The invention belongs to the technical field of building construction, and discloses a prefabricated prestressed concrete filled steel tubular column and a construction method. The prefabricated prestressed concrete filled steel tubular column is mainly composed of steel pipes, an oil separant, positioning frames, concrete, steel formworks, bolts, column top connecting pieces and column foot connecting pieces, wherein the steel formworks are located outside the whole device, the inner wall of the outer steel pipe is coated with the oil separant, and the concrete is poured, so that the steel pipe and the concrete are kept in an isolated state; the column top connecting pieces and the column foot connecting pieces are located on the whole column top and the whole column foot respectively and play a role of a support, and the positioning frames are divided into an upper positioning frame and a lower positioning frame. The prestressed concrete filled steel tubular column manufactured through the construction method of the prefabricated prestressed concrete filled steel tubular column is simple in structure, compressive pre-stress is applied to internal concrete in advance, and therefore, the compressive strength of the concrete is improved, the restraining effect of the steel pipe can be achieved at the initial loading stage, and the stress performance is good.