63 results about "Extraction drug" patented technology

A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a hydrophilic vehicle. The primary rate controlling barrier can further comprise one or more solvents which are miscible with the hydrophilic vehicle. The secondary rate controlling barrier includes a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle. The presence of the hydrogel-forming polymeric material makes extraction of the drug from the dosage form more difficult. This feature could be beneficial in preventing or minimizing the misuse of dosage forms which contain drugs which are prone to abuse.

The present invention relates to a Chinese medicine yanming qingsongtie plaster with the function of making eye and its peripheral muscle, nerve and blood vessel obtain regulation and improvement and its preparation method. The described Chinese medicine yanming qingsongtie plaster includes the back lining layer, medicine layer, pressure-sensitive layer and protective layer, and its preparation method includes the following steps: aluminium-plating polyester film or silk cloth to prepare back lining layer, extracting effective components of four Chinese medicines of ligusticum root, salvia root, Chinese angelica root and chrysanthemum flower to preparing medicine layer, coating pressure-sensitive adhesive, covering protective layer and cutting, etc.

This invention provides a process for extracting a pharmaceutically active fraction from the foliage (leaves and stems) and / or roots of Rauvolfia vomitoria and the fruit of Citrus aurantium. In one aspect, the process requires extracting from a boiled tea of Rauvolfia vomitoria foliage and / or roots and Citrus aurantium fruit an active fraction made by filtering the boiled tea and concentrating the supernatant. In one embodiment, the fraction is concentrated by freeze drying the supernatant. The fraction is useful to treat a disorder associated with abnormally elevated glucose levels in a subject by administering to the subject a therapeutically effective amount of the extract or a pharmaceutical composition containing the extract. Such conditions include, but are not limited to the diabetes Type II, abnormal steraroyl-CoA desaturase activity, hyperphagia, abnormal lipid mobilization, abnormal fatty acid profile from the eye of the subject, ulcers and a glucosuria.

The invention provides a graph convolution drug pair interaction prediction method based on a knowledge graph. The method comprises the following steps: extracting drug pair data samples, and generating a data set comprising a training set, a verification set and a test set; constructing a knowledge graph corresponding to the data set; establishing a GCN drug pair interaction prediction model, andlearning feature information of drugs contained in the drug pair and neighborhoods of the drugs; inputting the drug pair data samples of the training set into the GCN drug pair interaction predictionmodel, and training the GCN drug pair interaction prediction model; optimizing a loss function of a training result, and then sending the training result to the GCN drug pair interaction prediction model for training; conducting iterative computation to complete the training of the GCN drug pair interaction prediction model; inputting the drug pair data samples in the test set into the GCN drug pair interaction prediction model to obtain a test result; and analyzing the test result to obtain a prediction result. The knowledge graph-based graph convolution drug pair interaction prediction method and system provided by the invention are high in accuracy and short in training time.

The present invention provides a preparation method of a monascus fermentation traditional Chinese medicine health wine with a characteristic of no color fading. The preparation method is characterized by comprising: a, preparing a seed bacterial liquid for traditional Chinese medicine fermentation, red dates for traditional Chinese medicine fermentation, and a traditional Chinese medicine extraction drug wine for traditional Chinese medicine fermentation; and b, preparing the traditional Chinese medicine fermentation drug wine. The method of the present invention has the following beneficial effects that: the traditional Chinese medicine extraction rate is increased, the drug wine use effect is increased, the drug consumption is reduced, the monascus active component synthesis is increased, the enzyme activity is improved, the obtained wine has characteristics of pleasant color, no color fading, mellow alcohol taste, rich taste, pleasant aroma, no bitter taste, disease prevention, enjoyment feeling, red and bright color, clarified and transparent wine liquid, aroma, mellow taste, concurrent color, aroma and taste provision, perfect health, color and taste integration, health effect, and drinking interest enjoying, the method has characteristics of low equipment investment requirement and low cost, and is suitable for large-scale industrial production, and the obtained product does not contain any chemical additive components and is green and natural.

