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126 results about "Phenylpiperazine" patented technology

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.

Preparation method for vortioxetine

The invention discloses a preparation method for vortioxetine. The preparation method comprises the following steps of (1) performing diazotization on a compound 4 to obtain a compound 5; (2) coupling the compound 5 and a compound 6 to obtain a compound 7; (3) deacetylating the compound 7 to obtain 1-(2-(2,4-dimethyl phenylthio)phenyl)piperazine (i.e. vortioxetine) shown in formula 8. According to the method, operation is simplified, the yield is increased, the cost is greatly reduced, and the method is more suitable for industrial expansion, and has remarkable creativity and practical application value.
Owner:HANGZHOU HEZE PHARMA TECH

H2S corrosion resistant ground gathering system corrosion inhibitor and preparation method thereof

ActiveCN102517588ANo protectionProtection no pitting noPhenylpiperazineMetallic materials
The invention discloses an H2S corrosion resistant ground gathering system corrosion inhibitor and a preparation method thereof. The H2S corrosion resistant ground gathering system corrosion inhibitor comprises the following ingredients in mass percent: 20-40% of main ingredient, N-benzyl-N '-phenylpiperazine and 60-80% of compound, wherein the compound comprises the following ingredients in masspercent: 5-15% of methoxy propyl amine, 5-15% of hydroxy ethylidene diphosphate, 5-20% of methylamine, 5-20% of emulsifying agent and 40-50% of solvent; the main ingredient, N-benzyl-N '-phenylpiperazine is prepared by N-phenylpiperazine and benzyl chloride. The corrosion inhibitor of the invention is a water-soluble corrosion inhibitor, so that the corrosion inhibitor can be extensively applied in the H2S corrosion and high mineralization water of pipelines in the ground gathering system to effectively control the H2S corrosion on the metallic materials in the ground gathering pipelines; besides, the corrosion inhibitor has the advantages of non pungent smell, little dosage, high corrosion inhibition efficiency, simple and convenient production, good water-soluble dispersibility, uniformand dense adsorption film, and non spot corrosion or pointed corrosion on material protection.
Owner:BC P INC CHINA NAT PETROLEUM CORP +1

Certain crystalline hydrates,pharmaceutical compositions thereof and methods for preparation and use thereof

Provided is at least one crystalline hydrate of (S)-[N-3-(3'-fluoro-4'-(4''-phenyl piperazinyl)) phenyl-2-oxo-5-oxazolidinyl] methyl acetamide, such as those with the following formula, wherein y is a number ranging from 1 / 12 to 1. Also provided are methods for the preparation of such crystalline hydrates, pharmaceutical compositions comprising such crystalline hydrates, and methods for their uses.
Owner:深圳沃克锂科技有限责任公司

Environment-sensitive alpha1-adrenergic receptor near infrared fluorescence ligands and application thereof

The invention relates to environment-sensitive alpha1-adrenergic receptor near infrared fluorescence ligands and an application thereof. The ligands are represented by general formula (I); and in the formula (I), R1 is a pharmacophore quinazoline or phenylpiperazine, R2 is a different substituent, X is a linker (carbon chain or triazole ring) of different types, n1 represents the carbon number and is 1-6, and X2 is an iodide or bromide ion. The molecules of the fluorescence ligands have high affinity to an alpha1-adrenergic receptor, and the fluorescence does not substantially enhance with the polarity decrease or viscosity increase of surrounding environment. When the ligand molecules are combined with the alpha1-adrenergic receptor, the molecules enter hydrophobic environment and release a strong fluorescence signal, so visualization is easily realized, and the signal to noise ratio is good. The fluorescence ligands can be used in researches of the pharmacologic and physiological characteristics of the alpha1-adrenergic receptor as a tool drug. A preparation method of like compounds has the advantages of maturation, mild reaction conditions, cheap and easily available raw materials, and convenient operation and post-treatment.
Owner:SHANDONG UNIV

