Combined therapy

A compound, tissue-damaging technology, applied in the field of combination therapy, can solve problems such as delayed tissue sodium overload

Inactive Publication Date: 2002-09-25
PFIZER PRODS ETAT DE CONNECTICUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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Embodiment Construction

[0010] The present invention provides a method of reducing tissue damage (e.g., substantially preventing tissue damage and / or producing tissue protection) due to ischemia comprising, administering to a mammal (e.g., human, male) in need of such reduction or female) administering a therapeutically effective amount of a type 1 sodium-hydrogen exchanger (NHE-1) inhibitor and selected from (a) a complement modulator, (b) a metabolic modulator, (c) an anti-apoptotic agent, (d) ) nitric oxide synthase-related substances and (e) selected from protein kinase C activators, endothelin-converting enzyme inhibitors, tissue-activated fibrinolysis inhibitors (TAFI), Na + / Ca +2 Combination of a second compound of an enzyme / protein modulator of an exchanger isoform-1 (NCX-1) inhibitor and a poly(ADP-ribose) synthetase (PARS / PARP) inhibitor, or a medicament containing the combination combination.

[0011] Preferred ischemic tissues that may be treated according to the method of the present ...

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Abstract

The present invention provides a method of reducing tissue damage due to ischemia, the method comprising, administering to a mammal in need of such reduction an effective amount of an NHE-1 inhibitor and an agent selected from (a) a complement modulator, (b) A combination of a metabolic regulator, (c) an anti-apoptotic agent, (d) a nitric oxide synthase-related substance and (e) a second compound of an enzyme/protein regulator, or a pharmaceutical composition containing the combination. The present invention also provides a kit comprising an amount of a type 1 sodium-hydrogen exchanger inhibitor in a first unit dosage form and a pharmaceutically acceptable carrier, excipient or diluent; an amount of the second compound in a form and a pharmaceutically acceptable carrier, excipient or diluent; and a container.

Description

field of invention [0001] The present invention relates to the use of sodium / hydrogen exchange type 1 (NHE-1) inhibitors and agents selected from (a) complement modulators, (b) metabolic modulators, (c) anti-apoptotic agents, (d) nitric oxide synthase A method of reducing tissue damage due to ischemia with a combination of a related substance and (e) a second compound of an enzyme / protein modulator or a pharmaceutical composition of said combination. The invention also provides kits related to said combinations. Background of the invention [0002] Ischemic injury, particularly of the myocardium, can occur both as an outpatient and during surgery and can lead to sudden death, myocardial infarction, or congestive heart failure. There is still a need in medicine for methods of preventing or minimizing myocardial ischemic injury, especially myocardial infarction during surgery. Such therapies are expected to save lives and reduce the need for hospitalization in high-risk pati...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K31/166A61K31/18A61K31/19A61K31/192A61K31/198A61K31/336A61K31/404A61K31/415A61K31/4155A61K31/416A61K31/4184A61K31/4192A61K31/4709A61K31/4725A61K31/4745A61K45/06A61P9/00A61P9/04A61P9/10A61P41/00A61P43/00
CPCA61K31/4709A61K31/4725A61K31/4745A61K45/06A61P41/00A61P43/00A61P7/00A61P9/00A61P9/04A61P9/10A61K2300/00A61K31/415
Inventor W·R·特拉斯R·J·赫尔
Owner PFIZER PRODS ETAT DE CONNECTICUT
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