257 results about "Depressed - symptom" patented technology

The present invention relates to a new method of treatment for persons meeting diagnoses for major depressive disorder, or other unipolar (non-bipolar, non-psychotic and non-treatment resistant) depression. The method comprises administering a combination of two categories of drugs, antipsychotics or dopamine system stabilizers, in combination with a newer antidepressant such as a selective serotonin reuptake inhibitor, as initial treatment or as soon as possible. The method targets the prevention of suicide, and provides other benefits including preventing disease progression development of tolerance toward the antidepressants. Another aspect of the invention relates to using the method for alleviating cognitive distortion and related functional impairment or health risks, and / or using the method for smoking cessation or nicotine withdrawal.

The invention discloses application of Akkermansia Muciniphila in preparing a drug or health-care product for preventing and treating depression. In the application, in vivo pharmacodynamic research is performed on the effect of the Akkermansia Muciniphila in incidence of the depression and depression resistance; a result shows that abundance of the Akkermansia Muciniphila in an intestinal tract of a patient with the depression is obviously lowered; and a result of an animal experiment shows that abundance of the Akkermansia Muciniphila in an intestinal tract of a mouse with the depression isremarkably lowered. In the application disclosed by the invention, the Akkermansia Muciniphila is transplanted into a model of the mouse with the depression; and tests show that through Akkermansia Muciniphila transplantation, a movement distance of the mouse can be increased, the immobility times of a tail suspension test and a forced swimming test can be shortened, the depression state of the mouse is remarkably relieved, and the Akkermansia Muciniphila shows very good anti-depression curative effect without side effect.

Method and apparatus to measure jitter (period-to-period fluctuations in fundamental frequency) among the voices of suicidal, major depressed, and non-suicidal patients to predict near-term suicidal risk.

The present invention differentiates objective disease labels for depression symptoms relative to brain activity states. As one means to address the problem to be addressed thereby, the present invention provides a differentiation device that is for helping to determine whether a subject has depression symptoms. The differentiation device comprises a storage device that is for storing informationthat specifies a classifier that has been generated by classifier generation processing from signals obtained by using a brain activity detection device to chronologically premeasure signals that indicate brain activity in a plurality of prescribed regions of the resting brains of each of a plurality of participants that include healthy and depressive patients. The classifier: is generated on thebasis of a weighted sum of a plurality of functional connectivities that, from among functional connectivities between the plurality of prescribed regions, have, by means of machine learning, been selected by feature selection as being related to disease labels for depression symptoms; and is generated to differentiate the disease labels for depression symptoms. The differentiation device also comprises a computing device. Using the classifier, the computing device executes differentiation processing that generates classification results for the depression symptoms of the subject.