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Modified sodium hyaluronate hydrogel composite injection and preparation method thereof

A technology of sodium hyaluronate and hydrogel, applied in the fields of chemistry and medicine, can solve problems such as potential safety hazards, and achieve the effects of less usage, obvious repairing effect and reasonable proportion

Pending Publication Date: 2022-05-17
SHANGHAI JINGFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Patent CN110016152A discloses a preparation method of sodium hyaluronate gel for cross-linking and filling. The product has certain biocompatibility, but the gel is dehydrated with toxic organic solvents such as acetone and toluene, and the residual solvent is safe for the human body. Hidden danger

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take sodium hyaluronate raw material, use water for injection to prepare 4L of 3% sodium hyaluronate solution; weigh 84.3g of sodium hydroxide, dissolve in 2668ml of water for injection, dissolve the sodium hydroxide solution in the aforementioned sodium hyaluronate solution, mix well, Then add 90ml of 15% DVS solution and react for 16 minutes; then add an appropriate amount of HCl solution to adjust the pH of the reaction solution until the pH is between 4.5-5, and terminate the reaction; wash the reaction solution by ultrafiltration, and freeze it after ultrafiltration Dry to obtain the modified sodium hyaluronate product (HA-VS1).

[0025] Take the obtained HA-VS product, add buffer solution, add water and stir to dissolve, so that the concentration of HA-VS is 1.0%. Take 10 g of the solution, add about a quarter of the modified sodium hyaluronate crosslinking agent aqueous solution, stir and mix evenly, and then stand at 30-40°C for 24 hours. Using a stainless stee...

Embodiment 2

[0027] Take sodium hyaluronate raw material, use water for injection to prepare 4L of 3% sodium hyaluronate solution; weigh 84.3g of sodium hydroxide, dissolve in 2668ml of water for injection, dissolve the sodium hydroxide solution in the aforementioned sodium hyaluronate solution, mix well, Then add 90ml of 15% DVS solution and react for 16 minutes; then add an appropriate amount of HCl solution to adjust the pH of the reaction solution until the pH is between 4.5-5, and terminate the reaction; wash the reaction solution by ultrafiltration, and freeze it after ultrafiltration Dry to obtain the modified sodium hyaluronate product (HA-VS).

[0028] Take the obtained HA-VS product, add buffer solution, add water and stir to dissolve, so that the concentration of HA-VS is 25.0%. Take 10 g of the solution, add about a quarter of the modified sodium hyaluronate crosslinking agent aqueous solution, stir and mix evenly, and then stand at 30-40°C for 24 hours. Using a stainless stee...

Embodiment 3

[0030] Take the sodium hyaluronate raw material, use water for injection, prepare 4L of 3% sodium hyaluronate solution; weigh 84.3g of sodium hydroxide, dissolve it in 2668ml of water for injection, dissolve the sodium hydroxide solution in the aforementioned sodium hyaluronate solution, and mix well , then add 90ml of 15% DVS solution, and react for 16 minutes; then add appropriate amount of HCl solution, adjust the pH of the reaction solution until the pH is between 4.5-5, and terminate the reaction; wash the reaction solution by ultrafiltration, and carry out after ultrafiltration Freeze-dry to obtain modified sodium hyaluronate product (HA-VS).

[0031] Take the obtained HA-VS product, add buffer, add water and stir to dissolve, so that the concentration of HA-VS is 50%. Take 10 g of the solution, add about a quarter of the modified sodium hyaluronate crosslinking agent aqueous solution, stir and mix evenly, and then stand at 30-40°C for 24 hours. Using a stainless steel ...

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Abstract

The invention provides a preparation method of a hydrogel composite injection containing lightly modified sodium hyaluronate, hydrogel particles formed by reacting the modified sodium hyaluronate with a polymercapto polyethylene glycol cross-linking agent, and the hydrogel composite injection obtained by mixing the hydrogel particles with a sodium hyaluronate solution. The injection is used for relieving arthralgia and treating degenerative arthritis, has good biocompatibility, can realize one-time administration, long-term effect and increase patient compliance, and almost has no cross-linking agent residue, so that the injection is very safe in application.

Description

technical field [0001] The invention relates to the fields of chemistry and medicine, specifically, sodium hyaluronate is slightly modified by addition reaction, and the modified sodium hyaluronate is cross-linked with specific polyethylene glycol derivatives to form polymer water Gel, and the mixed injection formed by the hydrogel and sodium hyaluronate solution. The injection can be used to treat degenerative arthritis and relieve joint pain. Background technique [0002] Hyaluronic acid, also known as hyaluronic acid (HA for short), is a biologically active macromolecule with N-acetylglucosamine and β-D-glucuronic acid disaccharide units as the basic structural units. Sodium hyaluronate is a transparent The sodium salt form of uric acid has almost the same physical and chemical properties. [0003] Hyaluronic acid and its salts are acidic mucopolysaccharides ubiquitous in living organisms. Human skin, cartilage, eye vitreous and synovial fluid all contain high concentra...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/08A61K31/728A61K47/20A61P19/02A61P29/00
CPCA61K9/06A61K9/0019A61K9/08A61K31/728A61K47/20A61P19/02A61P29/00
Inventor 张延良邱永锋张龙刘珊李杰
Owner SHANGHAI JINGFENG PHARMA
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