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Applications of hexa-gelsemicine in preparing medicament for treating chronic ache

A technology of chronic pain and active ingredients, which is applied in the field of application of kelezin in the preparation of drugs for the treatment of chronic pain, to achieve the effect of strong analgesic effect, effective chronic pain and clear industrialization prospects

Active Publication Date: 2011-08-31
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There are no literature and patent reports about the anti-chronic pain effect of kelezin and its possible use

Method used

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  • Applications of hexa-gelsemicine in preparing medicament for treating chronic ache
  • Applications of hexa-gelsemicine in preparing medicament for treating chronic ache
  • Applications of hexa-gelsemicine in preparing medicament for treating chronic ache

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Analgesic Effect of Gelkinin by Subcutaneous Injection on the Back of the Neck on Formalin-Induced Chronic Pain in Mice

[0030] 1.1 Drugs and reagents:

[0031] Kelsin has been extracted, isolated and purified from the natural plant Gelkins, with a purity of >98.5% (accurately weighed Kelsin, dissolved in 1mol / l HCl, diluted with normal saline, and adjusted to pH with 1mol / l NaOH (4<pH <7), diluted with physiological saline to the solution required for each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Lysine-pirin freeze-dried powder for injection (9g / bottle, the active ingredient is aspirin), Shanghai Xinya Pharmaceutical Co., Ltd., batch number H31020058. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0032] 1.2 Animals:

[0033] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical Universit...

Embodiment 2

[0049] The analgesic effect of kelezine subcutaneously administered to the plantar side of formalin injection on chronic pain in mice

[0050] 2.1 Drugs and reagents:

[0051] Kelsin has been extracted, isolated and purified from the natural plant Gelkins, with a purity of >98.5% (accurately weighed Kelsin, dissolved in 1mol / l HCl, diluted with normal saline, and adjusted to pH with 1mol / l NaOH (4<pH <7), diluted with physiological saline to the solution required for each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Indomethacin freeze-dried powder injection, SIGMA company, batch number 115K0689. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0052] 2.2 Animals:

[0053] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at room temperature at 25°C under a light-dark cy...

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Abstract

The invention discloses the application of gelsenicine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the gelsenicine on chronic pains of animals prove that the gelsenicine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsenicine is much higher than that of the total alkaloids of gelsemium, the gelsenicine possibly has notolerance, no addiction and little side effect, which indicates that the gelsenicine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsenicine is possibly different from those of the clinically common opium analgesics or aspirin analgesics. The gelsenicine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains, have no serious disadvantages of the clinically common analgesics, and can be developed into a novel analgesic which has potent analgesic effect on treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsenicine has bright industrialization prospect.

Description

technical field [0001] The present invention relates to the application of Gelsenicine alkaloid monomer, in particular to the application of Gelsenicine in the preparation of medicine for treating chronic pain. Background technique [0002] Severe acute and chronic pain plagues tens of millions of patients, among which chronic pain is the most common and the most serious. There are two main types of chronic pain: inflammatory pain and neuropathic (neuropathic) pain. In my country, 20% to 30% of patients have a history of chronic pain, 35% in the United States, and 29% in Canada. The average course of the disease is about 10.7 years. Chronic pain is not only frequent and persistent, but also seriously affects the work and life of patients. Drug analgesia is currently one of the main means of clinically treating pain in patients, among which opioid analgesics such as morphine and antipyretic, analgesic and anti-inflammatory drugs such as aspirin are the most commonly used. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/439A61P29/00A61P25/04
Inventor 俞昌喜许盈刘浩
Owner FUJIAN MEDICAL UNIV
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