Azole antifungal compound and its preparation method and application

InactiveCN103275024AStrong antifungal activity against deep fungiGood antifungal activityOrganic active ingredientsAntimycoticsPhenylpiperazineAntifungal drug
The invention provides an azole antifungal compound and its pharmaceutically acceptable salt. The structural general formula of the azole antifungal compound is shown in the specification, wherein R is selected from various aliphatic primary amine or secondary amine, aromatic primary amine or secondary amine and various substituted phenylpiperazine; the substituent group on phenyl of the substituted phenylpiperazine is hydrogen, alkyl group, halogen, cyanogroup, nitro-group, amino group or alkoxy group, is arranged at ortho, meta or para position of phenyl ring, and is monosubstituted or polysubstituted; the alkyl group is the alkyl group with 1-4 carbon atoms; the halogen is selected from F, Cl, Br or I; and the alkoxy group is selected from methoxy, ethoxy and t-butyl oxygroup. The compound provided by the invention has strong antifungal activity to deep fungi. In comparison with present antifungal drugs applied in clinic, the compound provided by the invention has advantages of high efficiency, low toxicity, wide antifungal spectrum and the like. Thus, the compound can be applied to prepare antifungal drugs. A preparation method of the compound is simple and has high yield. The prepared compound has a good antifungal effect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

N-benzylbenzamide compounds and preparation method thereof

The invention relates to N-benzylbenzamide compounds represented by formula (I), a preparation method and a medicinal use thereof, and an anti-tuberculosis medicinal composition adopting the compounds as an effective component. The N-benzylbenzamide compounds are concretely characterized in that a substituent group in the para-position of a benzyl group of the N-benzylbenzamide compounds is a nitrogen-containing heterocyclic segment; and in the formula (I), R represents a trifluoromethyl group or a nitro group, and X represents a 4-thiomorpholinyl group, an octahydro-2H-isoindole-2-yl group, an isoindoline-2-yl group, a 4-substituted piperidine-1-yl group, a (4-substituted phenyl)piperidine-1-yl group or a (4-substituted phenyl)piperazine-1-yl group.
Owner:ZHEJIANG STARRY PHARMA +1

Method for synthesizing mirtazapine

The invention discloses a method for synthesizing mirtazapine. According to the method, 2-halogenated nicotinonitrile is used as an initial compound, and 2-chloronicotinamide, 2-(4-methyl-2phenyl-1-piperazinyl)nicotinamide, 2-(4-methyl-2phenyl-1-piperazinyl)nicotinic acid, 1-(3-hydroxymethylpyridyl-2-)-4-methyl-2-phenylpiperazine and other intermediate products are sequentially synthesized to prepare the mirtazapine. Against the defects in a current mirtazapine synthesizing method, the process is improved, a new synthesizing route is designed, and a preparation method which is economical and is easy for practical operation is provided to mirtazapine synthesis. The method is suitable for large-scale industrial production.
Owner:BEIJING MEDISAN TECH +2

Surfactant for development of low-permeability oil reservoir and preparation method of surfactant

The invention discloses a surfactant for development of a low-permeability oil reservoir and a preparation method of the surfactant. The preparation method comprises the following steps: reacting 1-(4-hydroxyphenyl)piperazine with organic acid to prepare an amidation product; reacting an amidation product with ethylene oxide and propylene oxide in sequence to prepare a nonionic product containingpolyoxyethylene and polyoxypropylene chain segments; and finally, sulfonating the non-ionic product through fuming sulfuric acid to prepare the anionic / non-ionic surfactant. The surfactant has excellent dissolving, temperature-resistant and salt-resistant properties, the adsorption, interfacial tension change, wettability adjustment and other properties of the surfactant are controllable, and theself-imbibition recovery ratio of the low-permeability oil reservoir can be remarkably increased.
Owner:CHINA NAT OFFSHORE OIL CORP +1
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