49 results about "Degenerative arthropathy" patented technology

The present invention relates to a medical composite biomaterial. More specifically, the present invention relates to a medical composite biomaterial including collagen and a hyaluronic acid derivative. Also, the present invention relates to a cartilage cell treating agent using the biomaterial and stem cells derived from a mammal umbilical cord. The biomaterial does not cause an immune reaction, has superior durability, and the cartilage cell treating agent comprising the biomaterial and the stem cells enables arthroscopic surgery, thereby reducing pain of the patient and effectively treat of degenerative arthritis and cartilage damage.

The present disclosure is directed to methods and compositions for treating osteoarthritis and preventing osteoarthritis, by administering a compound that modulates one or more components in the complement system. In one embodiment, a compound that inhibits a component in the complement system is administered to prevent, delay the progression of, or treat osteoarthritis. In other embodiments, compounds with specific inhibition of a component in a particular pathway in the complement system, such as the alternative, mannose binding lectin, and / or classical pathway, are administered to a subject having osteoarthritis or at risk of developing osteoarthritis.

The invention discloses a health product for keeping joint health and increasing bone density and a preparation method thereof. The health product comprises the following active components: glucosamine, chondroitin sulfate, a calcium agent, a copper agent, a manganese agent and vitamins, wherein the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture; auxiliary materials comprise an excipient, a disintegrant, a lubricant, an adhesive, a wetting agent and a coating pre-mixing agent. The health product contains vitamin D3 which can be used for supplementing mineral matters, such as calcium and the like for human bodies and promoting absorption and have treating and preventing functions for rheumatoid arthritis, degenerative arthritis and damaged joint motion. A tabletprepared by the method has the advantages of good disintegrating performance, quick dissolution and effect taking, optimal proportion of use amount of raw materials and various auxiliary materials, product stability enhancement and high absorption utilization rate.

The present disclosure relates to an animal knee joint implant that reflects an anatomical structure of an animal. More particularly, the present disclosure relates to an animal knee joint implant that reflects the anatomical structure of an animal, wherein the knee joint implant is capable of being used for diseases, which are accompanied by bone loss, damage to surrounding muscles, ligaments, and the like and are thus more complex than general knee joint diseases such as rheumatoid arthritis and degenerative arthritis, and wherein the animal knee joint implant is capable of reinforcing stability against varus and valgus as well as stability against flexion and extension, and capable of easily complementing gaps that may occur when the bones of a joint are cut.

The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.

A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and / or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein / s (BMP) and / or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and / or a cranio-facial maxillary bone, for restoring and / or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and / or dysfunction of cartilage and / or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.

The invention discloses application powder for removing toxicity and dredging collaterals. The application powder is prepared from the following raw materials in parts by weight: 15-20 parts ofkusnezoff monkshood root, 14-18 parts ofmonkshood, 12-16 parts ofrhizoma arisasmatis, 10-15 parts of asarum, 8-12 parts of Chinese blister beetle, 10-15 parts of angelica root, 12-16 parts of frankincense, 14-18 parts ofacronychia leaf, 16-22 parts of myrrh, 5-10 parts of hematoxylon, 7-13 parts of water pepper root, 10-15 parts of turmeric, 5-10 parts of cortex erythrinae, 11-17 parts of artemisia anomala, 10-15 parts ofmadder, 5-10 parts of curcuma zedoary, 10-15 parts of luffa stem, 5-10 parts of angelica pubescens, 12-16 parts of safflower, 14-18 parts of red peony root, 17-23 parts of camphor root, 10-15 parts of lindera aggregata, 5-10 parts of paniculate swallowwort root, and 10-15 parts of radix clematidis. The medicinal materials are compatible and have the effects of relaxing tendons and dredging collaterals, warming channel and expelling cold, strengthening tendons and bones, activating blood circulation to remove stasis, diminishing swelling and relieving pain, removing toxicity and stagnation, and the like, is remarkable in effect, quick in response and short in cycle of healing when used for treating rheumatic arthritis, rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperostosis, femoral head necrosis and other bone diseases, does not have toxic or side effect, prevents relapse, and is safe and reliable.

The invention relates to traditional Chinese medicine combination for treating retrogressive arthritis and preparation method thereof, belonging to pharmaceutical technique field. The traditional Chinese medicine combination is prepared by the following raw materials by weight parts: mastic, myrrh, acanthopanax bark, pubescent angelica root, radix gentianae macrophyllae, tetrandra root, cibot rhizome, variegated coralbean bark, Chinese clematis, parasite scurrula, mulberry twigs, pepper, boston ivy, camphor respectively 1-5 parts, borneol 2-5 parts, nux vomica 3-7 parts, sichuan aconite root, cinnamon, Lingxian, earthworm, pangolin, pawpaw, rhizome respectively 3-5 parts, sesame oil 5-10 parts. The preparation method is as follow: (1) crushing, (2) refining oil, (3) spreading.

