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Ajoene microcapsule powder product and its preparation method and use

A technology of ajoene and microcapsules, which is applied in the preparation of ajoene microcapsule powder products, ajoene microcapsule powder products and its application fields, and can solve the problems of cumbersome preparation process, cumbersome steps, and low ajoene content, etc. problems, to achieve the effect of expanding the application area, good stability and simple operation

Inactive Publication Date: 2016-11-02
青岛博恩高科生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although ajoene is the conversion product of allicin, because the existing ajoene preparation process is cumbersome, the cost is high, and it is difficult to carry out industrial production, therefore, it is still rare to see ajoene as the main active ingredient in the market. health food and medicine
Patents CN 102356064 and CN 103328441 respectively introduce a process for converting allicin into ajoene in a polar solvent, but the steps are relatively cumbersome, and the cost is high, the toxicity is high, and it is difficult to solve the problem of reagent residue, and the obtained The product is liquid oil, and the application of the preparation is narrow
Patent US 5612077 introduces a process for preparing ajoene products by soaking fresh garlic in oil, but the content of ajoene in the final product is relatively low

Method used

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  • Ajoene microcapsule powder product and its preparation method and use
  • Ajoene microcapsule powder product and its preparation method and use
  • Ajoene microcapsule powder product and its preparation method and use

Examples

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preparation example Construction

[0026] One aspect of the embodiments of the present invention provides a method for preparing ajoene microcapsule powder products, including:

[0027] S1: Extract the allicin-containing raw material with water, and filter to obtain an allicin aqueous solution.

[0028] In this step, water is used to extract allicin-containing raw materials, after the water dissolves and disperses the allicin-containing raw materials into a paste, stir and place for 20-30 minutes, and then filter by centrifugation or filtration to obtain allicin Aqueous solution, which can be filtered by gauze filter. It can be understood that, in this step, the water used is preferably pure water or distilled water in industrial production to ensure food safety.

[0029] S2: using an organic solvent to extract allicin in the allicin aqueous solution, collecting the organic solvent phase, removing water and evaporating it to dryness to obtain allicin-containing garlic oil.

[0030] In this step, an organic so...

Embodiment 1

[0046] Weigh 1 kg of garlic grains, make a paste with water, stir and place for 20 minutes, filter the allicin aqueous solution with gauze, wash the residue twice with water, and combine the supernatant;

[0047] Extract the aqueous allicin solution twice with an equal volume of ethyl acetate, combine the ethyl acetate phases, and remove water with anhydrous sodium sulfate;

[0048] Add the combined ethyl acetate phase into the spinner flask, control the temperature at 30°C, and spin dry the solvent to obtain allicin-containing garlic oil;

[0049] Weigh 50g of β-cyclodextrin and add 300mL of water, stir it into a slurry to obtain an aqueous solution of β-cyclodextrin; add an equal volume of absolute ethanol to the garlic oil containing allicin, adjust it into an ethanol solution of allicin, and add Put it into the β-cyclodextrin aqueous solution, stir evenly, and add the material into the material tank of the colloid mill, adjust the gap between the conical rotating gear and ...

Embodiment 2

[0052] Take 1 kg of garlic grains, use water to make a paste, stir and place for 30 minutes, filter the allicin aqueous solution with gauze, wash the residue twice with water, and combine the supernatant;

[0053] Extract the aqueous allicin solution twice with ethyl acetate twice the volume of the allicin aqueous solution, combine the ethyl acetate phases, and remove water with anhydrous sodium sulfate;

[0054] Add the combined ethyl acetate into the spinner bottle, control the temperature at 42°C, and spin dry the solvent to obtain allicin-containing garlic oil;

[0055] Weigh 200g of β-cyclodextrin and add 300mL of water, stir it into a slurry to obtain an aqueous solution of β-cyclodextrin; add dehydrated alcohol twice the volume of garlic oil containing allicin to the allicin-containing garlic oil, and adjust to The ethanol solution of allicin is added to the β-cyclodextrin aqueous solution, stirred evenly, and the material is ultrasonicated at room temperature for 30 mi...

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Abstract

The invention provides an ajoene microcapsule powder product and its preparation method and use. The ajoene microcapsule powder product can be processed to form a plurality of dosage forms so that an application range is widened and properties and stability are good. The preparation method comprises carrying out extraction on garlicin-containing raw materials through water, filtering the extract to obtain a garlicin aqueous solution, extracting garlicin in the garlicin aqueous solution through an organic solvent, collecting the organic solvent phase, removing water, drying the garlicin to obtain garlicin-containing garlic oil, preparing a beta-cyclodextrin aqueous solution, embedding the garlicin-containing garlic oil with the beta-cyclodextrin aqueous solution to obtain a beta-cyclodextrin suspension, drying and crushing the beta-cyclodextrin suspension, and sieving the powder to obtain the ajoene microcapsule powder product. The preparation method can be used for ajoene microcapsule powder product preparation.

Description

technical field [0001] The invention relates to a preparation method for extracting active ingredients from garlic-containing raw materials, in particular to a preparation method for ajoene microcapsule powder products, ajoene microcapsule powder products prepared by the method and applications thereof. Background technique [0002] Garlic has been on the human table for 5,000 years, and it has been a valuable resource for medicine and food since ancient times. The traditional medicine of the motherland believes that: garlic is warm in nature, pungent in taste, has the effects of lowering qi, eliminating grains, removing wind, stopping dysentery, dispelling carbuncles, and disinfecting qi. The main active ingredient in garlic is diallyl thiosulfinate (allicin), which is catalyzed by allinin, its precursor, and has the functions of antibacterial, anti-inflammatory, anti-oxidation, lowering blood fat, and lowering blood pressure. , is the main source of garlic's pungent and s...

Claims

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Application Information

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IPC IPC(8): A61K31/105C07C323/65C07C319/22A61K47/48A61K9/50A23L33/105A23P10/30A61P7/02A61P31/12A61P31/10A61P29/00
CPCA61K31/105A23V2002/00A61K9/5036C07C319/22C07C323/65A23V2200/224A23V2200/30A23V2250/212A23V2250/5112
Inventor 公丕贤
Owner 青岛博恩高科生物技术有限公司
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