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A kind of preparation method of ajoene

An ajoene and product technology, which is applied in the field of chemical preparation of active substances, can solve the problems of complex preparation process, high requirements for equipment and external environment, and achieve the effects of shortening extraction time and simple production operation.

Active Publication Date: 2016-08-24
冼少华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of ajoene provided by the prior art has a complicated preparation process, high requirements on equipment and external environment, and is not suitable for industrial production and application. Therefore, there is an urgent need for a method for producing ajoene with a simple preparation process and can be produced in batches in an industrialized manner.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A method for preparing ajoene using garlic as a raw material, comprising the steps of:

[0068] 1. Get 20kg of garlic from Yunnan, peel it, crush it with a press and grinder, control the particle size of the crushed garlic to be about 0.3cm, add 40kg of 50% ethanol, and mix.

[0069] 2. The above mixture was left at room temperature for 24 hours, filtered through a 200-mesh industrial sieve, the filtrate was taken, and the filter residue was centrifuged with a centrifuge at a speed of 2500 rpm to obtain a solution. The above-mentioned filtrate and the solution obtained by centrifugation were combined and set aside.

[0070] 3. Under the conditions of a heating temperature of 60-70°C and a vacuum degree of 0.060-0.080 MPa, the ethanol in the above solution is evaporated until the solution has no ethanol smell, and a concentrated solution is obtained.

[0071]4. Add 2kg of rapeseed oil to the above concentrate, mix and set aside. (Using the method provided in the prior ...

Embodiment 2

[0077] A method for preparing ajoene using garlic as a raw material, comprising the steps of:

[0078] 1. Get 20kg of garlic from Yunnan, peel it, crush it with a press and pulverize it with a pulverizer, control the crushed garlic particle size to be about 0.1cm, add 60kg of 70% ethanol, and mix.

[0079] 2. The above mixture was left at room temperature for 24 hours, filtered through a 200-mesh industrial sieve, the filtrate was taken, and the filter residue was centrifuged with a centrifuge at a speed of 2500 rpm to obtain a solution. The above-mentioned filtrate and the solution obtained by centrifugation were combined and set aside.

[0080] 3. Under the conditions of a heating temperature of 60-70°C and a vacuum degree of 0.060-0.080 MPa, the ethanol in the above solution is evaporated until the solution has no ethanol smell, and a concentrated solution is obtained.

[0081] 4. Add 2kg of rapeseed oil to the above concentrate, mix and set aside.

[0082] 5. Take 2kg of...

Embodiment 3-5

[0090] In this embodiment, the effect of the crushed particle size of garlic on the content of ajoene in the product is determined.

[0091] In the prior art, it is considered that the smaller the crushed particle size of garlic, the more beneficial it is to increase the yield of ajoene. For this, the scheme in Example 2 is adopted, but the crushed particle size of garlic is different.

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Abstract

The present invention relates to an ajoene preparation method, which comprises: (1) crushing garlic, and adding an extraction solution to mix so as to obtain a product A; (2) extracting the product A, and then carrying out a filtration and / or centrifugation treatment to obtain a solution, ie., product B; (3) removing the solvent from the product B, and adding vegetable oil to mix so as to obtain a product C; (4) adding the product C to an adsorbent to mix so as to obtain a product D; (5) eluting the product D with an eluant-containing solution to obtain a product E; and (6) removing the solvent from the product E so as to obtain the product containing the high concentration ajoene. According to the new method of the present invention, the defects in the existing preparation method are improved, and the new method has advantages of adaptability to industrial production, short production cycle, environmental protection, high ajoene purity, high utilization of raw material residue, and the like.

Description

technical field [0001] The invention relates to a method for preparing active substances by a chemical method, in particular to a method for preparing ajoene. Background technique [0002] Garlic has been used for thousands of years as a culinary herb and food. Additionally, garlic has many medicinal properties and has been used in folk medicine for thousands of years. [0003] Ajoene is a naturally occurring compound obtained from garlic. More specifically, ajoene is formed during the degradation of allicin, a chemically unstable, colorless to straw-colored oil thought to be responsible for much of garlic's odor and biological activity. Intact garlic cloves do not contain allicin, whereas the odorless precursor alliin [(+)(S-allyl-L-cysteine ​​sulfoxide)] contains allicin. This precursor is converted to allicin by a C-S-lyase called alliinase present in the garlic plant. Alliin and alliinase are found in different compartments of the garlic clove, and cutting or breakin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C323/65C07C319/28
Inventor 冼少华黄伟昌
Owner 冼少华
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