55results about How to "Reduced fertility" patented technology

Methods for increasing and decreasing male fertility using selective 11β-HSD1-dehydrogenase, 11β-HSD1-reductase and 11β-HSD2 dehydrogenase modulating compounds are described.

Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.

Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.

The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.

The invention relates to a seeding medium made of vinasse methane-sludge and a preparation method thereof, not only solving the problem of environment contamination caused by vinasse methane-sludge, but also effectively utilizing vinasse methane-sludge. The seeding medium comprises fresh sludge containing 90 percent of water after methane generated from vinasse in a methane tank, accessories, ferment strain I and ferment strain II, wherein the accessories comprise grass peat, vermiculite and perlite; the ferment strain I comprises saccharomycetes, lactobacillus, high-temperature actinomycetes and bacillus; and the ferment strain II comprises photosynthetic bacteria, lactobacillus, bacillus, saccharomycetes, actinomycetes and terrestrial cyanobacteria. The preparation method comprises the following steps of preparing fresh sludge, dehydrating, adding the ferment strain I for fermentation, adding the ferment strain II for secondary fermentation, air drying, adding accessories, crushing, screening and packing. The vinasse methane-sludge contains 40 to 50 percent of organic matter and 4.3 percent of available nitrogen (N), phosphorus (P) and kalium (K). The seeding medium made of vinasse methane-sludge has better hydrophilicity, and seeding can be carried out after loading the dry seeding medium and spraying water, thus saving both labor and time.

A method and a corresponding composition of matter for diagnosing or increasing the fertility of semen is described. The method involves measuring DNase activity in a semen sample, wherein greater DNase activity in the semen sample indicates increased fertility of the semen sample. Also described is a corresponding composition for storing and increasing the fertility of semen. The composition includes a diluent and an amount of exogenous DNase and-or fertility-associated antigen (FAA) disposed in the diluent. The amount of the exogenous DNase and / or FAA added to the diluent is effective to increase fertility of the semen stored in the composition.

The invention discloses a modified bismaleimide resin and a preparation method thereof. The method comprises the following steps: acidating biomass-based 2, 5-furandicarboxylic acid and thionyl chloride under the condition of using N,N-dimethyl formamide as the catalyst to obtain 2,5-furandicarbonyl dichloride, respectively dissolving the 2,5-furandicarbonyl dichloride and biomass-based eugenol in dichloromethane, and carrying out an esterification reaction under the condition of tertiary amine to obtain bis(4-allyl-2-methoxyphenyl)furan-2,5-dicarboxylic ester based on total biomass, and using the bis(4-allyl-2-methoxyphenyl)furan-2,5-dicarboxylic ester to prepare the modified bismaleimide resin. The modified bismaleimide resin prepared by the invention has excellent thermal performance and rigidity; and the preparation method adopts the biomass-based 2,5-furandicarboxylic acid and the biomass-based eugenol, the raw materials are green, environment-friendly and renewable, and the production process is simple, and the resin has a wide application prospect in the fields of aerospace, electronic information, electrical insulation and the like.

The invention provides methods for decreasing lignin content and for increasing the level of fermentable carbohydrates in plants by down-regulation of the NST transcription factor. Nucleic acid constructs for down-regulation of NST are described. Transgenic plants are provided that comprise reduced lignin content. Plants described herein may be used, for example, as improved biofuel feedstock and as highly digestible forage crops. Methods for processing plant tissue and for producing ethanol by utilizing such plants are also provided.

Novel tricyclic cannabinoid compounds are presented. Some of these compounds exhibit fluorescence properties. The fluorescent cannabinoid compounds are typically endogenously fluorescent. Some of these compounds, when administered in a therapeutically effective amount to an individual or animal, result in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response useful to treat a number of physiological conditions.

The invention discloses an ex-situ oil thermal-desorption method. According to the invention, soil to be repaired is preheated by using heat of bottom residues of a biomass circulating fluidized bed boiler through a heat pipe heat exchange manner, then, pollutants in the soil are desorbed by using heat of circulating ash of the biomass circulating fluidized bed boiler through a direct heat exchange manner, meanwhile, the fertility of repaired soil is improved by using active ingredients in the circulating ash, and gaseous pollutants generated by desorption are introduced into the boiler to be incinerated and decomposed. On the basis of waste heat of the bottom residues of the boiler, thermal desorption of soil is realized, meanwhile, the fertility of soil is improved by blending active ingredients, and volatile pollutants generated by desorption are conveyed into the boiler to be incinerated directly, so that secondary pollution is avoided.

Novel tricyclic cannabinoid compounds are presented. Some of these compounds exhibit fluorescence properties. The fluorescent cannabinoid compounds are typically endogenously fluorescent. Some of these compounds, when administered in a therapeutically effective amount to an individual or animal, result in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response useful to treat a number of physiological conditions.

The invention discloses an ex-situ soil thermal desorption device. Soil to be repaired is preheated through heat of bottom residues of a biomass circulating fluidized bed boiler through a heat pipe heat exchange manner; then a direct heat exchange manner is used for desorbing pollutants in soil through heat of circulating ash of the biomass circulating fluidized bed boiler; and meanwhile fertility of the repaired soil is improved through active ingredients in the circulating ash, and gaseous pollutants generated through desorption are introduced into the boiler to be incinerated and decomposed. The device achieving the method comprises a slag conveying room, a first cold residue room, a second cold residue room, a third cold residue room, an inertia separating room, a preheating room, an analyzing room and a heat regeneration room. According to the ex-situ soil thermal desorption device, thermal desorption of the soil is achieved based on waste heat of the bottom residues of the boiler, meanwhile, fertilizer of the soil is improved by mixing active ingredients, volatile pollutants generated through desorption are sent into the boiler to be directly incinerated, and secondary pollution is avoided.

