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Drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and preparation of drug

A technology for neurodegenerative and dyslipidemia, applied in the field of biology and medicine, to increase the synthesis of bile acids in the liver, inhibit the activity of FXR, and reduce the level

Pending Publication Date: 2019-02-22
SHENZHEN YUNHE PHARM TECH PARTNERSHIP LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the study only focused on obesity, insulin resistance and metabolic diseases, and did not involve non-alcoholic fatty liver, hepatic encephalopathy, and neurodegenerative diseases such as Alzheimer's

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  • Drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and preparation of drug
  • Drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and preparation of drug
  • Drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and preparation of drug

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Embodiment Construction

[0032] In order to make the object, technical solution and effect of the present invention more clear and definite, the present invention will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0033] The invention provides a medicine for treating blood sugar, dyslipidemia and neurodegenerative diseases, which is characterized in that the medicine increases the level of bound bile acid in the intestine by inhibiting the activity of intestinal bacterial BSH enzyme , to inhibit bile acid receptor FXR activity, increase hepatic bile acid synthesis, thereby reducing liver cholesterol and triglyceride levels, the drug includes the carboxyl group in the UDCA or CDCA steroid core and other substances except glycine and taurine Amide derivatives formed by amino groups in amino acids, so as...

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Abstract

The invention provides a drug for treatment of blood glucose, dyslipidemia and neurodegenerative diseases and a preparation of the drug. The drug is characterized in that the drug inhibits the activity of an intestinal bacterial BSH enzyme and increases the level of conjugated bile acid in anthe intestinal tract, thus the activity of FXR of bile acid receptors FXR is inhibited, synthesis of liverbile acid is improved, and the level of liver cholesterol and triglyceride is decreased; and the drug comprises amide derivatives form by carboxyl in ursodesoxycholic acid (UDCA) or chenodeoxycholic acid (CDCA) steroid stem nucleus and amidogen in other amino acids in addition except for glycine and taurine, and thus blood glucose, dyslipidemia, fatty liver, hepatic encephalopathy and neurodegenerative diseases such as senile dementia can be treated.

Description

technical field [0001] The invention belongs to the fields of medicine and biotechnology, and in particular relates to a medicine for treating blood sugar, blood fat abnormality and neurodegenerative diseases and a preparation thereof. Background technique [0002] Fatty liver is a liver lesion with more than 5% fat accumulation in the liver due to various reasons. Fatty liver mainly includes alcoholic liver disease, non-alcoholic fatty liver disease, and various special types of fatty liver. Among them, the onset of non-alcoholic fatty liver appears young and universal, and the incidence rate continues to rise, and has reached about 20% at present, becoming a serious health problem that threatens human beings worldwide. In recent years, more and more studies have shown that intestinal flora has undergone significant changes in the occurrence and development of fatty liver, steatohepatitis, liver fibrosis, liver cirrhosis, and liver cancer. During the whole pathological pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/216A61K31/525A61K31/192A61K31/353A61K31/05A61K31/165A61K31/343A61P3/10A61P3/06A61P25/00A61P1/16
CPCA61K31/575A61K31/05A61K31/165A61K31/192A61K31/216A61K31/343A61K31/353A61K31/525A61P1/16A61P3/06A61P3/10A61P25/00A61K2300/00
Inventor 贾伟谢国祥赵爱华郑晓皎
Owner SHENZHEN YUNHE PHARM TECH PARTNERSHIP LTD
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