68 results about "Extracorporeal membrane oxygenation" patented technology

A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.

A customizable and intuitive user interface for medical systems and devices, such as cardiopulmonary bypass systems, perfusion systems, extracorporeal circulation apparatuses, and heart-lung machines, is provided, which allows for ease of access to critical patient data to facilitate blood perfusion and to monitor and regulate various physiological parameters of a patient and an extracorporeal blood flow circuit during surgical procedures, such as cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO).

The invention belongs to the field of medical apparatuses, and relates to an artificial heart assisting device for treating heart failure caused by acute cardiogenic shock, in particular to an in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump. The in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump adopts a non-bearing magnetic fluid levitation technology to substitute mechanical bearing driving of the conventional centrifugal blood pump, an impeller rotor is suspended in a magnetic field without any mechanical contact, and the position and the speed of the impeller rotor are precisely regulated by a digital signal processor system, so that damage to blood cells and visible components (platelets, blood coagulation factors and the like) of blood is reduced to the most extent; meanwhile, by a heparin coating technology applicable to the inner wall of the blood pump and the surface of the impeller rotor, coagulation and thrombosis as well as use of an anticoagulant medicine in the assisting process are further reduced, so that complications of hemorrhage of a patient during a surgery are reduced. The in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump has the characteristics of being simple in structure, reliable in operation, convenient to maintain, stepless in speed regulation and the like, can be used for treating the heart failure caused by acute cardiogenic shock triggered by a variety of reasons, and in combination with an oxygenator, can also be used for assisting circulation and blood oxygenation during extracorporeal membrane oxygenation (ECMO) treatment.

A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.

Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.

A system, method, and apparatus for a patient simulator that interacts with a diagnostic or therapeutic medical device. The system includes a computing device coupled to a patient module. The patient module includes hydraulic equipment that simulates a baseline fluid interconnection with a therapeutic device. The computing device manages physical and virtual data, provides algorithmic calculations for simulating hypothetical patient vital signs, long-term clinical course, and simulates related fluid properties. The simulation system automatically executes a step-wise clinical scenario, specified in a spreadsheet format of patient conditions and equipment scenarios, that also includes audio / visual stimuli of operating room and diagnostic clinic environments, along with data recording capabilities. The therapeutic device can be a heart lung machine (HLM), an extracorporeal membrane oxygenation (ECMO) machine, an emergency cardiac life support (ECLS) device, a ventricular assist device (VAD), a dialysis machines, a hyperthermic intraperitoneal chemotherapy (HIPEC) machine, and an aortic balloon pump.

A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

Devices and methods for perfusing a patient's vasculature are provided. The device preferably includes a cannula with a port and a retractable sheath disposed over the port of the cannula. When the cannula is positioned within the patient's vasculature, the retractable sheath may be retracted to expose the port to divert blood flow towards another portion of the patient's vasculature, for example, to prevent ischemia of the patient's lower extremities. The device may be used during heart surgery, percutaneous heart or circulatory procedures, or other cardiac interventional procedures and may be used in conjunction with another device such as an extracorporeal membrane oxygenation (“ECMO”) machine.

The present invention is a hemostatic plug for use with Extracorporeal Membrane Oxygenation (ECMO) cannulas that allow quick access to the blood vessel as well as maintaining a sterile environment to resume ECMO, if needed. It is designed to be a universal fit for use with adult ECMO circuits. The plug consists of a hemostatic membrane, a collection chamber and a cap. The membrane is designed to allow catheter delivery of up to a 19 French diameter through the ECMO cannula. The collection chamber allows the distribution of blood pressure over a broader surface, which allows additional hemostasis in addition to the membranes. The plug is then further reinforced with a cap that provides additional hemostasis, but when removed, allows hemostatic access into the blood vessel via the ECMO cannula.

A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drainage tube. The first and second drainage tubes are fluidly coupled to a connector. A blood pump having a pump inlet is configured for fluidly connecting with the connector, while an oxygenator having an oxygenator inlet is configured for fluidly connecting with a pump outlet. An infusion cannula is configured for fluidly connecting with an oxygenator outlet for infusing oxygenated blood into a patient's bloodstream.