Provided is a real-time continuous detection device for detecting an analyte in a sample including: a sample inflow channel; a sample assay site; and a sample outflow channel, wherein the sample assay site includes a reversible capturing recognizing component and a sensor which detects a signal generated from a binding body of the analyte and the reversible capturing recognizing component. According to the real-time continuous detection device, it is possible to measure a change in concentration of the analyte in real time by continuously recycling the reversible capturing recognizing component. The real-time continuous detection device can be used to detect or assay living organism metabolites, a protein, a hormone, a nucleic acid, a cell, a food test material, an environment contaminant, national-defense chemical, biological and radiological test materials, or the like. Accordingly, the real-time continuous detection device can be applied to medical, public health, national defense, environment, food, veterinary, and biotechnology industries.

A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopolesis regulating activity, tissue generation / regeneration activity, activin / inhibin activity, chemotactic / chemokinetic activity, hemostatic and thrombolytic activity, and receptor / ligand activity, therefore, they are expected to be useful for prevention and / or treatment of various diseases.

The present invention provides methods for detecting epigenetic, multigenerational DNA alterations caused by toxicants such as endocrine disruptor agents in a subject. The practice of the present invention can be used to diagnose and / or treat a subject having the identified DNA alterations by developing therapeutics, to prevent or delay the onset of associated diseases and / or dysfunctions.

The present invention relates to methods of increasing likelihood of conception, treatment of low fecundity and / or providing menstrual cycle control without suppressing ovulation in a female comprising administering an effective dose of at least one estrogen and at least one progestin within a treatment period of at least 21 days to 35 days or multiple periods thereof. Furthermore, the invention relates to the combination of at least one estrogen and at least one progestin for the preparation of a medicament to be used in the abovementioned indications. A pharmaceutical kit, according to the invention, comprises 21 to 35 dosage units or a multiple of 21 to 35 dosage units, wherein a first section comprises at most 21 dosage units of at least one estrogen; and a second section comprises from 2 to 34 dosage units of at least one estrogen and from 2 to 34 dosage units of at least one progestin or comprises from 2 to 34 dosage units of at least one estrogen and at least one progestin provided that in each dosage unit containing a progestin or a progestin and an estrogen the progestin is in a non-ovulation inhibiting amount; and and optionally a third section comprises at most 10 dosages of a pharmaceutically acceptable placebo or a blank.

The invention discloses an aquatic plant recycling method. The method comprises the following steps: 1, producing a botanical feed: 1-1) preprocessing a raw material; 1-2) producing a feed; and 1-3) nursing livestock and poultry; 2, producing biomass energy: 2-1) carrying out retting pretreatment; 2-2) mixing raw materials; 2-3) carrying out dry anaerobic fermentation; and 2-4) carrying out biogas comprehensive utilization; and 3, producing a high-efficiency multi-bacterial composite ecologic fertilizer: 3-1) preparing raw materials; 3-2) mixing and proportioning the raw materials; 3-3) carrying out high-temperature aerobic composting; 3-4) carrying out medium-temperature aerobic composting; and 3-5) mechanically granulating the obtained product, and packaging the granulated product. Aquatic plant wastes are adopted as the raw material, so the environment problems brought by landfill, onsite stacking or burning and other common aquatic plant waste disposing means are solved, the aquatic plant recycling mode is enriched, and values of aquatic plants are fully shown.

The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production.

The present invention relates to treatments and therapies for anemia conditions and diseases of the blood, and more particular is a therapy for the acute and chronic treatment of sickle cell diseases and thalassemia by administration of pyridoxamine, or a pharmaceutically acceptable salt thereof, optionally in combination with an additional bioactive agent.

The invention provides a concealed conduit system, a paving method and an application thereof. The system comprises a concealed conduit and water collecting wells; the concealed conduit comprises a water exhausting conduit and a water collecting conduit, and the water exhausting conduit and the water collecting conduit are arranged in a vertically crossed mode or in obliquely crossed herringbone mode; the water collecting wells are sequentially arranged in the direction of the water collecting conduit; and the water exhausting conduit is provided with holes, and the water collecting conduit isnot provided with a hole. The concealed conduit system is reasonably arranged, a proper eluting agent is added, so that heavy metals in the polluted soil can be in situ and efficiently removed, the removal efficiency of the heavy metals such as lead, cadmium and zinc can reach 50-90%, and the soil treatment effect is good; the system belongs to an environment-friendly treatment mode, so that thedamage to the soil is small, the soil fertility is not reduced; and the system is suitable for treating the soil polluted by the various kinds of the heavy metals, the operation cost is low, and the economical efficiency is high.

The invention provides a rice doubled haploid breeding method based on a haploid inducer and belongs to the technical field of agriculture. According to the method herein, a rice three-line maintainermaterial is hybridized with a rice material having a dominant red rice gene, a red rice maintainer carrying the dominant red rice gene are attained by screening, the red rice maintainer is subjectedto chemical directional induction, a mutant with a centromere mutant gene function is attained by screening, and the mutant is hybridized with a rice three-line sterile line to obtain a maintainer andsterile line carrying the red rice gene and centromere mutant gene; a hybrid F1 prepared according to breeding targets is hybridized with a red rice haploid induced sterile line before colorless-coathybrid seeds are retained; the colorless hybrid seeds are treated with colchicine to obtain a diploid material, namely, a novel line is formed. The rice doubled haploid breeding method based on the haploid inducer allows a homozygous gene to be attained quickly, helps overcome the defect segregative generations in traditional breeding are long, and is applicable to rice breeding.