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New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease

A technology for sodium copper chlorophyll and liver disease, which is applied in the field of medicine

Inactive Publication Date: 2015-12-16
CHENGDU TONGDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research report on the treatment of liver diseases with sodium copper chlorophyllin as the active ingredient or drugs containing sodium copper chlorophyllin

Method used

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  • New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease
  • New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease
  • New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Materials and methods

[0028] 1.1 Materials

[0029] Male C57BL / 6 and BALB / C mice were provided by Beijing Huafukang Biotechnology Co., Ltd.; chlorophyllin copper sodium powder was provided by Chengdu Tongde Pharmaceutical Co., Ltd., and the molecular formula is C 34 h 29 CuN 4 Na 3 o 6 , molecular weight: 722.13, CAS number: 65963-40-8; bacterial lipopolysaccharide (LPS), D-galactosamine (D-Gal), carbon tetrachloride (CCl 4 ) and mineral oil were provided by sigma; methionine choline deficiency (MCD) feed was provided by Nantong Trofee Feed Technology Co., Ltd.

[0030] 1.2 Reagent preparation

[0031] Sodium copper chlorophyllin agent: Add 50ml sterilized ultrapure water and 100mg sodium copper chlorophyllin powder to a 50ml sterilized centrifuge tube in turn in the ultra-clean workbench, vortex to mix and store at 4C.

[0032] 1.3 Establishment of acute liver failure model in experimental animals

[0033]3-4 week old male C57BL / 6 mice were fed with normal...

Embodiment 2

[0040] Example 2: Oral administration of sodium copper chlorophyllin can effectively prevent the development of inflammation in liver fibrosis

[0041] 2.1 Materials

[0042] Male BALB / C mice were provided by Beijing Huafukang Biotechnology Co., Ltd.; sodium copper chlorophyllin powder was provided by Chengdu Tongde Pharmaceutical Co., Ltd., and the molecular formula is C 34 h 29 CuN 4 Na 3 o 6 , molecular weight: 722.13, CAS number: 65963-40-8; carbon tetrachloride (CCl 4 ) and mineral oil are provided by sigma;

[0043] 2.2 Reagent preparation

[0044] Sodium copper chlorophyllin agent (mother liquor): Add 50ml of sterilized ultrapure water and 100mg of sodium copper chlorophyllin powder into a 50ml sterilized centrifuge tube in turn in the ultra-clean workbench, vortex to mix and store at 4°C.

[0045] CCl 4 Injection: add 0.75ml, 2.25ml, 3.75mlCCl4 and 14.25ml, 12.75ml, 11.25ml of mineral oil into 15ml sterilized centrifuge tubes in the ultra-clean workbench resp...

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Abstract

The invention discloses new application of sodium copper chlorophyllin to preparation of medicines for treating liver disease. Acute liver failure is caused by severe liver damage due to various factors, and can lead to acute necrosis and apoptosis of liver cells to show a group of clinical syndromes mainly represented by disturbances of blood coagulation, jaundice, hepatic encephalopathy, ascites and the like, and moreover, inflammatory response, particularly proinflammatory factors in a liver, plays a key role in incidence, deterioration and cure of the disease, so that slowing the inflammatory response can be one of approaches for adjuvant therapy of acute liver failure. Sodium copper chlorophyllin provided by the invention can inhibit interleukin-1 and interleukin-6 in liver tissues, as well as tumor necrosis factor alpha in the liver tissues. Experiments show that sodium copper chlorophyllin can be used to preparation of the medicines for treating liver disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of sodium copper chlorophyllin in the preparation of medicines for treating liver diseases. Background technique [0002] The mechanisms of acute liver failure can be divided into two categories at the cellular level. First, various pathogens and toxic substances directly damage liver parenchymal cells (hepatocytes), or activate the apoptosis signaling pathway, leading to the death of liver cells. Second, the overreaction of the immune system leads to the damage of liver cells through the indirect action of inflammatory cells and inflammatory factors. These two types of mechanisms can be considered at intracellular and intercellular levels, respectively. But in the final analysis, the root cause of acute liver failure is cell death, including apoptosis, autophagy and necrosis. There are some differences in the phenomena among the three: apoptosis will cause chromati...

Claims

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Application Information

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IPC IPC(8): A61K31/409A61P1/16A61P31/12
Inventor 韩源平郑翰范伟川
Owner CHENGDU TONGDE PHARMA
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