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Preparation method of four-season common cold capsules

A capsule and steam distillation technology, applied in the field of traditional Chinese medicine, can solve the problems of incomplete extraction of active ingredients, low bioavailability, slow disintegration speed and the like

Inactive Publication Date: 2012-02-29
哈药集团三精千鹤制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The extraction process used in Siji Ganmao Capsules is mainly traditional alcohol extraction and concentration, and there are many deficiencies such as incomplete extraction of active ingredients, low product content, low bioavailability, and slow disintegration speed.

Method used

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  • Preparation method of four-season common cold capsules
  • Preparation method of four-season common cold capsules
  • Preparation method of four-season common cold capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Take 250g of perilla leaves, 167g of tangerine peel, 125g of Nepeta, extract the volatile oil a by steam distillation, set aside, and collect the distilled aqueous solution b in another device; Rhizoma Cyperi 167g, Fangfeng 125g, the compound enzyme is a mixture of cellulase and pectinase, the ratio is 2:1, 8 times the amount of medicinal materials, 50% ethanol enzymolysis, enzymolysis temperature is 30°C, pH value is 3, enzyme dosage 100 / g, and the enzymolysis time is 1h, to obtain clear paste c; the aqueous solution b is mixed with clear paste c, concentrated, dried, and the extract is crushed into a particle size of 47-15 microns (completely passing through a 300-mesh sieve) with a jet mill. For ultrafine powder, spray a dissolved in ethanol, add appropriate amount of magnesium stearate, mix well and pack into capsules.

specific Embodiment 2

[0058] Take 250g of perilla leaves, 167g of tangerine peel, 125g of Nepeta, extract the volatile oil a by steam distillation, set aside, and collect the distilled aqueous solution b in another device; Rhizoma Cyperi 167g, Fangfeng 125g, the compound enzyme is a mixture of cellulase and pectinase, the ratio is 4:1, 8 times the amount of medicinal materials, 70% ethanol enzymolysis, enzymolysis temperature is 40°C, pH value is 4, enzyme dosage 300U / g, the enzymolysis time is 2h, and the clear paste c is obtained; the aqueous solution b is mixed with the clear paste c, concentrated, dried, and the extract is crushed into a particle size of 47-15 microns (completely passing through a 300 mesh sieve) with a jet mill. For ultrafine powder, spray a dissolved in ethanol, add appropriate amount of magnesium stearate, mix well and pack into capsules.

Embodiment 3

[0060] Take 250g of perilla leaves, 167g of tangerine peel, 125g of Nepeta, extract the volatile oil a by steam distillation, set aside, and collect the distilled aqueous solution b in another device; Rhizoma Cyperi 167g, Fangfeng 125g, the compound enzyme is a mixture of cellulase and pectinase, the ratio is 2:1, 8 times the amount of medicinal materials, 60% ethanol enzymolysis, enzymolysis temperature is 40°C, pH value is 3.0, enzyme dosage 200U / g, enzymatic hydrolysis time is 1.5h, to obtain clear paste c; aqueous solution b is mixed with clear paste c, concentrated, dried, and the extract is crushed into a particle size of 47-15 microns with a jet mill (completely passed through a 300-mesh sieve) The superfine powder, spray into a dissolved in ethanol, add an appropriate amount of magnesium stearate, mix well and pack into capsules.

[0061] The positive effect of the present invention is that the content of forsythin in Sijimaomao Capsules can reach 113.06 μg / capsule by ...

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Abstract

The invention relates to a preparation method of four-season common cold capsules. According to the invention, ranges of factors suitable for enzymolysis are summarized through single factor tests; and an optimal technology for extracting active components of the four-season common cold capsules is optimized through orthogonal tests. According to the invention, an extract is crushed into micro-powder with grain sizes smaller than 50 micrometers by using a jet mill; the micro-powder is added to a pharmaceutically acceptable excipient, and the mixture is well mixed; and the mixture is filled into capsules. According to the invention, active components of the medicine are extracted by using a composite enzymolysis method. The method is advantaged in that: the active components are fully extracted; the bioavailability of the active components is high; the disintegration speed of the active components is high, the absorption of the active components is good; the content of the active components is high; the quality of the active components is stable, and the reproducibility of the active components is good.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine, in particular, to a preparation method of Sijimao capsule for treating Sijifengcold and common cold, and more specifically, through single factor test and orthogonal test, the optimum compound enzyme method for extracting forsythin is optimized. Good workmanship. Background technique [0002] Sijimao Capsules, clearing away heat and relieving the surface, are used for symptoms such as fever, headache, runny nose, dry cough, sore throat, nausea and anorexia caused by Sijifengmao. Among them, forsythin is the main active ingredient in Sijimao Capsules. To evaluate the quality of Sijimao Capsules. [0003] The extraction process used in Siji Ganmao Capsules is mainly traditional alcohol extraction and concentration, and there are many deficiencies such as incomplete extraction of active ingredients, low product content, low bioavailability, and slow disintegration speed. Conten...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P1/08A61P1/14A61P11/02A61P11/04A61P11/14A61P25/04A61P29/00
Inventor 孙开敬武凤梅郑玉梅费建军朱文军刘广和李尚晏尹逊录赵修森
Owner 哈药集团三精千鹤制药有限公司
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