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Application of common goldenrop soup in preparing medicine for treating hepatic encephalopathy

A technology of hepatic encephalopathy and Xiaochaihu Decoction, applied in the application field of Xiaochaihu Decoction in the preparation of drugs for treating hepatic encephalopathy, which can solve problems such as stickiness, limited treatment methods, and hyponatremia

Inactive Publication Date: 2019-01-04
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inducing factors of hepatic encephalopathy are complicated, and the current treatment methods are limited. Modern medical treatment of hepatic encephalopathy mostly focuses on intestinal detoxification and reducing the absorption of toxins. Long-term use of lactulose is the first choice for treatment, but long-term use will inevitably lead to abdominal pain. Flatulence and sticky mouth, and a series of serious complications such as dehydration and hyponatremia

Method used

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  • Application of common goldenrop soup in preparing medicine for treating hepatic encephalopathy
  • Application of common goldenrop soup in preparing medicine for treating hepatic encephalopathy
  • Application of common goldenrop soup in preparing medicine for treating hepatic encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] Further detailed explanation through specific implementation mode below:

[0027] 1 Establish a rat type A hepatic encephalopathy model, and observe the therapeutic effect of Xiaochaihu Decoction on rat type A hepatic encephalopathy:

[0028] 1.1 Modeling method

[0029] 50 clean-grade SD rats, male, weighing 200±20g, were randomly divided into 5 groups after one week of adaptive feeding, 10 rats in each group, respectively ① blank control group (vehicle group); ② model group (TAA group); ③Xiaochaihu decoction high dose group (XCHT, 4g / kg); ④Xiao Chaihu decoction medium dose group (XCHT, 2g / kg); ⑤Xiao Chaihu decoction low dose group (XCHT, 1g / kg). Except for the blank control group, the rats were intraperitoneally injected with thioacetamide (TAA, 250 mg / kg / day) dissolved in normal saline for 2 consecutive days to prepare the AHE model. The blank control group was given intraperitoneal injection of the same amount of normal saline. Fasting without food and water for ...

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Abstract

The invention discloses application of common goldenrop soup in preparing a medicine for treating hepatic encephalopathy, in particular discloses application of the common goldenrop soup in preparinga medicine for treating type-A hepatic encephalopathy, and belongs to the technical field of application of traditional Chinese medicines. The common goldenrop soup disclosed by the invention is madeof radix bupleuri, scutellaria baicalensis, ginger processed pinellia, codonopsis pilosula, ginger, licorice roots and dates. The common goldenrop soup is orally taken, the medicine liquid is fed intoblood, the amounts of glutamine synthetase (GS) and malonaldehyde (MDA) for reflecting a lipid peroxidation degree in brain tissue are reduced by reducing the amount of ammonia in peripheral blood, and brain functions and liver functions of hepatic encephalopathy are improved by improving activity of superoxide dismutase (SOD) for reflecting the lipid peroxidation degree, so that the purpose of treating hepatic encephalopathy is achieved, and the common goldenrop soup is definite in treatment effect, good in compliance and applicable to clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of application of traditional Chinese medicinal materials, and in particular relates to the application of Xiaochaihu Decoction in the preparation of medicines for treating hepatic encephalopathy. Background technique [0002] Hepatic encephalopathy (HE), also known as hepatic encephalopathy, has become a global problem affecting people's healthy life, and it is also one of the more common serious complications of liver diseases. The exact incidence of hepatic encephalopathy is still difficult to estimate, but my country is a country with a large number of liver diseases, and the number of patients with chronic liver diseases is very large, many of whom will gradually develop into liver cirrhosis, and most patients with liver cirrhosis will develop liver cirrhosis at some stage during the course of the disease. Symptoms of hepatic encephalopathy vary in degree, and the incidence of hepatic encephalopathy may ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/16A61P25/00
CPCA61K36/233A61K36/344A61K36/484A61K36/539A61K36/725A61K36/8888A61K36/9068A61P1/16A61P25/00A61K2300/00
Inventor 李晋徐尚福贾为壹
Owner ZUNYI MEDICAL UNIVERSITY
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