The present invention provides a method, system, and apparatus that can substantially reduce the recirculation of venovenous extracorporeal membrane oxygenation (VV ECMO) associated with the two-site, single-lumen cannulation approach. Actively-controlled flow regulators comprising balloon, occluder and reservoir can be individually or collectively equipped on the drainage and / or infusion cannulas to accomplish the goal of maximizing VV ECMO support efficacy. Three specific embodiments are introduced to illustrate the practical enforcement of the proposed blood flow control in reference to the heart rhythm, aiming at achieving the maximal reduction of oxygenated blood flow recirculating back to the VV ECMO circuit.

The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, asa respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housingstructure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.

The invention provides a volute pump head for an artificial heart. The volute pump head comprises a volute, wherein the volute comprises a blood inlet and a blood outlet; the volute is internally provided with a fixing shaft; the fixing shaft is sleeved by a magnetic body; a conical impeller of an opening structure is mounted on the outer side of the magnetic body; when the magnetic body is rotated, the conical impeller is driven to rotate; a first gap is formed between the fixing shaft and the magnetic body; and when the conical impeller is driven to rotate by the magnetic body, a part of blood flows upwards through the first gap, and the conical impeller is suspended in the blood. The invention further provides an artificial heart pump and (extracorporeal membrane oxygenation) equipment.According to the pump head for the artificial heart provided by the invention, due to height and inclination designing of a first blade and a second blade, sufficient washing can be benefited, and thrombus and blood cell damage can be reduced; and due to designing of the conical impeller and the fixing shaft in the volute, heat can be effectively reduced, thrombosis can be reduced, and blood celldamage can be effectively avoided.

The invention discloses an oxygenator fixing device and a modular ECMO (Extracorporeal Membrane Oxygenation) frame vehicle using the same. The modular ECMO frame vehicle comprises a base part, a column part arranged on the base part and a lamination board part detachably arranged on the column part, wherein one side of the column part is provided with a first oxygenator fixing device body, the other side of the column part is provided with a second oxygenator fixing device body, the first oxygenator fixing device body comprises a first support and a positioning base, the first support comprises a positioning part and a movable arm assembly which are connected with each other, and the movable arm assembly can stretch out and draw back. The positioning base comprises a base body and a positioning disc arranged on the base body, the base body is detachably connected to the movable arm assembly, and a plurality of positioning bodies are arranged in the circumferential direction of the positioning disc. According to the oxygenator fixing device and the modular ECMO frame vehicle using the same, all components and accessories of ECMO are integrated, an ECMO transferring system is formed,transferring can be rapidly conducted, and the transferring device is simple in structural design, low in production cost and suitable for mass production, and can effectively improve the working efficiency of doctors.

The invention discloses an intelligent ward-type ambulance for ECMO (extracorporeal membrane oxygenation) emergency treatment. The intelligent ward-type ambulance comprises an ambulance body and a compartment, wherein the ambulance body is fixed to the bottom of the compartment and used for providing power and electric power for the compartment. The intelligent ward-type ambulance is characterizedin that emergency treatment equipment for on-site emergency treatment of critical patients is mounted inside the compartment and combined with a vehicular ECMO technology to finish the emergency treatment process of the critical patients. The emergency treatment equipment is arranged inside the ambulance body and comprises a cardio-pulmonary resuscitator, an electrocardiogram device, a respirator, an infusion and injection pump and a defibrillator, pulse current acts on a heart to implement electric-shock treatment and eliminate heart disorder, so that a heart restores sinus rhythm, the emergency treatment equipment is used in the emergency treatment process of the patients, an aspirator is used for adsorbing foreign matters in the surgical process, smoothness of the emergency treatment process is facilitated, so that the emergency treatment equipment can be combined with the vehicular ECMO technology in the emergency treatment process, the life of the critical patients is timely supported and rescued, and the use range of the ambulance is widened.

The invention discloses a tubular shaft type centrifugal oxygenation blood pump. A tubular shaft type centrifugal oxygenation blood pump body is taken as a basic structure, a power unit driving liquid to flow of the blood pump is a T-shaped tubular shaft capable of rotating at high speed, blood flows into a pump shell via the tubular shaft and gains kinetic energy on a side tube portion of the tubular shaft under the action of centrifugal force, and back-flow preventing buffer portions are arranged at tail end outlets of a side tube of the tubular shaft of the blood pump. On the basis of above structure, oxygenation slices namely oxygenation portions are continuously connected on every back-flow preventing buffer portion of the blood pump, and the oxygenation blood pump is formed by additionally arranging an air exchange system on the upper portion of the pump shell. The oxygenation blood pump has a blood driving function, also has a blood and air exchanging function, and does not require an additional oxygenator and an artificial heart-lung machine when being used for extracorporeal circulation, extracorporeal membrane oxygenation.

