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Medicine for spasmolysis and relieving pain and preparation method

An analgesic and antispasmodic technology, applied in the field of combined medicines, can solve the problems of difficulty in mass preparation and the like

Inactive Publication Date: 2005-02-16
JILIN TIANYAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For this reason, glycyrrhetinic acid can be used as the antispasmodic component in the combination medicine. The above experiments also prove that paeoniflorin and paeoniflorin metabolites are effective ingredients for analgesia and sedation. preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0073] 1. Preparation of glycyrrhetinic acid: Add water to the licorice slices and boil for 3 times, respectively for 3 hours, 2 hours, and 1 hour, filter and combine the liquid medicine, add concentrated sulfuric acid until no precipitation occurs, let it stand, filter out the precipitate, and wash with water , dried under reduced pressure to obtain crude glycyrrhizic acid. Reflux extraction with acetone for 3 times to obtain acetone extract, put it at room temperature, add KOH alcohol solution with a concentration of 20% under stirring until it is weakly alkaline (PH8-9), leave it to stand, crystals precipitate, and filter out the crystals (tripotassium glycyrrhizinate Salt), dry under reduced pressure, add glacial acetic acid to melt at 60°C, put it at room temperature, precipitate crystals, filter to obtain monopotassium glycyrrhizic acid, add dilute sulfuric acid with a concentration of 5%, boil and heat for 10 hours, filter with suction, wash with water until neutral , a...

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Abstract

The invention is a spasmolysis and pain easing medicine and its manufacturing method, it extracts medicine active substance enoxolone glycyrrhetinic acid from liquorice and extracts active substance paeoniflorin from peony according to the curing mechanism of peony and liquorice. And then are blended with medicine carrier and / or excepient, thus the current medicine with the same curative effect to peony and liquorice soup can be produced; it has a small volume, convenient, and has no toxin and side effects.

Description

Technical field: [0001] The invention relates to a combination medicine, in particular to a combination medicine for treating abdominal smooth muscle spasms and headaches and a preparation method thereof. Background technique: [0002] Shaoyao Gancao Decoction is a well-known famous prescription in the field of traditional Chinese medicine in China. It is mainly used in the treatment of abdominal smooth muscle spasm and pain such as menstrual pain, uterine cramps and stomach pain. [0003] Although Shaoyao Gancao Decoction has unique curative effects, its dosage form is still a traditional decoction. Obviously, it cannot be produced industrially, but it is boiled by the users themselves. And because the whole material is used as medicine, the active ingredients of the medicine are not clear, and there are no curative or even harmful impurities mixed in it. Therefore, pharmacological analysis of Chinese herbal medicines, isolation of medicinal active substances, and large-s...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/20A61K9/48A61K31/7048A61P1/06A61P29/00
Inventor 王本祥张连珠陈声武李海日
Owner JILIN TIANYAO SCI & TECH
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