43 results about "Antipsychotic drug" patented technology

New methods of treating schizophrenia and schizoaffective disorder by administration of pharmaceutical compositions comprising an antipsychotic compound and a VMAT2 inhibitor to a subject in need thereof are provided.

The invention provides methods for the treatment of abnormal psychiatric states, particularly the negative symptoms of schizophrenia and extrapyramidal side effects (EPS) of antipsychotic drugs. The inventive methods relate to the administration of therapeutic cells (which produce dopamine or dopamine precursors) adhered to support matrices to subjects suffering from the negative symptoms of schizophrenia and / or EPS. The therapeutic cells may be coadministered with cells which protect the therapeutic cells from immune rejection and / or cells which produce neurotrophic factors which improve the viability of the therapeutic cells.

Polycondensated heterocycles with a pyrrole[2,1-b][1,3]benzothiazepine structure of the following formula (I)where the groups are defined as in the description are disclosed. As compared to known antipsychotic agents, these compounds present substantial activity associated with a simultaneous reduction in unwanted extrapyramidal symptoms. These compounds can be formulated in pharmaceutical compositions for the treatment of psychoses such as, for example, schizophrenia.

The present invention provides an antipsychotic drug comprising fasudil or a pharmaceutically acceptable salt thereof as an active agent for the treatment of schizophrenia, including schizophrenia caused by dysfunction of ARHGAP10.

Provided herein are methods of treatment of psychiatric disorders requiring treatment with an antipsychotic drug, such as schizophrenia or schizoaffective disorder, comprising administration of both the antipsychotic drug and a W. somnifera plant part, extract, chemical constituent(s) thereof, or a derivative thereof to treat symptoms of the psychiatric disorder. Treatment is typically continued for at least four weeks. A combination dosage form comprising both the antipsychotic drug and the W. somnifera plant part, extract, chemical constituent(s) thereof, or a derivative thereof in amounts effective to treat the psychiatric disorder.

Methods for detecting resistance to sedation caused by antipsychotic drugs including methods for detecting psychotic disorders such as but not limited to schizophrenia or bipolar I disorder featuring administering to a patient a dose of an antipsychotic medication; and subjecting the patient to an evaluation at a time point following administration of the dose of the antipsychotic medication. The evaluation is adapted to determine a level of sedation resulting from the dose of the antipsychotic medication. A resulting level of sedation may be one of the following: completely sedated, significantly sedated, moderately sedated, not significantly sedated and completely alert. If the individual is not completely sedated or significantly sedated, or is completely alert, then the patient may have a likelihood of having a psychotic disorder such as schizophrenia.

The invention relates to a preparation method of an antipsychotic drug olanzapine. The method comprises three steps: first, using sulfur, propionaldehyde and malononitrile as raw materials, triethylamine as a catalyst to carry out ringclosure to obtain 5-methyl-2-amino-3-cyanothiophene; second, the 5-methyl-2-amino-3-cyanothiophene and o-fluoronitrobenzene generating 5-methyl-2-(2- nitrophenylamino)-3-cyanothiophene under effects of sodium hydride; third, the 5-methyl-2-(2- nitrophenylamino)-3-cyanothiophene reacting with hydrazine hydrate and N-methyl piperazine to carry out ringclosure reaction under existence of ferric trichloride / active carbon catalyst; so as to generate objective compound olanzapine through a one-pot method. The invention has the advantages of cheap and easily available raw materials, few steps, and simple process. A one-pot reaction is carried out in the third step, so that intermediate state compounds during the reaction process do not need to be separated or removed and can converse into the objective compound, and the high-purity olanzapine can be obtained with high yield. The whole process is suitable for industrial mass production with high product yield, low costs and convenient post-treatment.