253results about How to "Stable baseline" patented technology

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

The invention relates to a fingerprint map for controlling the quality and efficacy of rhizoma corydalis and preparation of the rhizoma corydalis and a preparation method of the fingerprint map. The invention discloses that the fingerprint map is one of anti-myocardial ischemic active site in the rhizoma corydalis, and the active site mainly comprises quaternary ammonium base components, wherein, columbamine, 13-methyldehydrocorydalmine, dehydrocorybulbine, palmatine, dehydrocorydaline are the main five components of quaternary ammonium base. The fingerprint map can identify the authenticity of samples and evaluate the quality and efficacy of the rhizoma corydalis or the preparation thereof, so that the quality of the rhizoma corydalis and the preparation thereof have real controllable standards, so as to ensure the product quality to be stable. The method has the advantages of being simple to operate and being accurate and reliable, which is applicable to controlling the quality and efficacy of the rhizoma corydalis and the preparation thereof.

The invention discloses an establishment method for a UPLC fingerprint spectrum of a gynecological reconstruction pill. According to the method, the authenticity and merits of the product can be quickly and accurately identified, and the advantages of being easy and convenient to use, stable, high in precision, good in reproducibility and the like are achieved; in addition, the variety and number of chemical components contained in the gynecological reconstruction pill can be comprehensively reflected, then the quality of the gynecological reconstruction pill is integrally described and evaluated, therefore, the quality and the medicine effect of the gynecological reconstruction pill can be truly combined together, illumination of the action mechanism is promoted, and a basis is provided for technology improvement and deep development of the gynecological reconstruction pill. Furthermore, the fingerprint spectrum, detected through the method, of the gynecological reconstruction pill contains relatively more chemical components and is moderate in height proportion of all characteristic peaks, stable in base line and good in separation degree, peak shape and column efficiency.

The invention discloses a canzhiling oral solution fingerprint map building method. The map includes the following steps of preparation of a test solution, preparation of a reference solution, testing through a high performance liquid chromatograph and processing of data and a map. The invention further discloses a Canzhiling oral solution fingerprint map and a method for utilizing the fingerprint map to control quality of a Canzhiling oral solution. The Canzhiling oral solution fingerprint map building method is simple in operation, stable, reliable, high in accuracy and high in separation degree, the fingerprint map is high in stability and reproducibility and large in information quantity, and the fingerprint map is adopted as a quality control means for the Canzhiling oral solution, so that one-sidedness caused by judging of overall quality of a preparation by testing one or two chemical ingredients is avoided, and probability of artificial processing in order to enabling quality to be up to standards is lowered; samples of multiple batches are analyzed systematically, so that quality of the Canzhiling oral solution can be evaluated more comprehensively and scientifically, and product quality and efficacy are guaranteed.

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

The invention provides a detection method of 1-[2-(2, 4-dimethylphenylthioalkyl)phenyl]piperazine or salt thereof. The method includes the steps of: taking a methanol solution containing 1-[2-(2, 4-dimethylphenylthioalkyl)phenyl]piperazine or salt thereof as a test solution, and performing detection according to high performance liquid chromatography conditions, which specifically includes: use of pentafluorophenyl as the filler; employment of a methanol-0.02mol.L<-1> ammonium acetate buffer solution as the mobile phase A, and taking of acetonitrile as the mobile phase B; and conducting gradient elution. The detection method has the advantages of good separation degree of active components and impurities, stable baseline, and good repeatability and stability of a sample and impurities, thus being more beneficial to quality control.

The invention discloses a detection method for atractylodes macrocephala koidz medicinal materials. The method adopts HPLC (high performance liquid chromatography) fingerprint spectrum for detection and includes the operation steps of: (1) preparing sample solution; (2) preparing reference solution; and (3) respectively and precisely absorbing the sample solution and the reference solution to inject into a liquid chromatograph so as to elute by taking an acetonitrile-water system as a flowing phase and detect at wavelengths of 248+ / -5nm. After the atractylodes macrocephala koidz medicinal materials are decocted with water, and then the HPLC fingerprint spectrum is applied for detection, so that quality of the atractylodes macrocephala koidz medicinal materials can be reflected more truly. Moreover, chromatographic conditions such as the flowing phase are selected specifically, so that chromatogram baselines are stable and convenient to integrate, resolution of characteristic peaks is good, and similarity among different medicinal materials is high. The detection method for the atractylodes macrocephala koidz medicinal materials can be effectively used for quality control of atractylodes macrocephala koidz and provides a guarantee of medication security of the atractylodes macrocephala koidz medicinal materials.

The invention relates to the technical field of chemical analysis, in particular to a method for detecting a drug and enantiomer impurities of the drug. The method is characterized in that a sample to be detected, organic amine and acyl chloride are subjected to derivatization reaction, a reaction resultant is separated through a chirality chromatographic column by the adoption of high performance liquid chromatography and detected through an ultraviolet detector, and then the content is obtained through calculation. The method is stable, practicable and easy, convenient and rapid to implement.

