ensures high The quality of the F-value oligopeptide, the synergy between the various steps and parameters of the method of the present invention can ensure the quality of the high-F-value oligopeptide product; the high-F-value oligopeptide obtained by the present invention is a small molecular short peptide, Compared with free amino acids, it has the advantages of low osmotic pressure and low antigenicity, and is easier to be absorbed and utilized. It can be used as a nutritional supplement for athletes, and has significant effects in liver protection, hepatic encephalopathy, and phenylketonuria treatment.
Owner:ZHEJIANG OCEAN UNIV

Active salt of dipeptide compound of ornithine and aspartic acid as well as application thereof

The invention provides active salt of a dipeptide compound of ornithine and an aspartic acid, a preparation method of the active salt, a pharmaceutical composition including the active salt, and application of the dipeptide compound or the active salt thereof in preparation of medicine for preventing or treating hyperammonemia or liver diseases, in particular to hepatic encephalopathy. A test result clearly indicates that after the dipeptide compound of the ornithine and the aspartic acid and the active salt of the dipeptide compound are administered, the concentration of blood ammonia can beobviously reduced, and secondary memory disorder after TAA(tumor-associated antigen)-induced liver injury in rats can be obviously improved, indicating that the dipeptide compound and the active saltof the dipeptide compound have a certain treatment effect on hyperammonemia or liver diseases, in particular to the hepatic encephalopathy.
Owner:NANJING YOUKE BIOLOGICAL MEDICAL RES +3

Application of fxr agonists in the treatment of hepatic encephalopathy

The invention belongs to the technical field of biomedicine, and in particular relates to the application of FXR agonists in the treatment of hepatic encephalopathy, specifically the application of obeticholic acid in the treatment of hepatic encephalopathy. The present invention also provides the application of the nuclear receptor FXR in the treatment of hepatic encephalopathy, specifically targeting the nuclear receptor FXR to obtain a drug for treating hepatic encephalopathy or protecting the liver. Using the FXR agonist obeticholic acid (OCA) to activate FXR, we found that in the liver injury model, the activation of FXR can induce the expression of key enzymes in the ammonia metabolism pathway such as NAGS, SLC1A4, AL, and reduce the blood ammonia content. Reduce the damage of brain astrocytes; in addition, the activation of FXR can play a significant role in liver protection.
Owner:HENAN UNIVERSITY

All-in-one acetic acid enema

The invention discloses an integrated acetic acid enema, comprising a cover body, a liquid discharge mechanism, a liquid storage mechanism, a liquid inlet mechanism, a slide bar, a limit plate and a fixing mechanism. The integrated acetic acid enema can mix acetic acid solution and physiological saline The classification and storage process is carried out, so that the medical staff can conveniently pour the classified acetic acid solution and physiological saline into the body of the patient. By using the device in this application, the preparation time and operation time of the medical staff can be shortened, and labor costs can be saved, At the same time, it can precisely control the depth of the enema, prolong the retention time of the enema solution, continuously reduce the intestinal HP, reduce the absorption of blood ammonia, make the blood ammonia level drop faster, and shorten the treatment time required for the improvement of hepatic encephalopathy. In addition, the device is convenient for patients. At home, it can reduce the number of hospitalizations due to hepatic encephalopathy and the medical expenses of patients with liver cirrhosis.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Application of intestinal flora in hepatic encephalopathy detection

The invention relates to an application of intestinal flora in hepatic encephalopathy detection. The intestinal flora comprises enterohemorrhagic Escherichia coli, gemella haemolysans and Helcococcus kunziii. The level change of the specific flora in the hepatic encephalopathy is found for the first time, the hepatic encephalopathy can be diagnosed by detecting the change of the specific flora, and when the microbial marker is used for diagnosis, the operation is simple, the specificity is high, and the sensitivity is strong.
Owner:RUIAN PEOPLES HOSPITAL +1

