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Single particle nano-garlicin micro-capsule, and its preparation method

A technology of single particle and allicin, which is applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of high processing cost, no process and dosage form, and no nano-scale allicin products, so as to reduce blood lipids, Activate phagocytosis and enhance human immune function

Inactive Publication Date: 2006-04-26
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

We consulted 7 related literatures, including CN1408417A, CN1366837A, CN1111044C, CN1246342A, CN1214209A, CN1365681A, WO2003024437, etc., although they all have unique ideas, they either simply processed them as health food or feed, or adopted supercritical fluid extraction. , molecular distillation and other technical means with very high processing costs, and have not made nano-scale allicin products, that is, the technology and dosage forms covered by the present invention have no

Method used

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  • Single particle nano-garlicin micro-capsule, and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Fig. 1 is the technological process schematic diagram of preparing single-particle nano-allicin microcapsules of the present invention; Accompanying drawing 2 is the schematic diagram of the positional relationship between the high-pressure spray nozzle in the feed pipe 8 and the annular nano-jet atomizer 4;

[0036] The steps for preparing single-particle nano-allicin microcapsules in this embodiment are:

[0037] 1) Select 400 kg of fresh garlic as a raw material and put it into the washing container 1, and wash and purify it with distilled water;

[0038] 2) Put the washed and purified garlic raw material in a container, then add 90% ethanol (of course, 70% ethanol is also acceptable) solvent to immerse the garlic raw material, put it into the multidimensional microwave environment 2 for multidimensional Microwave-induced extraction, the extraction temperature is 50°C, the extraction pressure is 0.12Mpa, the active ingredients in the garlic raw material are extracted...

Embodiment 2

[0045] The steps of preparing single particle nano allicin microcapsules of present embodiment 2 are:

[0046] 1) Select 700 kg of fresh garlic as a raw material and put it into the scrubber 1, and wash and purify it with distilled water;

[0047] 2) Put the washed and purified garlic raw material in a container, then add dichloromethane with a concentration of 100%, the amount of which is limited to immerse the garlic raw material, put it into a multi-dimensional microwave environment 2 for multi-dimensional microwave-induced extraction, The extraction temperature is 40°C, the extraction pressure is 0.06Mpa, and the active ingredients in the garlic raw material are extracted into the solvent, and the active ingredients include allicin, allicin, ajoene, selenium and germanium;

[0048] 3) The extract solution is filtered and sent to the concentration tank 3, and concentrated under reduced pressure at 50° C. to obtain a mixed extract concentrate containing garlic active ingredi...

Embodiment 3

[0054] The steps of present embodiment 3 preparation single-particle nano allicin microcapsules are:

[0055] 1) Select 700 kg of fresh garlic as a raw material and put it into the scrubber 1, and wash and purify it with distilled water;

[0056] 2) Put the washed and purified garlic raw material in a container, then add distilled water until the amount of water has submerged the raw material, put it into a multi-dimensional microwave environment 2 for multi-dimensional microwave-induced extraction, the extraction temperature is 45°C, and the extraction pressure is 0.10 Mpa, the active ingredients in the garlic raw material are extracted into the solvent, and the active ingredients include allicin, allicin, ajoene, selenium and germanium;

[0057] 3) The extract solution is filtered and sent to the concentration tank 3, and concentrated under reduced pressure at 30° C. to obtain a mixed extract concentrate containing garlic active ingredients, and the mixed extract concentrate...

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Abstract

A single-particle nano-allicin microcapsule, which is composed of a single-particle garlic active ingredient and a wall material embedded outside it, the wall material is N-LOK modified starch or β-CD, and the active ingredients include allicin, allicin, Ajoene, Selenium and Germanium. Preparation steps: put the washed and purified garlic raw material in a container, then add ethanol, dichloromethane or water solvent with a concentration of 70-100%, put it into a multi-dimensional microwave environment for multi-dimensional microwave-induced extraction, and the extraction temperature is 40-50°C , the extraction pressure is 0.06-0.12Mpa, and its active ingredients are extracted into the solvent; after being filtered, it is sent to the concentration tank for concentration under reduced pressure to obtain a mixed extract containing the active ingredients of garlic; the active ingredients are obtained by condensation; the concentrated solution is added N-LOK modified starch or β-CD, stirred at low temperature to make a mixture liquid, and then sent to the ring-shaped nano-jet atomizer for atomization and drying, so as to obtain single-particle nano-garlicin microcapsules and make them into powder, tablets or Capsule dosage form; it has the advantages of high extraction rate and basically no damage to plant active ingredients.

Description

technical field [0001] The invention is a preparation process and related dosage forms for processing natural medicines by biotechnology. Background technique [0002] Nanotechnology is the cutting-edge science of the 21st century. Basic and applied research is on the rise. The application fields of new nanomaterials are becoming wider and wider. The main method is to use the surface effects and other characteristics of new nanomaterials, combined with the original functions and functions of related products. Dosage forms, to improve and improve, to expand the scope of application. At present, there are no products of allicin nano-scale microcapsules on the market. We consulted 7 related literatures, including CN1408417A, CN1366837A, CN1111044C, CN1246342A, CN1214209A, CN1365681A, WO2003024437, etc., although they all have unique ideas, they either simply processed them as health food or feed, or adopted supercritical fluid extraction. , molecular distillation and other te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/105A61K9/50A61K36/8962A61P9/10A61P31/00A61P35/00A61P43/00
Inventor 赫荣乔杨佳荣赫坚
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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