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stoke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

The invention provides an aboveground part extract and a detection method thereof. The extract is detected via an HPLC (High Performance Liquid Chromatography) fingerprint method. The herba houttuyniae aboveground part extract covers multi-class active components, is unambiguous is material basis, can serve as a new standard control for medicinal material quality detection, and more facilitates quality control to the herba houttuyniae aboveground part. According to the invention, the optimal detection method of the herba houttuyniae aboveground part is achieved via a comprehensively surveying sample solution preparation method and color spectrum conditions. When the detection method is applied, a base line is stable, chromatographic peak shape and resolution are favorable, and meanwhile, flavonoid and organic acid chemical compounds of the herba houttuyniae can be synchronously detected, provides a reliable method for quality detection of the herba houttuyniae aboveground part, and ensures medicinal material quality of the herba houttuyniae aboveground.

The invention relates to a design method for the formation configuration of distributed satellites with synthetic aperture radars (SAR). The method comprises the following five operation steps: step 1The invention relates to a design method for the formation configuration of distributed satellites with synthetic aperture radars (SAR). The method comprises the following five operation steps: step 1: designing the formation configuration of the distributed satellites and conforming fly-by path equations; step 2: confirming an optimal base line length range of the distributed satellites in start: designing the formation configuration of the distributed satellites and conforming fly-by path equations; step 2: confirming an optimal base line length range of the distributed satellites in starttime; step 3: confirming an optimal base line sequence of the distributed satellites in start time; step 4: confirming track parameters of the formed satellites forming a concentric circle configuratitime; step 3: confirming an optimal base line sequence of the distributed satellites in start time; step 4: confirming track parameters of the formed satellites forming a concentric circle configuration; and step 5: calculating effective base lines and vertical path base lines in a track period. The invention provides the concentric circle formation configuration, uses the optimal base line combinon; and step 5: calculating effective base lines and vertical path base lines in a track period. The invention provides the concentric circle formation configuration, uses the optimal base line combined constraint conditions of multi-base line interference SARs as design input parameters and designs a control law of radar antenna visual angles to realize that a distributed satellite SAR system caned constraint conditions of multi-base line interference SARs as design input parameters and designs a control law of radar antenna visual angles to realize that a distributed satellite SAR system cansatisfy the design requirements of the optimal base line combined constraint conditions in any time in a track operation period and a basis is provided for the distributed satellite SAR system to obt satisfy the design requirements of the optimal base line combined constraint conditions in any time in a track operation period and a basis is provided for the distributed satellite SAR system to obtain high-precision DEM products by a multi-base line interference SAR treatment method.ain high-precision DEM products by a multi-base line interference SAR treatment method.

The present invention provides a method for detecting impurities in formoterol fumarate or related preparations thereof. The method comprises a step of detecting diastereoisomer impurities (impuritiesI) in the formoterol fumarate or related preparations by using a high performance liquid chromatography method, wherein an eluent used in the high performance liquid chromatography is a system consisting of a liquid A and a liquid B, the liquid A is an ion pair reagent buffer, the liquid B is acetonitrile, and the elution mode is isocratic elution. The method of the invention has the advantages of good tolerance, long service life, the good reproducibility of a detection result, and multiple types of optional columns, and the reduction of the application cost. A measurement result obtained bythe method of the invention is accurate, and the method can be simultaneously applied to the detection of the content of diastereoisomer impurities in a formoterol fumarate crude drug and related preparations.

An anti-inflammatory tablet HPLC fingerprint construction method comprises the following steps: 1, preparing a test solution: grinding an anti-inflammatory tablet, weighing the ground tablet, placing the ground tablet in an extractor, adding petroleum ether, carrying out hot reflux extraction, removing the petroleum ether, adding methanol, carrying out ultrasonic treatment, supplementing methanol, and filtering the obtained solution; 2, preparing a reference solution: taking a chlorogenic acid reference substance, an aesculetin reference substance, a scutelloside reference substance, a linarin reference substance, a baicalein reference substance and a wogonin reference substance; and 3, determining: respectively taking the reference solution and the test solution, respectively injecting the reference solution and the test solution to a liquid chromatograph, recording the chromatogram in 120min, and processing the chromatogram through using fingerprint software to obtain the fingerprint of the anti-inflammatory tablet. The method has the advantages of establishing the common mode of the HPLC characteristic fingerprint of the anti-inflammatory tablet, calibration of 27 common peaks, effective characterization of the quality of the anti-inflammatory tablet, overcoming of unicity and one-sidedness of original quality control methods, and high application values.

The present invention relates to the technical field of analytical chemistry, and particularly relates to a nine-element wind-extinguishing particle component quantitative detection method and a fingerprint construction method. The detection method comprises taking a nine-element wind-extinguishing particle to-be-tested sample and a standard substance for HPLC detection, and obtaining nine-element wind-extinguishing particle components and contents according to HPLC detection results; wherein HPLC detection chromatographic conditions are as follows: a C18 chromatographic column is used, methanol is used as a mobile phase A, and triethylamine is used as a mobile phase B for gradient elution. The fingerprint measured by the detection method can more fully reflect nine-element wind-extinguishing particle chemical components, chromatographic peak separation is good, baseline is steady, peak forms are good, reproducibility is good, the method has good linear relationship, precision, stability and recovery rate, and can accurately detect the nine-element wind-extinguishing particle chemical component content, and the obtained control fingerprint can objectively assess the quality of the sample.