The invention relates to the technical field of in-vitro testing of medical instruments, in particular to a simulation cycle test system for ECMO (extracorporeal membrane oxygenation) and application of the simulation cycle test system. The invention provides the simulation cycle test system for ECMO. The simulation cycle test system comprises a pulmonary circulation simulation module, a flexible heart module, a systemic circulation simulation module, an ECMO detection module and a control detection module. The pulmonary circulation simulation module, the flexible heart module and the systemic circulation simulation module are used for simulating hemodynamic states of a human body under healthy and different pathological conditions. The control detection module is used for collecting data such as blood pressure, blood flow and oxyhemoglobin saturation and the like of each point in the test system, controlling the opening amplitude of each valve in the test system and simulating various cardiovascular and valvular diseases. A standardized ECMO testing environment is provided, a unified testing standard is provided for blood testing of ECMO and other interventional medical instruments, and meanwhile an effective basis is provided for ECMO clinical use risk assessment of patients with various valvular and cardiovascular diseases.

The invention discloses a multi-functional in-vitro life support and treatment system integrated device. The device comprises a centrifugal pump, an extracorporeal membrane oxygenation device, a plasma separator, a blood filtration column and a bilirubin adsorption column. The device can enable simultaneous clinical support and treatment of multiple organ functions to be possible by integrating the support and the treatment of the multiple organ functions into a whole; the device is simple to operate and convenient to carry, and can provide possibility for the support and the treatment of the multiple organ function of an out-of-hospital critically ill patient and provide a safe and effective measure for the out-of-hospital patient; the device can avoid multiple arterial / venous catheterization, various complications caused by the multiple catheterization and reduce the side effects of the support and the treatment of the multiple organ functions to the greatest extent; and the device is strong in compatibility and becomes a system which can be compatible with cardiopulmonary support, renal replacement therapy, liver function support, artificial enteral nutrition, immunoregulation and treatment and other various support and treatment means.

The invention discloses a long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and a preparation method of the long-term anti-freezing antibacterial coating. The method comprises the following steps: (1) mixing an anti-freezing functional monomer, an antibacterial functional monomer and a film formation agent, and performing a reaction in a mode of free radical polymerization for 10-15 hours at 60-80 DEG C so as to obtain an anti-freezing antibacterial polymer; and (2) mixing the anti-freezing antibacterial polymer with a solvent, so as to obtainthe long-term anti-freezing antibacterial coating. The invention designs the coating with long-term anti-freezing and antibacterial functions simultaneously, and antifouling and sterilization functions can be well combined. With the combination of two functions, an effect of reducing risks of bacterium infection for a long time can be achieved. By reasonably selecting and controlling introductionof antibacterial functional components, the anti-freezing function of the coating can be well maintained.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit, such as veno-venous extracorporeal membrane oxygenation, includes determining (i) a first arterial carbon dioxide content or surrogate and (ii) a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; establishing a second removal rate of carbon dioxide from the blood in the oxygenator in the extracorporeal blood oxygenation circuit; determining (i) a second arterial carbon dioxide content or surrogate and (ii) a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood; and calculating a cardiac output of the patient corresponding to a blood flow rate through the extracorporeal blood oxygenation circuit, the first arterial carbon dioxide content or surrogate, the first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; the second arterial carbon dioxide content or surrogate and the second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood.

An integrated perfusion apparatus or device for use in e.g. extracorporeal membrane oxygenation, cardiopulmonary bypass, or isolated organ or limb perfusion, comprises a blood pump for circulating blood through the device; a blood oxygenator for oxygenating blood, and at least one heat control unit capable of controlling and / or regulating blood temperature within the device, wherein the at least one heat control unit comprises at least one solid state heating and / or cooling source, such as at least one Peltier device. The invention also relates to a method of performing perfusion on a patient, limb or organ, comprising using the perfusion device.

