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Skin wound dressing with antimicrobial property and preparation method of skin wound dressing

A skin wound and performance technology, applied in the field of biomedical engineering, can solve the problems of single function, low compatibility, and no function of inducing tissue regeneration, and achieve the effects of simple process, long antibacterial time, and favorable re-epithelialization.

Active Publication Date: 2017-03-22
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a skin wound dressing with antibacterial properties and a preparation method thereof for the existing antibacterial dressings, which have low biocompatibility, long-term use will produce drug resistance, single function, and do not have the function of inducing tissue regeneration.

Method used

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  • Skin wound dressing with antimicrobial property and preparation method of skin wound dressing
  • Skin wound dressing with antimicrobial property and preparation method of skin wound dressing

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Effect test

Embodiment 1

[0032] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.1, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

Embodiment 2

[0034] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.25, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

Embodiment 3

[0036] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.5, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

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Abstract

The invention discloses a skin wound dressing with the antimicrobial property and a preparation method of the skin wound dressing, belonging to the technical field of biomedical engineering. The skin wound dressing provided by the invention is of the spongy porous membrane structure, specifically, a sodium alginate fibrous membrane is prepared by taking sodium alginate as a base material through a freeze drying method, then biological antimicrobial peptide Cys-KR12 is fixed to the fibrous membrane through a surface finishing method, and thus the skin wound dressing is prepared. The skin wound dressing prepared by adopting the method provided by the invention is simple in preparation method and easily available in raw materials, the defects that the drug tolerance is generated, the functions are single, and the like after the existing antimicrobial dressing is used for a long term are overcome, and the skin wound dressing provided by the invention has low immunogenicity, good biocompatibility, good antimicrobial property and good induction repairing function, can promote the healing of the wound surface and the growth of epithelial cells, and is beneficial for the re-epithelialization of the wound surface.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a skin wound dressing with antibacterial properties and a preparation method thereof. Background technique [0002] The skin is the barrier between the human body and the external environment, protecting various tissues and organs in the body from external physical, mechanical, chemical and pathogenic microorganisms. When the skin is damaged, if it cannot heal in time, the surface of the wound should be covered with dressing in time. Infection is one of the most common complications in the field of burn wound care, which will lead to a large amount of exudate in the wound, decompose extracellular matrix proteins and various growth factors, hinder epidermal regeneration and wound closure, thereby significantly affecting the recovery process, and even May cause death in burn victims. The therapy of systemic application of antibiotics often does not reach the effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44A61L15/40
CPCA61L15/28A61L15/32A61L15/40A61L15/44A61L2300/232A61L2300/252A61L2300/404C08L5/04C08L89/00
Inventor 卢亢陈锦涛陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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