The product provides a cefixime orally disintegrating tablet. The cefixime orally disintegrating tablet contains cefixime, microcrystalline cellulose, low-substituted hydroxy propyl cellulose, crosslinking polyvinylpyrrolidone, mannitol, aspartame, magnesium stearate, etc., wherein each tablet contains 100mg of cefixime. The cefixime orally disintegrating tablet of the invention is convenient for taking, can be taken without water, is fast disintegrated in an oral cavity, and has no delay phenomenon in an esophagus. Greatly convenience is provided for children, the elderly, patients with mental diseases, and bedridden patients who are difficult to move. Characteristic of fast disintegration in the oral cavity makes a drug absorption area increase, and the cefixime orally disintegrating tablet has advantage of easy and rapid absorption, small irritation on an alimentary canal mucous membrane and high bioavailability. The cefixime orally disintegrating tablet is convenient for carrying and taking. Compared with a common solid oral preparation, the cefixime orally disintegrating tablet can be fast absorbed, provides greatly convenience for patients, greatly raises treatment compliance, and has a good clinic application prospect. The cefixime orally disintegrating tablet of the invention has a simple preparation method, is suitable for industrialization production, and has a great application value.