An abuse deterrent and misuse deterrent transdermal patch comprising aversive agents incorporated in the backing layer of the patch. The aversive agents can exhibit biphasic or sustained kinetics of release with an immediate portion released rapidly and an extended portion released in a prolonged manner when exposed to a dissolution medium. The prolonged aversive agent release provides deterrence against extraction of drug from fresh and used patches and serves to prevent accidental misuse of used patches by children. The abuse deterrent and misuse deterrent patch systems can be used for transdermal delivery of therapeutically active agents and particularly those drugs that are highly prone to abuse such as opiate and opioid analgesics and stimulants.

The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.

The invention discloses a system for predicting drug target affinity based on a graph convolutional neural network, and belongs to the technical field of drug relocation. The system comprises three channels which are used for respectively extracting a feature vector of two-dimensional representation of a drug, a feature vector of a context association relationship of a drug SMILES expression and a feature vector of a context association relationship of a protein sequence, then splicing the three feature vectors together, and inputting the spliced three feature vectors into a full-connection neural network, and obtaining a predicted value of the drug target affinity. The input of the model is the two-dimensional representation of the drug, the SMILES expression of the drug and the protein sequence, and finally obtaining the affinity prediction value of the drug and the target.

An apparatus (100) for extracting bottles (F) from a tray (V), arranged with the mouths facing downwards in the tray (V), comprises: an advancement line (L), for stopping the trays at a rest station (S); a handling organ (M); a pickup and transfer station (1) of the bottles (F). The pickup and transfer station 1 comprises: a suction plate (3), with suction seats (31) for receiving and retaining the bottles (F) internally thereof; a frame (10) having a housing (11) for receiving, by form coupling, the suction plate (3) and releasable coupling means (19) for releasably retaining the suction plate (3) in the housing (11). The frame (10) is activatable in rotation about a first rotation axis (R1) in order to be positionable in a first operating position (P1), in proximity of the rest station (S), and in a second operating position (P2) in proximity of the handling organ (M). Gripping and moving means (40) are included, in order to pick up and move the suction plate (3) so as to position the suction plate (3) above the tray (V) so that the bottles (F) are received in the seats (31) of the suction plate (3), and to raise the suction plate (3). with the bottles (F) retained by suction inthe seats (31), and then position the suction plate (3) at the housing (11) of the frame (10) positioned in the first operating position (P1). The frame (10) is thus activatable in rotation about therotation axis (R1) in order to be positioned in the second operating position (P2), so that the bottles (F) are arranged with the relative mouths facing upwards and the handling organ (M) can pick upthe bottles (F).

The invention relates to a traditional Chinese medicine preparation for treating rheumatism, which is prepared from the following pharmaceutical products: monkshood, ligusticus wallichii franchet, radix paeoniae rubra, cassia twig, ephedra, asarum, notopterygium root, radix angelicae pubescentis, rhizoma cibotii, garden balsam stem, variegated coralbean bark, pepper stem, herb of common forkstamenflower, rhizoma atractylodis, semen coicis, cortex periplocae and liquorice. The preparation method of the traditional Chinese medicine preparation for treating rheumatism comprises the steps of: extracting pharmaceutical volatile oil from the pharmaceutical products except monkshood, dipping the monkshood in water for one hour, then decocting for three hours, adding the residual dregs of the pharmaceutical products subjected to pharmaceutical volatile oil extraction and residual medicine in the monkshood to decoct twice, filtering, standing the filtrate, extracting supernatant for concentrating to be thick paste, and adding the pharmaceutical volatile oil to prepare the preparation, wherein all of the pharmaceutical products can be extracted to be thick paste for preparing various formulations. The preparation method includes a quality control method. The invention effectively removes aconitine in the monkshood and reserves active ingredients in the monkshood by adopting a particularpreparation process. In the invention, the traditional Chinese medicine preparation has definite curative effect, high safety and better curative effect on all kinds of rheumatism, treats both principal and secondary aspect of the disease, and is prepared from pure traditional Chinese medicines so as to be convenient, safe and reliable to use.