60results about How to "Intolerance" patented technology

The invention belongs to the field of feed additive and discloses a bacillus subtilis and the application thereof in biological feed additives. The bacillus subtilis HF-A2 related in the invention ispreserved in Common Microorganism Center, China Committee of Culture Collection for Microorganisms on August 19th, 2009, with a preservation number of CGMCC No. 3241. The bacillus subtilis HF-A2 (CGMCC No. 3241) is obtained by selecting content matters collected from gastrointestinal parts of a healthy anthony pig, which are close to mucosa. The strain of the bacillus subtilis has a strong capability in resisting the physical environment of the alimentary canal and resisting processing, performs well in inhibiting bacteria and deodorization and is safe and reliable. The biological feed additives prepared from the strain can inhibit harmful microorganisms in the alimentary canal, replace antibiotics and chemical drugs, remarkably enhance the immunity of livestock and poultry, promote the healthy growth of the animals, reduce the odor of wastes and purify the raising environment.

A Chinese medicine for treating hypertension is prepared from 30 Chinese-medicinal materials including gingko leaf, epimedium, haw, leech, etc.

The invention discloses the application of koumine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the koumine on chronic pains of animals prove that the koumine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the koumine is much higher than that of the total alkaloids of gelsemium, the koumine possibly has no tolerance, no addiction and little side effect, which indicates that the koumine has potent and low-toxicity analgesic effect, the mechanism of action of the koumine is possibly different from those of clinically common opium analgesics or aspirin analgesics, the koumine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and the like, has no tolerance and addiction and little side effect, thus the koumine has bright industrialization prospect.

The invention discloses a skin wound dressing with the antimicrobial property and a preparation method of the skin wound dressing, belonging to the technical field of biomedical engineering. The skin wound dressing provided by the invention is of the spongy porous membrane structure, specifically, a sodium alginate fibrous membrane is prepared by taking sodium alginate as a base material through a freeze drying method, then biological antimicrobial peptide Cys-KR12 is fixed to the fibrous membrane through a surface finishing method, and thus the skin wound dressing is prepared. The skin wound dressing prepared by adopting the method provided by the invention is simple in preparation method and easily available in raw materials, the defects that the drug tolerance is generated, the functions are single, and the like after the existing antimicrobial dressing is used for a long term are overcome, and the skin wound dressing provided by the invention has low immunogenicity, good biocompatibility, good antimicrobial property and good induction repairing function, can promote the healing of the wound surface and the growth of epithelial cells, and is beneficial for the re-epithelialization of the wound surface.

The invention discloses a five-step early feeding method for a piglet, and belongs to the field of domestic livestock breeding. The method mainly comprises the following steps that firstly, fodder calling is carried out, when the piglet is born for 2-3 days, the fodder calling is carried out through pig milk powder; secondly, groove teaching is carried out, when the piglet reaches 7-8 days old, the groove teaching is carried out through groove teaching materials and the pig milk powder; thirdly, weaning is carried out, when the piglet is 23-28 days old, the daily food consumption of the piglet reaches more than 600 g or the weight of the piglet reaches more than 10 KG, the weaning is carried out on the piglet; fourthly, fodder changing is carried out, earlier-stage nursing fodder, later-stage nursing fodder, piglet complete formula fodder, middle pig complete formula fodder and big pig complete formula fodder are sequentially carried out on the weaning piglet until the piglet is in slaughter. The method is simple, the use is convenient, the early fodder calling and the early groove teaching are carried out on the piglet so that the early meaning and the early fodder changing are carried out on the piglet, and the early slaughter can be carried out on the piglet. The method is mainly used for feeding of the piglet.

The invention discloses a compound gardenia oil soft capsule and a method for preparing the same. The gardenia oil soft capsule is used for treating insomnia and consists of a content and rubber sheet, wherein the content consists of clear spina date seed oil, clear semen boitae oil and clear gardenia oil according to a mass ratio of 3:2-3:1-1.5, and the rubber sheet consists of a rubber material, humectant, water and antiseptic according to a mass ratio of 10:4-6:7-14:0.005. The clear spina date seed oil, the clear semen boitae oil and the clear gardenia oil are mixed uniformly to form the content; the water is heated and added sequentially with the humectant, the antiseptic and the rubber material to form a gum-solution; the content and the gum-solution are pressed by the prior pressing method so as to be formed; and after post treatment, the compound gardenia oil soft capsule is obtained. The compound gardenia oil soft capsule is reasonable in formula, has a sedative-hypnotic function which can be enhanced by long drug application time, is free from tolerance and suitable to be used for treating insomnia, and can relieve physical fatigue.

