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Ultramicro wall-broken gastrodia elata composition and preparation method thereof

A kind of gastrodia elata, ultra-micro technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems affecting the safety of clinical medication, increase toxicity, etc., and achieve the effect of increasing bioavailability, low toxicity, and good efficacy

Inactive Publication Date: 2014-12-10
HUNAN BUTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for drugs containing toxic ingredients, the toxicity may increase after ultrafine pulverization, which will affect the safety of clinical medication.

Method used

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  • Ultramicro wall-broken gastrodia elata composition and preparation method thereof
  • Ultramicro wall-broken gastrodia elata composition and preparation method thereof
  • Ultramicro wall-broken gastrodia elata composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Wash 10kg of high-quality, fresh and mildew-free Gastrodia elata three times with 5MPa high-pressure water to remove sediment, and then clean it at 40°C with 40KHz ultrasonic power for 30 minutes; put the cleaned Gastrodia elata in a high-pressure boiler, and steam Cook for 8 hours; then cut the obtained Gastrodia elata into 1cm slices; take another 1kg of ginger, mash and boil the juice, soak the slices of Gastrodia elata in ginger juice for 4 hours, and then steam cook for 8 hours in a pressure cooker at 120°C; then Place in an open oven at 75°C and dry for 10 hours; then use a jet mill to ultrafinely pulverize the dried Gastrodia elata slices; extract the obtained Gastrodia elata ultrafine powder with water at 60°C for 2 hours, spray dry, Finally, the Gastrodia elata ultrafine powder is mixed with ultrafinely pulverized starch, microcrystalline cellulose, sodium lauryl sulfate and magnesium stearate to prepare the preparation to obtain ultrafine Gastrodia elata decoct...

Embodiment 2

[0056] Wash 15kg of high-quality, fresh and mildew-free Gastrodia elata three times with 5MPa high-pressure water to remove sediment, and then clean it with 40KHz ultrasonic power at 40°C for 50 minutes; put the cleaned Gastrodia elata in a high-pressure boiler, and steam Cook for 6 hours; then cut the obtained Gastrodia elata into 1cm slices; take another 3kg of ginger, mash and boil the juice, soak the slices of Gastrodia elata in ginger juice for 4 hours, and then steam cook for 8 hours in a pressure cooker at 120°C; then Place in an open oven at 85°C and dry for 15 hours; then use an airflow mill to carry out ultrafine pulverization of the dried Gastrodia elata slices; finally mix Gastrodia elata ultrafine powder with ultrafinely pulverized starch, microcrystalline Alkyl sodium sulfate and magnesium stearate are mixed and prepared to obtain superfine Gastrodia elata decoction pieces.

Embodiment 3

[0058] Wash 10kg of high-quality, fresh and mildew-free Gastrodia elata three times with 5MPa high-pressure water to remove sediment, and then clean it at 40°C with 40KHz ultrasonic power for 30 minutes; put the cleaned Gastrodia elata in a high-pressure boiler, and steam Cook for 8 hours; then cut the obtained Gastrodia elata into 1cm slices; take another 1kg of ginger, mash and boil the juice, soak the slices of Gastrodia elata in ginger juice for 5 hours, and then steam cook for 8 hours in a pressure cooker at 120°C; then Place in an open oven at 85°C and dry for 15 hours; then use an airflow mill to carry out ultrafine pulverization of the dried Gastrodia elata slices; finally mix Gastrodia elata ultrafine powder with ultrafinely pulverized starch, microcrystalline Alkyl sodium sulfate and magnesium stearate are mixed and prepared to obtain superfine Gastrodia elata decoction pieces.

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Abstract

The invention discloses a preparation method of an ultramicro gastrodia elata decoction piece. The preparation method comprises selection of raw materials, cleaning of the raw materials, boiling, slicing, secondary boiling, drying, ultramicro wall breaking, obtaining of a preparation, and the like. Gastrodia elata processed by employing the processing and ultramicro fragmentation method has relatively high effective-composition dissolution rate, the bioavailability of a medicine is improved, the medicine effect is relatively good, and the toxicity is relatively low. The invention also discloses the decoction piece prepared by employing the method, and application of the decoction piece to prepare medicines for treating headache dizziness, numbness of limbs, infantile convulsion, epilepsy, twitch, tetanus and other diseases.

Description

technical field [0001] The application relates to a preparation method of an ultramicro Gastrodia elata composition, which belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Gastrodia elata Bl., also known as Chijian, Limu, Guiduyou, Shencao, Duyaozhi, Chijianzhi, Dingfengcao, Helicao, Duyao, Automatic Grass, Water Potato, Tomorrow Ma etc., are perennial herbaceous plants of Orchidaceae and Gastrodia genus, distributed in most parts of the country. Its dry tubers, also known as Gastrodia elata, are commonly used and relatively expensive traditional Chinese medicines. They are mostly used clinically for headaches, dizziness, numbness of limbs, convulsions in children, epilepsy, convulsions, and tetanus. [0003] In the field of conventional traditional Chinese medicine, gastrodia elata is generally processed by processing. The processing method recorded in "Chinese Pharmacopoeia" (the first edition in 2005) is "cleaning, moisten...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P1/08A61P25/00A61P25/08A61P21/02
Inventor 石孟
Owner HUNAN BUTIAN PHARMA
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