The invention relates to a patch and a preparation method thereof. The patch provided by the invention mainly comprises hydrogel and a traditional Chinese medicine composition. The patch has the beneficial effects that the patch provided by the invention has the effects of activating blood and dissolving stasis, clearing damp and dispelling cold, dredging collaterals and alleviating pain as well as resolving hard lump and is applicable to people suffering from pain caused by rheumatism and rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, psoatic strain, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, femoral head necrosis and acute and chronic soft tissue loss.

The invention discloses an ankle joint fracture assisting treating device. The ankle joint fracture assisting treating device comprises a shank fixing part, a foot fixing part and an L-shaped protecting part. By means of the ankle joint fracture assisting treating device, physical agent therapy and sports therapy are combined, an operator conveniently conducts joint mobilization therapy like passive activities of pushing and pulling, the recovery effect of a dysfunctional ankle joint fracture patient can be improved, the living quality of the patient is improved, and the occurrence of traumatic arthritis or retrogressive arthritis can be effectively prevented; meanwhile, the fixing performance and the fitting performance are good, and the practicability is high; the ankle joint fracture assisting treating device is low in weight, and helps to maintain cleanliness of the part and prevent infection.

The invention relates to a traditional Chinese medicine combination for treating retrogressive arthritis and preparation method thereof, belonging to pharmaceutical technique field. The traditional Chinese medicine combination is prepared by the following raw materials by weight parts: kusnezoff mondshood, suchuan aconite root, cinnamon, Chinese clematis, earthworm, pangolin, boston ivy, camphor respectively 3-5 weight parts, bornel 3-5 weight parts, rosin 10-20 weight parts, oleum sesami 10-15 weight parts. The preparation method of the traditional Chinese medicine combination are as follow: (1) crushing: respectively crushing borneol and camphor and sieving through 80 mesh, for being standby; mixing and crushing the other raw materials except rosin and sieving the mixture through 80 mesh, for being standby; (2) oil refining: decocting oleum sesami to be water-droplet shaped when dribbling, adding rosin while stirring the oleum sesami, then adding the other medicine and finally adding borneol and camphor; (3) spreading out: slowly plunging the plaster into cold water and continuously stirring the mixture; drying the plaster in the shade to remove the water, heating plaster to dissolve on water bath, spreading out the dissolved plaster on cloth.

The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.

The present invention relates to a medical composite biomaterial. More specifically, the present invention relates to the medical composite biomaterial comprising collagen and a hyaluronic acid derivative. Also, the present invention relates to a cartilage cell treating agent using the biomaterial and stem cells derived from a mammal umbilical cord. The biomaterial does not cause an immune system reaction, has superior durability, and the cartilage cell treating agent comprising the biomaterial and the stem cells enables arthroscopic surgery, thereby reducing pain of the patient, and can effectively treat degenerative arthritis and cartilage damage.

The invention discloses an external traditional Chinese medicine bag for treating arthritis, which is characterized by comprising the following components by weight ratio: 20g of medicinal cyathula root, 15g of radix angelicae pubescentis, 20g of lycopodium clavatum, 15g of safflower carthamus, 15g of Herba Siegesbeckiae, 12g of folium artemisiae argyi and 12g of rhizoma zingiberis. Medicines of promoting blood circulation and removing obstruction in channels and relieving exterior syndrome and repelling cold are compatible with each other; each component acts on each pathological level of the arthritis to dispel the wind, eliminate dampness, activate collaterals and stop pain and integrally improve various pathological changes of the arthritis to achieve the goal of treating the degenerative arthropathy, osteoproliferation and the like of cervical vertebra joints, lumbar vertebra joints, knee joints, hip joints and the like and dispel the symptoms of pain and the like caused by the arthritis. The external traditional Chinese medicine bag has the advantages of low cost, convenience in use, high safety, small side effects, fast effect, obvious curative effect and the like.

The invention belongs to the field of medicines, and concretely relates to a medicine prescription for degenerative arthritis and osteoporosis and a tablet preparation method thereof. The medicine prescription for degenerative arthritis and osteoporosis comprises the following compositions: chondroitin sulfate, glucosamine sulfate, calcium carbonate, calcium hydrogenphosphate, vitamin C, vitamin D3 and casein phosphopeptide. The beneficial effects comprise that the prescription is capable of scientifically solving casein phosphopeptides of the old, and is free of side effect in the usage process, is suitable for long-term usage and stable in curative effect. Also, the table preparation method for the prescription possesses the advantages of high production efficiency, low production cost, stable product quality and the like.