The invention relates to the field of hand sanitizers, in particular to a silver nanowire wash-free antibacterial hand sanitizer. The silver nanowire wash-free antibacterial hand sanitizer is preparedby mixing the following raw materials in percentage by weight: 10-75% of ethanol, 0.1-0.5% of a surfactant, 0.1-1% of a thickener, 1-5% of a humectant, 1-25% of a silver nanowire diluent, 0.01-0.5% of a pH regulator, 0.01-2% of tetrahydromethylpyrimidine carboxylic acid, 0.01-3% of a fragrance extracting solution, 0.1-2% of vitamin E and the balance of deionized water. According to the invention,the unique antibacterial effect of the nano-silver is utilized to effectively sterilize; and meanwhile, compared with a traditional silver antibacterial agent, the nano-silver wire diluent has extremely large specific surface area, is easier to be in close contact with pathogenic microorganisms, and has a more obvious antibacterial effect; meanwhile, tetrahydromethylpyrimidine carboxylic acid with bioactivity is added, so that hands are not hurt while bacteria are effectively inhibited and killed; the wash-free function is achieved, and water resources are saved.

The invention discloses the application of koumine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the koumine on chronic pains of animals prove that the koumine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the koumine is much higher than that of the total alkaloids of gelsemium, the koumine possibly has no tolerance, no addiction and little side effect, which indicates that the koumine has potent and low-toxicity analgesic effect, the mechanism of action of the koumine is possibly different from those of clinically commonopium analgesics or aspirin analgesics. The koumine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains, have no serious disadvantages of the clinically common analgesics, and can be developed into a novel analgesic which has potent analgesic effect on treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain, and the like, has no tolerance and addiction and little side effect, thus the koumine has bright industrialization prospect.

The invention discloses a Chinese herba preparation for treating depression. The Chinese herba preparation comprises 23 types of Chinese herbal medicine such as folia perillae acutae, rehmannia glutinosa, schisandra chinensis, lotus plumule, astragalus membranaceus, polygala tenuifolia, cornus officinalis, peony tree root bark, codonopsis pilosula and elecampane. According to the Chinese herba preparation, the composition and medicine compatibility are precise and reasonable, the therapeutic dosage is low, no toxic and side effect exists, and the preparation has a good therapeutic effect on the depression caused by qi stagnation due to liver depression, phlegm qi depression, heart-spleen deficiency, liver and renal weakness, heart-lung yin deficiency and the like. The traditional Chinese medicine is low in price, easy to prepare, definite in therapeutic effect, free of toxic and side effects, applicable to depression patients of different genders and age groups and mainly used for treating mild and medium depression and woman perimenopause syndrome and climacteric syndrome.

The invention relates to a mask which is prepared from the following raw materials in parts by weight: 10-25 parts of water, 5-15 parts of propylene glycol, 3-7 parts of xanthan gum, 2-5 parts of PEG-40 hydrogenated castor oil, 5-10 parts of phyllostachys bambusoides root and stem extract, 5-10 parts of aloe extract, 5-10 parts of chamomile flower extract, 3-6 parts of PG-propyl methylsilanediol, 7-13 parts of cucumber extract, 1-4 parts of bisabolol, 3-6 parts of dipotassium glycyrrhizinate, 1-5 parts of vitamin E, 0.5-0.8 part of gold, 7-15 parts of hyaluronic acid, 1-4 parts of phenoxyethanol, 0.9-1.3 parts of dipalmityl hydroxyproline, 3-7 parts of collagen, 1-4 parts of hyaluronic acid and 0.7-3 parts of hexapeptide. The invention also provides a preparation method of the mask. The mask provided by the invention has very good moisturizing and water-replenishing and whitening effects to skin.

