33 results about "Ajoene" patented technology

The present invention provides a composition for removing a hangover. In particular, the present invention discloses a method of using ajoene as an alcohol dehydrogenase inhibitor based on the fact that ajoene strongly inhibits alcohol dehydrogenase (ADH) activity. A composition for removing a hangover comprising ajoene suppresses the over-production of acetaldehyde during alcohol metabolism to maintain acetaldehyde concentration in blood at a normal level that can be degraded in the body and eliminated therefrom through normal metabolic and secretory pathways to thereby prevent the hangover after consumption of alcohol, and a method of preparing the same, are also provided. The present invention also provides a novel use of ajoene, which is a natural substance obtained by purification of garlic, and a composition for removing a hangover comprising ajoene, which is harmless to the body and strongly inhibits ADH activity, thereby showing very excellent relieving effect on the hangover.

The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C═C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

A single-particle nano-allicin microcapsule, which is composed of a single-particle garlic active ingredient and a wall material embedded outside it, the wall material is N-LOK modified starch or β-CD, and the active ingredients include allicin, allicin, Ajoene, Selenium and Germanium. Preparation steps: put the washed and purified garlic raw material in a container, then add ethanol, dichloromethane or water solvent with a concentration of 70-100%, put it into a multi-dimensional microwave environment for multi-dimensional microwave-induced extraction, and the extraction temperature is 40-50°C , the extraction pressure is 0.06-0.12Mpa, and its active ingredients are extracted into the solvent; after being filtered, it is sent to the concentration tank for concentration under reduced pressure to obtain a mixed extract containing the active ingredients of garlic; the active ingredients are obtained by condensation; the concentrated solution is added N-LOK modified starch or β-CD, stirred at low temperature to make a mixture liquid, and then sent to the ring-shaped nano-jet atomizer for atomization and drying, so as to obtain single-particle nano-garlicin microcapsules and make them into powder, tablets or Capsule dosage form; it has the advantages of high extraction rate and basically no damage to plant active ingredients.

The present invention relates to a process for producing ajoene from allicin via a polymeric substrate, comprising the steps of heating allicin or an allicin solution at a predetermined temperature range such that at least a portion of the allicin is converted to ajoene to form an ajoene solution; and separating the ajoene from the ajoene solution; wherein at least one of the heating or separating steps is conducted via a polymeric substrate. The process for producing ajoene from allicin via a polymeric substrate further comprises a step of retaining the allicin or the allicin solution on the polymeric substrate before the heating step is conducted within or out of the polymeric substrate. The present invention also relates to ajoene or a composition comprising ajoene obtained by the process thereof.

The invention relates to a garlic ajoene reference substance preparation method. The preparation method comprises the following steps: 1) crushing garlic, adding a solvent, performing high- pressure homogeneous extraction, filtering the material to obtain an extract; 2) adding the solvent in the extract for extraction, standing and layering the material, taking an upper layer of the solution to obtain an extract; 3) performing vacuum concentration on the extract, through silica-gel column chromatography, eluting the solvent to obtain an eluate; 4) performing vacuum concentration on the eluate, through separating and purifying a liquid phase to obtain the ajoene-rich eluate; and 5) performing vacuum concentration on the eluate to obtain the ajoene reference substance. Each index of four spectrums and purity determination of the ajoene reference substance can be accorded with a national standard. The method is simple and stable, is used for preparing the garlic ajoene reference substance, and provides the technical support for deep research of ajoene.

The present invention relates to an ajoene preparation method, which comprises: (1) crushing garlic, and adding an extraction solution to mix so as to obtain a product A; (2) extracting the product A, and then carrying out a filtration and / or centrifugation treatment to obtain a solution, ie., product B; (3) removing the solvent from the product B, and adding vegetable oil to mix so as to obtain a product C; (4) adding the product C to an adsorbent to mix so as to obtain a product D; (5) eluting the product D with an eluant-containing solution to obtain a product E; and (6) removing the solvent from the product E so as to obtain the product containing the high concentration ajoene. According to the new method of the present invention, the defects in the existing preparation method are improved, and the new method has advantages of adaptability to industrial production, short production cycle, environmental protection, high ajoene purity, high utilization of raw material residue, and the like.