Disclosed is a pharmaceutical composition for preventing or treating TRPV1 activity-related or inflammation-related, diseases or conditions, containing a Maillard peptide separated from well-aged traditional soy sauce as an active ingredient. The Maillard peptide in the present invention functions both as a TRPV1 agonist and a TRPV1 antagonist, and further functions as a TRPV1 activity modulator. Therefore, the Maillard peptide can be used for preventing or treating TRPV1 activity-related diseases such as pain, neurological diseases, urgent defecation, inflammatory bowel disease, respiratory diseases, urinary incontinence, overactive bladder, neurogenic / allergic / inflammatory skin diseases, skin, eye or mucosal irritation, hyperacusis, tinnitus, vestibular hypersensitivity, heart disease, etc. The Maillard peptide can further inhibit COX-2 activity, and therefore can be effectively used for preventing or treating inflammation-related diseases or conditions such as rheumatic fever, influenza, cold, throat pain, headaches, toothaches, sprains, neuralgia, synovitis, rheumatoid arthritis, degenerative arthropathies, gout, ankylosing spondylitis, psoriasis, dermatitis, etc.

The invention provides a traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine preparation formulae: 12g of notopterygium roots, 12g of radix angelicae tuhuo, 10g of carthamus tinctorius, 15g of akebiaquinata, 10g of lycopodium clavatum, 15g of rhizoma corydalis, 10g of radix angelicae, 6g of asarum, 10g of rhizoma sparganii and 10g of curcuma zedoary. A making method comprises the following steps: preparing materials; cleaning, and crushing; making medicine bags; soaking with cold water; carrying out primary decoction; carrying out secondary decoction; mixing decoctions; smashing medicine dregs; mixing, and boiling; molding the traditional Chinese medicine preparation. The traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis, which is provided by the invention, has the effects of eliminating swelling and reliving pain and activating blood and removing stasis for swelling pain and hydrarthrosis caused by orthopedic diseases such as acute gouty arthritis, acute sprain, scapulohumeral periarthritis degenerative arthritis, tenosynovitis and synovitis.

The invention relates to an agkistrodon-containing preparation for gouty arthritis treatment and belongs to the technical field of Chinese herbal medicine preparations. The preparation is prepared from three Chinese herbal medicines including agkistrodon, coix seeds and pseudobulbus cremastrae seu pleiones. The preparation is based on research and treatment principles of traditional Chinese medicine for pathogenesis of gouty arthritis and refers to scientific achievements of modern traditional Chinese medicine theories for Chinese herbal medicine treatment of gouty arthritis, and agkistrodon is adopted to dispel wind and remove obstruction in the meridians and is supplemented with the coix seeds for excreting dampness, removing arthralgia, eliminating toxic materials and removing stasis; the pseudobulbus cremastrae seu pleiones has effects of clearing away heat and toxic materials, reducing phlegm and resolving masses; the three Chinese herbal medicines are compatible, supplement each other, and has functions of dispelling wind, removing obstruction in the meridians, excreting dampness, removing arthralgia, eliminating toxic materials and removing stasis. The prescription is rigorous, accords with traditional Chinese medicine theories and new knowledge of the modern medicine for gouty arthritis and is free of toxic and side effects; the preparation has remarkable curative effects on redness and swelling of joints, heat pain, stiffness, flexion-extension inconvenience due to gouty arthritis as well as inhibition for uric acid formation and further has obvious curative effects on rheumatic fever, rheumatoid arthritis, ankylosing spondylitis and degenerative arthritis.

The invention discloses an oral liquid medicament for tonifying kidney and strengthening bone and a method for producing the same. The method comprises the following steps: adding water into barbary wolfberry fruit, astragalus, szechwon tangshen root, glossy privet fruit, Himalayan teasel root, fortune's drynaria rhizome, flowery knotweed stem, spina date seed, shinyleaf pricklyash root, Chinese angelica, radix aconite preparata and liquoric root for decoction, merging decoction, filtering the decoction, concentrating the decoction under a reduced pressure into thick paste, cooling the thick paste, adding ethanol for precipitation twice, recycling the ethanol under the reduced pressure, rationally adding distilled water, uniformly stirring the paste for cold storage, filtering the stirred paste, rationally adding gooey and an aseptic for boiling, and filtering, encapsulating and sterilizing the solution. The oral liquid medicament has relatively better healing effect on fracture in convalescence, soft tissue injury, patients in recovery after operations, lumbar and leg pain, bone loss, degenerative arthritis and liver and kidney deficiency type lumbar intervertebral disc protrusion, satisfactory clinical effect, good taste and convenient administration, does not cause cutaneous anaphylaxis and other untoward reactions, and has the characteristics of simple production process, stable product quality and low cost.

This invention relates to novel ss-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and / or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.

This invention relates to novel β-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and / or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.