Application of FXR agonist in treatment of hepatic encephalopathy

The invention belongs to the technical field of biological medicine, and particularly relates to application of an FXR agonist in treatment of hepatic encephalopathy, particularly to application of obeticholic acid in treatment of hepatic encephalopathy. The invention also provides the application of the nuclear receptor FXR in treatment of hepatic encephalopathy, and particularly, a drug for treating hepatic encephalopathy or protecting the liver is obtained through adoption of the nuclear receptor FXR as a target spot. The FXR is activated by an FXR agonist obeticholic acid (OCA), and in a liver injury model, expression of NAGS, SLC1A4, AL and other key enzymes of ammonia metabolic pathways is induced through activation of the FXR, the content of blood ammonia in blood can be reduced, and injuries to brain astrocyte are reduced; and moreover, through the liver can be protected significantly through activation of the FXR.
Owner:HENAN UNIVERSITY

Application of intestinal flora in the detection of hepatic encephalopathy

The invention relates to the application of intestinal flora in the detection of hepatic encephalopathy, and the intestinal flora is enterohemorrhagic Escherichia coli, hemolytic twin coccus and Kenzian traumatococcus. The present invention discovers the level change of specific flora in hepatic encephalopathy for the first time. By detecting the change of specific flora, the diagnosis of hepatic encephalopathy can be realized. Using the microbial markers of the present invention for diagnosis has simple operation, high specificity, Strong sensitivity.
Owner:RUIAN PEOPLES HOSPITAL +1

Dietary composition for preventing and treating hepatic sarcopenia and preparation method thereof

The invention discloses a dietary composition for preventing and treating hepatic sarcopenia and a preparation method thereof. The composition comprises the following components in parts by mass: 5-15parts of a black Chinese wolfberry powder extract; 5-15 parts of a schisandra chinensis powder extract; 2.5-5 parts of licorice root extract powder; 10-30 parts of leucine; 5-7.5 parts of arginine; 1.5-2.25 parts of lysine; 5-10 parts of glutamine; 10-30 parts of maltodextrin; 5-10 parts of medium chain triglyceride; 0.2-0.5 part of vitamin C; 0.01-0.02 part of vitamin E; 0.0024-0.0046 part of vitamin B; 6*10<-6>-10*10 <-6> parts of vitamin D; 3*10<-5>-5*10<-5> parts of selenium; 0.008-0.015 part of zinc; and 0.1-0.3 part of magnesium. The composition has the effects of protecting liver, resisting inflammation and resisting oxidation, cooperates with protein to promote muscle protein synthesis, and hinders muscular reduction.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Dosage and use of ornithine phenylacetate for treating hyperamminemia

PendingCN114786662AOrganic active ingredientsDigestive systemOrnithine phenylacetateHyperammonemia
Embodiments of the present disclosure relate to doses of ornithine phenylacetate for use in treating or ameliorating hyperammonemia and methods of administering such doses of ornithine phenylacetate in patients suffering from chronic liver disease, such as cirrhosis. In some embodiments, the patient also has hepatic encephalopathy as a complication of the liver disease.
Owner:OCERA THERAPEUTICS INC +1

Acylated derivatives of ornithine and aspartic acid dipeptide compounds and their application

The invention provides an acylated derivative for an ornithine and aspartate dipeptide compound or an officinal salt thereof, a preparation method thereof, a medicine composition containing the derivative or the officinal salt thereof, and the application of the derivative or the officinal salt thereof for preparing medicines for preventing or curing hyperammonemia or liver diseases, particularlyhepatic encephalopathy. Experimental results definitely indicate that the concentration of blood ammonia can be obviously reduced after administration for the acylated derivative for the ornithine andaspartate dipeptide compound, the acylated derivative takes effect quickly by preferably compared with LOLA, subsequent dysmnesia after TAA-induced rat liver injury can be obviously improved, and theacylated derivative for the dipeptide has a certain treatment effect on hyperammonemia or liver diseases, particularly hepatic encephalopathy.
Owner:NANJING YOUKE BIOLOGICAL MEDICAL RES +3

Food based delivery of therapeutic agent for treatment of hepatic encephalopathy

Described herein are compositions, methods, and kits for treating hepatic encephalopathy. A composition for treating or preventing hepatic encephalopathy comprises one or more therapeutic agents and adelivery modality comprising an edible food, beverage, candy, or gum. The one or more therapeutic agents are mixed with one or more food ingredients so that the therapeutic agent is incorporated in the delivery modality.
Owner:COLONARYCONCEPTS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products