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Extraction of pharmaceutically active components from plant materials

a technology of plant materials and active components, which is applied in the direction of solvent extraction, plant/algae/fungi/lichens ingredients, separation processes, etc., to achieve the effect of increasing the selectivity of the extraction process and improving the stability of the final bds

Inactive Publication Date: 2020-10-01
GW PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text discusses the benefits of using carbon dioxide as a solvent for extracting cannabinoids. Carbon dioxide is readily available, cost-effective, and can be recycled. It is also eco-friendly as any losses of carbon dioxide are neutral. The text also mentions that liquid formulations are preferred, specifically a formulation containing cannabinoids, ethanol, propylene glycol, and optionally flavouring like peppermint oil. This formulation can be sprayed onto the buccal or sublingual mucosae for efficient absorption of the cannabinoids. Overall, the patent text highlights the technical advantages of using carbon dioxide in extracting cannabinoids.

Problems solved by technology

Furthermore, CO2 extraction is a conservative method of preparation and quite fragile molecules can be extracted with precision.

Method used

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  • Extraction of pharmaceutically active components from plant materials
  • Extraction of pharmaceutically active components from plant materials
  • Extraction of pharmaceutically active components from plant materials

Examples

Experimental program
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example 2-investigation

of the Stabilisation of Botanical Drug Substance (BDS) by Partial Purification Using Activated Charcoal

[0191]Results from stability studies on THC formulations indicate that THC in the form of BDS is unstable even at storage temperatures as low as 5° C. This contrasts with the behaviour of the purified THC (Dronabinol USP) in Marinol soft gel capsules, for which a shelf life of 2 years at cool ambient temperature is accepted. It should also be noted that the shelf life of THC standard solutions in methanol supplied by Sigma-Aldrich is claimed to be 4 years when stored refrigerated and protected from light.

[0192]This apparent discrepancy between the stability of BDS (THC) and purified THC prompted speculation that some component of BDS was destabilising the principal cannabinoid.

[0193]A solution to this problem would be to purify the BDS (THC) to yield high purity, preferably crystalline cannabinoid. However, the additional processing costs incurred on transforming BDS to pure cannab...

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Abstract

The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 467,387, filed Mar. 23, 2017, which is a continuation of U.S. patent application Ser. No. 12 / 049,588, filed Mar. 17, 2008, which is a divisional of U.S. patent application Ser. No. 10 / 218,972, filed Aug. 14, 2002, now U.S. Pat. No. 7,344,736, the entire contents of each of which are incorporated herein by reference in their entireties.FIELD OF THE INVENTION[0002]The present invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis. BACKGROUND OF THE INVENTION[0003]In PCT / GB02 / 00620 the applicant discloses a method of preparing a herbal drug extract (botanical dru...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/352B01D11/02
CPCY02A50/30A61K36/185A61K31/352B01D11/0203
Inventor WHITTLE, BRIAN ANTHONYHILL, COLIN A.FLOCKHART, IAN R.DOWNS, DAVID VICTORGIBSON, PETERWHEATLEY, GARY WILLIAM
Owner GW PHARMA LTD
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