The invention provides a preparation method of a hydrogel composite injection containing lightly modified sodium hyaluronate, hydrogel particles formed by reacting the modified sodium hyaluronate with a polymercapto polyethylene glycol cross-linking agent, and the hydrogel composite injection obtained by mixing the hydrogel particles with a sodium hyaluronate solution. The injection is used for relieving arthralgia and treating degenerative arthritis, has good biocompatibility, can realize one-time administration, long-term effect and increase patient compliance, and almost has no cross-linking agent residue, so that the injection is very safe in application.

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a plaster for treating rheumatic bone diseases and a preparation method of the plaster. The plaster is prepared from raw materials in parts by weight as follows: 3 parts of radix angelicae sinensis, 3 parts of rhizoma ligustici, 3 parts of olibanum, 3 parts of myrrh, 2 parts of ramulus cinnamomi, 2 parts of flos carthami, 2 parts of eupolyphaga sinensis, 2 parts of radix clematidis, 2 parts of lignum sappan, 3 parts of radix achyranthis bidentatae, 2 parts of herba asari, 2 parts of processed radix aconiti kusnezoffii, 2 parts of radix aconiti preparata, 2 parts of rhizoma arisaematis, 2 parts of processed rhizoma pinelliae, 3 parts of radix et rhizoma rhei, 3 parts of common bletilla tuber, 2 parts of bulbus fritillariae thunbergii, 2 parts of radix angelicae, 2 parts of semen strychni, 3 parts of rhizoma curcumae longae, 10 parts of borneol and 500 parts of sesame oil. The multiple Chinese herbal medicines are adopted for joint action and comprehensive treatment, effective components of the medicines permeate into the focus through skin, blood circulation of a location of lesion is improved, local inflammatory edema is promoted to be diminished, muscular tension and spasm are relieved, so that symptoms are rapidly relieved, and the plaster is applicable to various rheumatic bone diseases such as rheumatism, rheumatoid arthritis, degenerative arthritis and the like; the medicine components are low in cost, and the plaster is suitable for industrial production.

The present invention relates to a novel liquid composition comprised of piroxicam or its pharmaceutically acceptable salt (a non-steroid anti-inflammatory drug) and hyaluronic acid or its pharmaceutically acceptable salt (used for treatment of degenerative arthritis).Specifically, the invention provides a highly physicochemically stable liquid injection, comprising piroxicam and hyaluronic acid as active ingredients and β-cyclodextrin or its derivative and polyethylene glycol as additives to enhance its physicochemical stability, and the preparation method thereof.Therefore, the novel composition and the formulation method thereof provided by the present invention may be used to produce a liquid injection composition of piroxicam and hyaluronic acid.

The invention relates to a pharmaceutical preparation for treating knee-joint retrogressive arthritis and application thereof. The pharmaceutical preparation is prepared from pseudo-ginsengs, radix angelicae pubescentis, clematis roots, rhizoma cibotii, longspur epimedium, Chinese caterpillar fungus, cinnamon, safflower carthamus, angelica roots, ground beetles, poria cocos, Chinese wolfberry fruits, fructus forsythiae, radix lithospermi, radix angelica sinensis, radix cyathulae, sophora flavescens, big jujubes, scutellaria baicalensis, lophatherum gracile, dried tangerine peels, honeysuckles, ginger and licorice roots. The raw materials of the pharmaceutical preparation are all pure traditional Chinese medicine raw materials, and the pharmaceutical preparation is scientific and reasonable, has the remarkable effect of treating the knee-joint retrogressive arthritis, is fee of toxic and side effects, enables the knee-joint retrogressive arthritis not to easily relapse and especially has the better effect of treating the early-stage knee-joint retrogressive arthritis. A preparation method of the pharmaceutical preparation is simple in operation, production process involved devices are easy to obtain, and the pharmaceutical preparation is worthy of further popularization and application.

The invention relates to a traditional Chinese medicine combination for treating retrogressive arthritis and preparation method thereof, belonging to pharmaceutical technique field. The traditional Chinese medicine combination is prepared by the following raw materials by weight parts: earthworm, pangolin, pawpaw, chuanxiong rhizome, peach kernel, tetrandra root, cibot rhizome, variegated coralbean bark and Chinese clematis respectively 3-5 weight parts, rosin 10-15 weight parts, oleum sesami 5-10 weight parts. The preparation method of the traditional Chinese medicine combination are as follow: (1) crushing: respectively crushing borneol and camphor and sieving through 80 mesh, for being standby (2) oil refining: decocting oleum sesami to be water-droplet shaped when dribbling, when white oil fume appears, then adding rosin while stirring the oleum sesami, then adding the other medicine powder (3) spreading out: slowly plunging the plaster into cold water and continuously stirring the mixture; drying the plaster in the shade to remove the water, heating plaster to dissolve on water bath, spreading out the dissolved plaster on cloth.