33 results about "Associated substance" patented technology

The present invention relates to a novel method of obtaining a factor involved in appetite control and / or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and / or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and / or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and / or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and / or body weight control.

The present invention provides a method for effectively exerting a cell proliferation promoting effect of a purine nucleic acid-related substance. The present invention provides a composition for cell proliferation containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. Further, the present invention provides a method for potentiating the cell proliferation promoting effect of the purine nucleic acid-related substance by using the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance. Still further, the present invention provides a method for promoting cell proliferation, where the method comprising applying purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance to the skin or mucosa.

An apparatus and also a method for calibration of a spectrometer for the measurement of spectral fractions of a substance (4) as a part of chemometry or chemometric processes are proposed, with a spectrometer device (1) for measuring of spectral fractions of the substance (4) to be analysed, and also with a calibration unit (2) used to carry out a calibration of the spectrometer device and / or of the measured data on the basis of measured spectrometric data, characterized by the following steps: a) measuring the totality of spectral fractions X and / or of associated substance concentrations of the substance (4) under analysis; b) Saving the totality of measured spectral fractions X in a memory module (3) as spectrometric measured data in the form of a multi-dimensional coefficient vector; c) From the totality of measured spectral fractions X, automatic extraction of spectral fractions Xrel physically relevant to the particular measuring process by means of an automatically running, iterative estimation method saved in the calibration unit (2); d) Calibration of the measured spectrometric data for the analysed substance (4) on the basis of spectral fractions Xrel of the spectrometric data extracted in step c) and which are physically relevant to the substance (4) under analysis.

An environment-related substance insurance system and a computer program. Provides computer systems and computer programs for calculating appropriate insurance premiums to be paid by policyholders to insurers in order to realize environmental-related substance insurance that guarantees environmental-related substance-containing accidents. Provided is an environment-related substance insurance system that calculates insurance premiums for environment-related substance insurance that compensates for losses when products of an insured person contain environment-related substances due to accidents, characterized by having: an input / output processing unit (23) inputting at least information specifying environment-related substances as insurance targets and information on analysis results of products related to the contractor as contractor information related to the insured; 21); an insurance premium calculation unit (CPU22) that calculates an insurance premium based on the contracting party information stored in the contracting party information storage unit (21).

This invention relates to an oral pharmaceutical formulation formed by a direct coating of an enteric layer containing polyethylene glycol as a plasticizer on a core containing an acid-labile pantoprazole, and its manufacturing method. The enteric-coated oral pharmaceutical formulation of this invention, which combines directly a core containing an acid-labile pantoprazole and an enteric layer in the absence of an inert intermediate layer, is able to improve the storage stability of the acid-labile pantoprazole and maximize the bioavailability and oral absorption rates via preventing related substances from increasing.

The present invention provides combined use of a carnosinase inhibitor with L-carnosine and its related substance, and a composition containing the same, which are useful for treatment or prevention of various diseases, improvement of health conditions, improvement of exercise ability, improvement of skin health, prevention of the side effects of alcohol drinking and the like in mammals including human.

The present invention relates to a novel method of obtaining a factor involved in appetite control and / or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and / or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and / or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and / or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and / or body weight control.

A computer-implemented method for automatic peak integration of at least one chromatogram of at least one sample is presented. The sample comprises at least one analyte and at least one chemically related substance. The method comprises the steps of: a) retrieving at least one chromatogram of the chemically related substance and at least one chromatogram of the analyte; (114, 116) b) evaluating the chromatogram of the chemical related substance, wherein the evaluation comprises b1) determining a retention time (118) of the chemical-related substance and adding the retention time of the chemical-related substance to a predetermined or predefined constant offset and / or multiplying the retention time of the chemical-related substance by a predetermined or predefined constant factor (120), b) determining at least one initial value (117) of the analyte retention time by determining a peak shape parameter (121) of at least one peak of the chromatogram of the chemically relevant substance, b2) determining at least one initial value (122) of an analyte peak shape parameter by determining a peak shape parameter (121) of at least one peak of the chromatogram of the chemically relevant substance; c) evaluating the chromatogram of the analyte, where the evaluation comprises c1) at least one step (124) of position determination, where the analyte retention time is determined by taking into account the initial value of the retention time of the chemically relevant substance; c2) at least one peak integration step (126) in which at least one fitting analysis is applied to the chromatogram of the analyte by taking into account an initial value of an analyte peak shape parameter and the analyte retention time, thereby determining an analyte peak area and an analyte peak shape.

The present invention relates to a new HPLC method for the analysis of the drug substance bosentan and related substances and to the use of said substances as reference standards and markers.

A method for preparing a transdermal absorption composition includes mixing rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1. A transdermal therapeutic system includes a substrate and a drug-containing adhesive layer disposed on the substrate and including an antioxidant at a weight ratio of 1:0.0001 to 0.1. The method and system of the present invention suppress the crystallization of rotigotine as well as the generation of related substances, thereby increasing the long-term storage stability of a therapeutic product containing rotigotine or related substances.

The disclosed device for trapping biologically-relevant substances can easily collect biologically-relevant substances from a thin tissue section or a gel in which said biologically-relevant substance have been fractionated. Said device is provided with: trapping bodies for trapping biologically-relevant substances; carriers that hold the trapping bodies; and electrodes for charging the trapping bodies. The trapping bodies are charged and brought into contact with a prescribed position on a thin tissue section that contains biologically-relevant substances or a gel in which biologically-relevant substances have been fractionated, thereby trapping said biologically-relevant substances from said gel or thin tissue section.

A method for effectively exerting a cell proliferation promoting effect of a purine nucleic acid-related substance, and a composition for cell proliferation containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. Also a method for potentiating the cell proliferation promoting effect of the purine nucleic acid-related substance by using the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance and a method for promoting cell proliferation, where the method includes the step of applying the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance to the skin or mucosa.

A process for synthesizing the propionyl-L-carnitine features the acylation reaction between L-carnitine and propionyl chloride in propionic acid as solvent under the catalysis of p-toluenesulfonic acid. The method for measuring the contents of propionyl-L-carnitine and associated substances features that the efficient liquid-phase chromatography is used to measure the content of propionyl-L-carnitine and the thin-layer chromatography is used to detect associated substances.

This invention relates to process method to test cefuroxime and its salt materials and the method for polymer comparing product solution. The invention solves the comparing cefuroxime and dilutes it to the needed concentration and adjusts its Ph value above nine as alkalescence solution and to make it totally associated under certain temperature and time. The process method in the invention has complete cefuroxime and stable associated substance and stable peak area of associated substance.