510 results about "Epileptic convulsions" patented technology

Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are pharmaceutical compositions and kits for the treatment or prevention of chronic pain or convulsion.

The present invention provides a helicid powder injection and its preparation method. Every powder injection contains 25-600 mg of helicid, and the rest is medicinal auxiliary material for injection. It has good stability, can be stored for 3 years at normal temperature, its irritation is small, and its injection site has no clear change or light hyperemia, and its sedation effect is good, and its convulsion-resisting action is strong, it can obviously reduce coriamyrtin convulsion incidence rate, prolong generative latent period, reduce frequency of attack and shorten time and process of attack. The tests show that said helicid powder injection has the strong action of stopping pain and relieving inflammation.

The present invention relates to an improved extract of Scutellaria lateriflora, a method of preparing the same, and a pharmaceutical composition prepared from the present extract suitable for treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals.The invention also relates to an improved method of treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals by administering the improved extract of Scutellaria lateriflora.

The invention relates to a novel piperazinoamide compound, a preparation method thereof, and application thereof in treating neurodegenerative disease, mental disease, epilepsy, convulsion, apoplexy, and the like. The structure of the piperazinoamide compound is shown as formula I. The in vitro tests verify that the piperazinoamide compound has an effect of inhibiting cells BV2 from secreting IL-1beta effectively, and has high safety. The formula I is shown in the description.

A compound represented by the formula (I):or a pharmaceutically acceptable salt thereof, wherein:R1 represents a branched lower alkyl group having from 3 to 9 carbon atoms or the like;R2 represents a 6-membered heteroaryl group having 1 or 2 nitrogen atoms or the like;R3 represents a hydrogen atom, an alkanoylamino group or the like;R4 represents a hydrogen atom, a lower alkyl group or the like;X1 represents an oxygen atom or a sulfur atom;X2 represents an oxygen atom or a single bond; andm indicates an integer of from 0 to 4.This compound has a metabotropic glutamate receptor 1 inhibitory effect, and therefore is useful for the treatment of a brain disorder such as convulsion, acute pain, inflammatory pain, chronic pain, cerebral infraction or transient cerebral ischemic attack, a mental dysfunction such as schizophrenia, and a disease such as anxiety and drug addition.

The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

The invention discloses fructus akebiae healthy tea which is prepared from fructus akebiae,narrow-leaved oleaster fruit, marigold, green alectoria filament, rhodobryum giganteum, and Siberian nitrari in a certain weight proportion. The healthy tea has the purposes of dispersing the liver depression, promoting blood circulation to stop pain, tranquilizing and allaying excitement, relieving heart to treat eye disease, and strengthening by means of tonics. Owing to low cost, good effect, reasonable formula, easy preparation, simple preservation, being suitable for four seasons, curing diseases and protecting health, convenient drinking and good taste, the healthy tea is applicable to those who suffer from diseases such as liver and stomach pains due to disorder of qi, stomach heat and poor appetite, dyspepsia, soothing liver and tonifying kidney, strengthening spleen and stomach, invigorating spleen and stomach, body weakness, cough due to lung-heat, dizziness and blurred vision, infantile convulsion, cold and cough, neurasthenic, body emaciation, deficiency of both qi and blood, dyspepsia, abnormal menstruation, etc., on which the healthy tea performs good effects. The fructus akebiae healthy tea is an ideal healthy drink.

Disclosed herein is a transnasal anticonvulsive pharmaceutical composition comprising diazepam as an active ingredient, water, a fatty acid ester, diethylene glycol monoethyl ether, ethanol and sodium glycocholate, wherein the weight of the fatty acid ester is at least 2-fold higher than that of water and is at least 2-fold higher than that of ethanol.The anticonvulsive pharmaceutical composition for transmucosal delivery of diazepam according to the present invention includes a minimized content of water and ethanol, a fatty acid ester as a main ingredient and no use of a polar solvent, e.g. glycol, and, exhibits improved diazepam solubility and transmucosal permeability due to using a small amount of water and ethanol. The present invention also includes treatment of convulsions by transnasally administering to a patient in need thereof a therapeutically effective amount of the disclosed compositions.