The invention belongs to the field of skin-care products, and provides a whitening, acne-removing, blackhead-removing and anti-aging composition, and an application and a preparation thereof. The composition provided by the invention has whitening, acne-removing, blackhead-removing and anti-aging efffects, can inhibit the expression of inflammatory factors, namely IL-1 and TNF-a at the same time,reduces the effect of androgen dihydrotestosterone, and has the advantages of no drug resistance and no side effect compared with hormone for treatment.

The invention discloses the application of kelesin A, kelesin, and 1-methoxygerisine in the preparation of drugs for treating anxiety, especially the kelesin alkaloid monomer kelesin A as the only active ingredient or its pharmaceutical preparations. The application of above acceptable salt in the preparation of medicine for treating anxiety disorder; the application of kinesin alkaloid monomer kelezin or its pharmaceutically acceptable salt as the only active ingredient in the preparation of medicine for treating anxiety disorder; as the only active ingredient The application of the geskin alkaloid monomer 1-methoxygesine or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating anxiety; Alkaloids can play a significant role in mouse anxiety at a dose much lower than poisoning, significantly expand the safe treatment window, have no tolerance, addiction and small side effects, and are more suitable for preparation and treatment than total alkaloids Anxiety medication.

The invention discloses a traditional Chinese medicine composition for skin diseases as well as a preparation, a preparation method and use of the traditional Chinese medicine composition. The composition contains the following components in parts by weight: 2-6 parts of cortex pseudolaricis, 2-5 parts of cortex dictamni, 5-10 parts of fructus kochiae, 2-4 parts of radix sophorae flavescentis, 4-8parts of rheum officinale, 5-6 parts of fructus cnidii and 3-5 parts of borneol. The invention further provides the preparation, the preparation method and the use of the traditional Chinese medicinecomposition. The preparation is a spray. The preparation method comprises the steps of weighing the drugs in proportion, respectively drying the drugs, grinding and crushing, soaking the drugs into baijiu with alcoholic strength of 50 degrees for 1 month, and using the mixture as the spray. The traditional Chinese medicine composition provided by the invention has the characteristics that the prescription is reasonable, the use amount is small, the effect is remarkable, the composition has no toxic and side effects, can take effect rapidly and is capable of relieve itching, diminishing swelling, clearing damp and expelling toxin, the skin diseases do not easily relapse, and the like.

The invention discloses the application of gelsenicine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the gelsenicine on chronic pains of animals prove that the gelsenicine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsenicine is much higher than that of the total alkaloids of gelsemium, the gelsenicine possibly has no tolerance, no addiction and little side effect, which indicates that the gelsenicine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsenicine is possibly different from those of the clinically common opium analgesics or aspirin analgesics, the gelsenicine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsenicine has bright industrialization prospect.

The invention discloses a Chinese medicinal preparation for treating the diabetes and a preparation method. The Chinese medicinal preparation comprises 24 traditional Chinese medicines: ginseng, prepared rhizome of rehmannia, poria cocos, bighead atractylodes rhizome, astragalus mongholicus, yam, fructus corni, the root bark of the peony tree, the root of red-rooted salvia, the rhizome of oriental water plantain, the fruit of Chinese magnoliavine, red flower, eucommia ulmoides, cinnamomum cassia, the rhizome of Chinese goldthread, fingered citron, liquorice and the like. The preparation method of the Chinese medicinal preparation is simple, safe and reliable; the formula of the Chinese medicinal preparation is reasonable in compatibility; the Chinese medicinal preparation can be used for reinforcing both qi and yin, clearing away heat, moistening dryness, promoting salivation, activating blood, dispersing blood stasis, relieving itching, and eliminating pathogenic mechanisms, such as kidney yang exhaustion, endogenous dryness, phlegmatic hygrosis blood stasis and the like, caused by qi and yin deficiency, and can keep metabolic balance of a body and eliminate fatigue weakness, polydipsia, rapid digestion of food and polyorexia and symptoms of peripheral circulation disturbance, fundus hemorrhage and skin itch.

