The invention discloses a material with a biological anti-
pollution function and a preparation method and application thereof, and relates to the technical field of
biological materials. The material with the biological anti-
pollution function comprises a base material, a polyaminophenol
coating and a
hyaluronic acid layer, Wherein the polyaminophenol
coating is obtained by reaction of phenolic molecules and
polyamine molecules. The preparation method comprises the following steps: forming the polyaminophenol
adhesive coating on the base material by utilizing a
phenol-amine chemical coating technology, and then covalently
grafting hyaluronic acid by utilizing amino groups on the polyaminophenol
adhesive coating to form a
hyaluronic acid coating. After the coating is in contact with an
aqueous solution, a hydration layer is formed on the surface to form a super-hydrophilic surface, so that adhesion, migration and proliferation of components, endothelial cells,
smooth muscle cells, inflammatory cells and the like in blood and a coating modified material are effectively inhibited, and therefore, the material with the biological anti-
pollution function can be prepared and formed as follows: a
vena cava filter, an
artificial heart inner wall anticoagulation surface, an
artificial heart-
lung machine anticoagulation surface and the like.