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Applications of koumine in preparing medicament for treating chronic ache

A technology for chronic pain and glucosamine, which is applied to the application field of glucosinolate in the preparation of drugs for treating chronic pain, and achieves the effects of effective chronic pain, clear industrialization prospects, and strong analgesic efficacy.

Active Publication Date: 2008-12-17
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature and patent reports about the anti-chronic pain effect and possible use of kelezin

Method used

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  • Applications of koumine in preparing medicament for treating chronic ache
  • Applications of koumine in preparing medicament for treating chronic ache
  • Applications of koumine in preparing medicament for treating chronic ache

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Analgesic effect of kelezin on formalin-induced chronic pain in mice administered subcutaneously in the back of the neck.

[0032] 1.1 Drugs and reagents:

[0033]Kiskinin is obtained by the applicant of the present invention by extracting, separating and purifying the natural plant Gelkins, with a purity > 98.5% (accurately weigh kelkinin, dissolve it with 1mol / l HCl, dilute with physiological saline, adjust the pH with 1mol / l NaOH (4 <pH<7), diluted with physiological saline to the solution required for each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Lysine-pirin freeze-dried powder for injection (9g / bottle, the active ingredient is aspirin), Shanghai Xinya Pharmaceutical Co., Ltd., batch number H31020058. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0034] 1.2 Animals:

[0035] Kunming mice, male, 18-22g, provided by the E...

Embodiment 2

[0051] The analgesic effect of kelezin subcutaneously administered on the plantar side of formalin injection on chronic pain in mice.

[0052] 2.1 Drugs and reagents:

[0053] Kiskinin is obtained by the applicant of the present invention by extracting, separating and purifying the natural plant Gelkins, with a purity > 98.5% (accurately weigh kelkinin, dissolve it with 1mol / l HCl, dilute with physiological saline, adjust the pH with 1mol / l NaOH (4 <pH<7), diluted with physiological saline to the solution required for each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Indomethacin freeze-dried powder injection, SIGMA company, batch number 115K0689. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0054] 2.2 Animals:

[0055] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were rais...

Embodiment 3

[0070] The analgesic effect of formalin injection contralateral plantar subcutaneous administration of kelezin on chronic pain in mice.

[0071] 3.1 Drugs and reagents:

[0072] Kiskinin is obtained by the applicant of the present invention by extracting, separating and purifying the natural plant Gelkins, with a purity > 98.5% (accurately weigh kelkinin, dissolve it with 1mol / l HCl, dilute with physiological saline, adjust the pH with 1mol / l NaOH (4 <pH<7), diluted with physiological saline to the solution required for each dosage group.) formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0073] 3.2 Animals:

[0074] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at room temperature at 25°C under a light-dark cycle of 12 / 12h, free to eat and drink, and used for formal experiments after 3 days of adaptation to the laboratory.

[0075] 3.3 Method:

[0076] 20 mice ...

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Abstract

The invention discloses the application of koumine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the koumine on chronic pains of animals prove that the koumine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the koumine is much higher than that of the total alkaloids of gelsemium, the koumine possibly has no tolerance, no addiction and little side effect, which indicates that the koumine has potent and low-toxicity analgesic effect, the mechanism of action of the koumine is possibly different from those of clinically common opium analgesics or aspirin analgesics, the koumine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and the like, has no tolerance and addiction and little side effect, thus the koumine has bright industrialization prospect.

Description

technical field [0001] The invention relates to the application of koumine alkaloid monomers, in particular to the application of koumine in the preparation of medicines for treating chronic pain. Background technique [0002] Severe acute and chronic pain plagues tens of millions of patients, among which chronic pain is the most common and the most serious. There are two main types of chronic pain: inflammatory pain and neuropathic (neuropathic) pain. In my country, 20% to 30% of patients have a history of chronic pain, 35% in the United States, and 29% in Canada. The average course of the disease is about 10.7 years. Chronic pain is not only frequent and persistent, but also seriously affects the work and life of patients. Drug analgesia is currently one of the main means of clinically treating pain in patients, among which opioid analgesics such as morphine and antipyretic, analgesic and anti-inflammatory drugs such as aspirin are the most commonly used. At present, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P29/00A61P25/04
Inventor 俞昌喜许盈刘浩
Owner FUJIAN MEDICAL UNIV
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