The invention belongs to the field of sustained-release drugs, particularly relates to a nisoldipine sustained-release dropping pill and the preparation method thereof, and aims to supplement the deficiency of the prior art and provide a sustained-release nisoldipine dropping pill formulation. The sustained-release nisoldipine dropping pill is prepared by adding stabilize Vitamin E and hydrophobic framework ingredients to guarantee no occurrence of an obvious change related to the substance content for the drug during the effective storage period and has the advantages of full release, controllable release time and high bioavailability simultaneously. The sustained-release nisoldipine dropping pill is suitable for clinical and family use.

The invention discloses an application of koumine and koumine homolog in the preparation of medicines for treating diabetic complications. The koumine is high in therapeutic index, the therapeutic index of the koumine for treating the pain hypersensitivity of diabetic rats is estimated to reach 4762, the koumine can be used for obviously improving the neuropathy of the diabetic rats, the details are explained in the embodiment 1, and the koumine is large in safe therapeutic window and suitable for the preparation of the medicines for treating the diabetic complications, is likely to have no tolerance or addiction, and has low side effects, and therefore, the koumine has potentially great economic effect. The koumine and the koumine homolog or pharmaceutically acceptable salts of the koumine can be applied to the preparation of the medicines for treating the diabetic complications, have no disadvantages of two types of clinically frequently-used medicines for treating the diabetic complications, are developed and researched according to national specifications about innovative drug examination and approval and are expected to be prepared into the novel national class-1 medicines for treating the diabetic complications which are capable of effectively treating the diabetic complications, have small side effects, clear industrialization prospect, no tolerance and no addiction and possess the national proprietary intellectual property rights.

The invention relates to a portable intelligent wireless sound wave sound moxibustion collateral channel dredging life-preserving physiotherapy instrument which comprises a shell (1), and a sound wavegenerator (12), a power supply (17) and a control circuit board (8) fixed in the shell (1), wherein a plurality of horn holes (2) corresponding to the sound wave generating head (12) are formed in one side of the shell (1); a MCU (11) is arranged on the control circuit board (8), the MCU (11) is connected to the sound wave generator (12) through a sound wave generating circuit, and the control circuit board (8) is connected to a sound wave remote control (16) through a wireless communication module to achieve wireless control. Self-power supply and self-sound generation of the sound wave generating head (12) are achieved. In addition, the sound wave remote control (16) can send wireless signals to the sound wave head according to a user button, so that the instrument is simple and convenient to operate, is portable and miniature and is more convenient to use. The sound wave generating head (12) can form compound waves, so that the portable intelligent wireless sound wave sound moxibustion collateral channel dredging life-preserving physiotherapy instrument is non-tolerant and effective for a long time.

The invention discloses an application of short peptide in the preparation of a product with a morphine tolerance eliminating effect. Researches find that short peptide P10581 can basically and completely turn over an inflammatory pain threshold value induced by carrageenan, and the analgesic effect lasts for more than 12 hours, which indicates that short peptide P10581 has no tolerance to the analgesic effect of mechanical pain, and the tolerance of the analgesic effect of morphine can also be eliminated by the low-dose synthetic short peptide P10581.

The invention provides a traditional Chinese medicine for treating diabetes. The traditional Chinese medicine for treating diabetes comprises the following raw materials in parts by weight: 4-8 parts of panax ginseng, 2-7 parts of ephedra alkaloid, 2-5 parts of typhae pollen flavone, 2-5 parts of pubescent angelica roots, 4-8 parts of beta-eucalyptus leaf oleyl alcohol, 3-9 parts of pternopetalum roots, 3-9 parts of kudzuvine roots, 4-8 parts of rhizoma anemarrhenae, 4-8 parts of grossy privet fruit, 5-10 parts of herba ecliptae, 5-9 parts of stir-fried atractylodes macrocephala, 2-5 parts of peach kernels, 5-9 parts of tree peony bark, 3-6 parts of radix cyathulae, 3-6 parts of burdock, 4-8 parts of figwort roots, 3-6 parts of cortex lycii radicis and 2-7 parts of leonurus. The traditional Chinese medicine is simple and unique in formula and preparation method.