A customizable and intuitive user interface for medical systems and devices, such as cardiopulmonary bypass systems, perfusion systems, extracorporeal circulation apparatuses, and heart-lung machines,is provided, which allows for ease of access to critical patient data to facilitate blood perfusion and to monitor and regulate various physiological parameters of a patient and an extracorporeal blood flow circuit during surgical procedures, such as cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO).

The invention belongs to the field of ECMO equipment control, provides an ECMO equipment control system with an expert knowledge base, and a method thereof, and solves the problems that delay possiblyexists in ECMO equipment adjustment and errors exist in manual adjustment. By means of the ECMO equipment control system with the expert knowledge base, and the method thereof, rule knowledge in theexpert knowledge base is utilized to infer a corresponding adjustment scheme; and timely control of a blood pump, an air-oxygen mixer and an injection pump and stable control of ECMO equipment are realized. The ECMO equipment control system with the expert knowledge base comprises a data acquisition part and a control part; the control part comprises an expert knowledge base, an inference engine and a control interface; ECMO equipment related regulation rule knowledge is stored in the expert knowledge base; the inference engine is used for receiving the related data transmitted by the real-time data acquisition part, calling adjustment rule knowledge in the expert knowledge base, and giving a corresponding real-time adjustment scheme; and the control interface is used for controlling the ECMO equipment in real time according to the real-time adjustment scheme.

A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.

The embodiment of the application relates to an extracorporeal membrane oxygenation device. The extracorporeal membrane oxygenation device comprises an artificial heart-lung unit, a control unit, a display unit, a first power supply unit and a frame structure; the frame structure includes a first frame structure and a second frame structure; a preset angle is formed between the first frame structure and the second frame structure; the control unit, the display unit and the first power supply unit are arranged on the second frame structure; the artificial heart-lung unit is arranged in a spaceformed between the first frame structure and the second frame structure; the artificial heart-lung unit and the display unit are both connected with the control unit; and the artificial heart-lung unit, the display unit and the control unit are all connected with the first power supply unit. The device disclosed by the embodiment of the invention has relatively light overall weight and is convenient to carry and use.

The invention discloses a multifunctional ECMO circulating pipeline and a method for performing extracorporeal membrane oxygenation by utilizing the multifunctional ECMO circulating pipeline. The ECMO circulating pipeline comprises an arterial circulating pipeline, a venous circulating pipeline, a blood purification inlet catheter and a blood purification transfusing catheter, wherein blood oxygen sensors are arranged on the arterial circulating pipeline and the venous circulating pipeline, and the blood oxygen sensors are connected with a blood gas detecting device; one-way valves are separately arranged at the ends, near the circulating pipeline, of the blood purification inlet catheter and the blood purification transfusing catheter. According to the ECMO circulating pipeline disclosed by the invention, the oxygen partial pressure of blood can be monitored in real time before and after blood oxygenation, the difficult problem that during an ECMO treatment period, blood collecting on two end pipelines is difficult, and the spraying probability of blood or a flushing fluid is high, can be solved, the oxygen partial pressure of the blood is detected in an nondestructive manner, and patients do not need puncture of major vascular pipelines twice; the blood oxygenation and the hemodialysis can be simultaneously realized by utilizing the ECMO pipeline, so that the pain of people can be reduced, and probable massive haemorrhage and infection can be effectively reduced.

The invention provides extracorporeal membrane oxygenation equipment of a medical first-aid technology. The equipment comprises a blood pump, an oxygenator, a variable-temperature water tank and a control main machine, the inlet end of the blood pump is connected to a blood vessel cannula, an outlet end of the blood pump is connected to a blood inlet of the oxygenator, and a blood inlet of the variable-temperature water tank is connected to a blood outlet of the oxygenator. The equipment also comprises: a thrombus treatment device, wherein a blood inlet of the thrombus treatment device is connected to a blood outlet of the variable-temperature water tank, and the thrombus treatment device is electrically connected to the control main machine; and a fixing device which is used for fixing apipeline of the oxygenation equipment. The variable-temperature water tank is used for adjusting the blood temperature to avoid blood coagulation; the thrombus treatment device is used for treating thrombus, and avoiding blood vessel blockage caused by thrombus re-infusion into blood vessels; and the arranged fixing device is used for fixing a pipeline of the oxygenation equipment, and overcomingthe defect that loosening is likely to happen when only adhesion (such as adhesive tape adhesion) is adopted.