A simple and efficient programmable universal switch board relates to the technical field of electronic products and comprises a power supply circuit, a USB interface circuit, a serial port circuit, an MCU circuit, a drive circuit and a relay array, wherein the USB interface circuit, the serial port circuit are both connected with the MCU circuit; the MCU circuit is connected with the drive circuit through a SPI IN interface; the drive circuit is respectively connected with an SPI OUT interface and the relay array; the power supply circuit is connected with the USB interface circuit, the serial port circuit, the MCU circuit, the drive circuit and the relay array to supply power to the USB interface circuit, the serial port circuit, the MCU circuit, the drive circuit and the relay array. Compared with the traditional PCI or PXI bus, the simple and efficient programmable universal switch board has the advantages of simple structure, light weight, small size and the like and can be used independently or expanded through cascade connection.