The invention belongs to the field of traditional Chinese medicine, and specifically relates to a composition for treating acne and use thereof. The composition is prepared from the following components in parts by weight: 10-20 parts of Japanese thistle herbor root, 3-12 parts of spreading hedyotis herb, 10-20 parts of honeysuckle flower, 9-15 parts of Mongolian dandelion herb, 9-15 parts of dahurian patrinia herb, and 3-9 parts of rhizome of henon bamboo shoot. The medicine can significantly ameliorate swelling of rabbit's acne, inhibit expression of inflammatory factors IL-1a and TNF-a, and reduce the effect of male sex hormone dihydrotestosterone, and has the advantages of no drug resistance and no side effect when compared to hormonotherapy.

The present invention discloses a compound feed additive for improving piglet production performance and relates to the technical field of breeding. The compound feed additive is prepared by fermenting traditional Chinese medicine superfine powder with probiotics; and the traditional Chinese medicine superfine powder comprises the following traditional Chinese medicines in parts by weight: 15-25 parts of radix astragali, 15-25 parts of haws, 12-18 parts of fried bighead atractylodes rhizome, 12-18 parts of dried orange peels, 15-20 parts of cortex magnoliae officinalis, 15-20 parts of fringedpink and 10-15 parts of honey-fried licorice root. The present invention also provides a preparation method and an application of the compound feed additive. The used compound feed additive can greatly improve immunity and resistance of bred animals, reduces incidence, thus improves production performance, is also a pure natural preparation, has no tolerance, has a long-acting effect, is stable inquality and low in cost, can replace uses of anti-microorganism drug feed additives and chemically synthesized growth promoters, and is safer and more environment-friendly.

The invention provides an application of a drug composition in the preparation of drugs for preventing salmonella infection in laying hens, improving egg laying performance of the laying hens, reducing the amount of salmonella in shells and contents of eggs and improving quality of the eggs of the laying hens. The drug composition comprises, by weight, 20-50 parts of gallnut tannic acid and 10-30parts of glycine. The drug composition has the advantages of green safety and no tolerance by taking 'source conditioning' as the core; replacing antibiotics, the drug composition can effectively inhibit and kill salmonella, eliminate endotoxemia caused by bacterial death and release of endotoxin, adjust the body's immune defense, purify salmonella from the laying hens, reduce horizontal spread ofsalmonella and egg-borne contamination caused by potential endogenous displacement of chickens, improve egg laying performance and the quality of the eggs and effectively avoid food safety problems caused by the egg-derived salmonella.

The invention discloses the application of gelsemine to the preparation of medicine for treating chronic pains and belongs to the application of gelsemium alkaloid monomer, The analgesic experiments of the gelsemine on chronic pains of animals prove that the gelsemine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsemine is much higher than that of the total alkaloids of gelsemium, the gelsemine possibly has no tolerance, no addiction and little side effect, which indicates that the gelsemine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsemine is possibly different from those of the clinically common opium analgesics or aspirin analgesics, the gelsemine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsemine has bright industrialization prospect.

The invention relates to a pain easing medicine for cancer pain. The ingredients of the pain easing medicine are: zhichuanwu 39-58, zhicaowu 39-58, scorpion 1.6-2.4 and chlorpromazine hydrochloride 0.5-0.7. The invention has no tolerance and addict, and the easing effect is good.

The invention discloses a traditional Chinese medicine for treating diabetes. The traditional Chinese medicine is prepared from, by weight, 15-20 parts of mulberry leaves, 15-20 parts of cortex eucommiae, 15-20 parts of liquorice, 15-20 parts of radix trichosanthis, 10-12 parts of leeches, 10-12 parts of pseudo-ginseng, 10-12 parts of radix paeoniae alba, 5-8 parts of radix panacis quinquefolii, 5-8 parts of stiff silkworms, 5-8 parts of South dodder seeds and 1.5-2 parts of rhizoma coptidis, wherein the parts by weight of the mulberry leaves, cortex eucommiae and liquorice and radix trichosanthis are same, and the parts by weight of the leeches, pseudo-ginseng and radix paeoniae alba are same. The traditional Chinese medicine for treating the diabetes has the advantages that the formula is unique, the medicinal materials are easy to purchase and lower in cost, and has no toxic and side effects on the human body, no tolerance and a remarkable blood sugar lowering effect.