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Novel depression biomarker and application thereof

A technology for biomarkers and depression, applied in biomaterial analysis, measuring devices, instruments, etc.

Active Publication Date: 2020-08-07
CHONGQING MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These abnormal brain theories provide an important theoretical basis for revealing the pathophysiological mechanism of depression, but most of them can only explain some aspects of the reasons

Method used

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  • Novel depression biomarker and application thereof
  • Novel depression biomarker and application thereof
  • Novel depression biomarker and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Example 1. Screening of intestinal biomarkers for diagnosis of depression

[0107] method

[0108] 1. Sample source

[0109] Outpatients and community health volunteers in Beijing Anding Hospital were recruited to collect stool samples. The inclusion criteria were as follows:

[0110] 1.1 Inclusion criteria for patients with depression:

[0111] (1) Patients aged 18-65 years, regardless of gender, who meet the diagnostic criteria for depressive disorder in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV);

[0112] (2) Hamilton Depression Rating Scale-17 (HAMD-17) score ≥ 14 points;

[0113] (3) Have a certain level of education and be able to cooperate in completing the assessment and follow-up;

[0114] (4) Patients sign the informed consent.

[0115] 1.2 Inclusion criteria for healthy controls:

[0116] (1) Gender, age, education level, place of residence, etc. are matched with the case group, and the diagnostic evaluati...

Embodiment 2

[0155] Example 2. Using random forest (Random Forest, RF) to verify the intestinal biomarkers of depression

[0156] In order to further verify the intestinal biomarkers of disease, this embodiment constructed a training set of biomarkers of depressed subjects and healthy controls, and based on this, the biomarker content values ​​of the samples to be tested were evaluated. Wherein, in this disclosure, the training set and the verification set have meanings known in the art. In the embodiment of the present disclosure, the training set refers to a data set containing the content of each biomarker in a certain number of samples of depression subjects and healthy control samples to be tested. The validation set is an independent data set used to test the performance of the training set. From 311 samples (156 depression patients and 155 healthy people), this disclosure selects 118 depression patients who have not used antidepressants in the past month and 118 matched healthy peo...

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Abstract

The invention provides a depression intestinal biomarker and application thereof. The intestinal biomarker is selected from one or more of intestinal microorganisms and excrement metabolites. The invention further provides a kit for diagnosing depression and a screening method for screening the biomarker for depression.

Description

technical field [0001] The disclosure belongs to the field of biotechnology, and specifically relates to the application of intestinal microorganisms, fecal metabolites and / or their combination in the diagnosis of depression, and the screening of intestinal biomarkers and / or intestinal biological markers of depression patients. Methods for marker panels. Background technique [0002] Depression is a common psychiatric disorder in which genes and the environment interact. The main clinical features are marked and persistent depression and loss of interest, and severe cases may even have suicidal tendencies. Epidemiological data show that the prevalence of depression in the world is about 4.4%, and there are 322 million patients with depression. In China, depression has become the second most common disease after heart disease. Therefore, it is imminent to strengthen the research on the prevention and treatment of depression and its pathogenesis. Previous studies on the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569
CPCG01N33/56983G01N33/56911G01N33/56916G01N2800/304
Inventor 王刚杨健郑鹏孙作厘
Owner CHONGQING MEDICAL UNIVERSITY
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