64results about How to "Increase fibrinolytic activity" patented technology

The invention belongs to the technical field of drinks and discloses fermented soybean milk, fruit juice soymilk and a preparation method of the fermented soybean milk and the fruit juice soymilk. The method comprises the following steps of: preparing raw soybeans, sequentially performing sorting, washing, soaking, cooking, beating, separating and filtering treatments on the raw soybeans, homogenizing, sterilizing, cooling to the temperature of 40-45 DEG C, and adding lactic acid bacteria and milk sugar for fermenting in 12-16 hours to obtain the fermented soybean milk; and on the basis of taking the raw soybeans, the lactic acid bacteria, the milk sugar, sugar, a thickening agent, a sweetener, milk, nattokinase, fruit juice, acid, buffer salt, essence and water as raw materials, preparing the fermented soybean milk, mixing, performing a constant volume process, blending, homogenizing, sterilizing and cooling to obtain the fermented soymilk. According to the invention, the amount of the soybean beany flavor in the product is reduced by 80-90%, the fruit juice is added to the soybeans so as to complement each other and enable the taste to be blander and delicate, in addition, the nattokinase is added to the soymilk, so that the nutrition of the product can be improved; the product can be placed at a room temperature for 6 months with stable state, no bleeding and a deposition rate of less than 1%.

An application of the Chinese medicine 'Superfine Tongxinluo' in relaxing the vascular endothelial injury caused by atherosclerosis, decreasing the cardiac infarction range after AMI reperfusion, preventing hyperlipemia and atherosclerosis, and treating arteria coronaria spasm, pile, thromboangiitis obliterans, platelet coagulation, etc is disclosed.

This invention discloses a thrombolytic zyme gene, a recombination protein and its preparation method relating to a thrombus dissolving material, relating to a source strain of thrombus dissolving gene and two reorganized strains containing said gene. Study shows that the zyme is a new plasmin and its vitality is 41000IUmg computed by the fibrin panel method having the function of anti-damage and suppressing protein oxidation arisen from beam, NaNO2 and H2O2.

The invention discloses a Radix Puerariae tea and a preparation method thereof. The preparation method comprises the following steps: 1, cleaning wild Radix Puerariae, and removing skin and root; 2, cleaning and purifying Radix Puerariae skin and Radix Puerariae root, and drying them; 3, crushing into powder, and stirring and mixing the power, guar gum, xanthan gum and a proper amount of water to uniformity; 4, allowing the obtained material to stand, and carrying out granulation molding on the obtained material in a mixing granulator; 5, carrying out high temperature frying in a tea frying machine; 6, cooling, and sprinkling an aqueous solution of vitamin C to the obtained cooled material; and 7, carrying out low temperature vacuum drying and weighing packaging to obtain the Radix Puerariae tea. By optimizing a formula and a technology in the invention, the prepared Radix Puerariae tea which has a stable quality has the efficacies of heat clearing and alcohol effect relieving, blood fat reducing, blood pressure reducing, blood sugar reducing and the like. In addition, the preparation method which treats the Radix Puerariae skin and the Radix Puerariae root as raw materials provides technological supports for fully utilizing Radix Puerariae resources, increasing values of the Radix Puerariae tea and reducing wastes.

The invention relates to a disease preventing and curing medicinal mouth-muffle and a medicinal composite. The disease preventing and curing medicinal mouth-muffle (1) comprises a mouth-muffle body (2), one surface of the mouth-muffle body (2) is provided with an insert pocket (3), and a powder bag (4) which packages the medicinal composite is placed in the insert pocket (3). The medicinal composite comprises the following Chinese herbs by weight: 2.2 percent of chrysanthemum and muskiness, 4.2 percent of cinnamon, good ginger, long pepper, radix aconite, frankincense, myrrh and clove, 5.0 percent of vermilion, 6.4 percent of asarum, eaglewood, croton, resina draconis, early plum flowers and rhizoma ligustici wallichii and 7.6 percent of tooth soap, arsenic sulphide and brain sand. The disease preventing and curing medicinal mouth-muffle internally carries the medicinal composite which plays a role during the mouth-muffle wearing process, thereby having disease prevention and cure and being simple and direct and also effective in treatment.

The invention relates to a new application of pseudo-ginseng, pseudo-ginseng extract, panax notoginseng saponins, and panax notoginseng saponins composite, namely, a new application in preparing medicament for curing and / or preventing diabetic microangiopathies.

The invention provides a garlic saponin liposome, comprising the following components in parts by weight: 1 part of garlic saponin, 10-100 parts of phospholipid, 1-50 parts of cholesterol and 0-50 parts of emulsifier, wherein the garlic saponin liposome can be prepared by such conventional methods as film dispersion method, ultrasonic dispersion method and reverse evaporation method, for example, injection method, freeze drying method, etc. The garlic saponin liposome can be prepared to a plurality of formulations, for example, tablet, capsule, oral liquid, injection, aerosol or drop and the like, and the garlic saponin liposome is applied to preparation of drugs for preventing bacteria, reducing cholesterol, reducing blood fat, preventing platelet aggregation, improving fibrinolytic activity, preventing hypoxia and preventing oxidative damage, etc.

This invention discloses a natto kinase, its coding gene and its application, in which, said natto kinase is a protein including one of the sequences of the following amino acid residues, 1), SEQ ID No: 1in the list, 2), the amino acid residue sequence of the SEQ ID No:1 in the list is replaced, deleted and added by 1-10 amino acid residues and has fibrinolysis activity. The expression method is to set up a secretory expression carrier of colibacillus with the natto kinase gene to be introduced into a colibacillus to get a re-structured colibacillus to be induced to express the natto kinase gene, which has high fibrinolysis activity.

The invention discloses a drug for treating rheumatoid arthritis. The drug is prepared from radix aconiti kusnezoffi preparata, radix aconiti preparata, radix angelicae, asarum, lumbricus, rhizoma arisaematis, flos carthami, yam rhizome, semen coicis, radix angelica sinensis, placenta and ants according to a proper ratio. The medicines are ground into fine powder, and the fine powder is coated with raw honey to form pellets. Due to the fact that the toxicity of the formula is high, the drug needs to be stopped for two days to observe the pharmacodynamic function after being used for one week. The drug has a remarkable curative effect for rheumatoid arthritis, especially when clinical manifestations include symmetrical pain and swelling of multiple joints in the whole body, symmetrical stiffness or tightness of joints, even deformation to different degrees, alternate chills and fever, limb joint and muscular ache, unsmooth flexion and extension, or unstable pain, and even severe pain, swelling, hardness and deformation of joints. Treatment of 200 patients confirmed through blood and modern medical equipment proves that 166 patients are cured, 11 patients are improved, the effective rate is 88.5%, and the cure rate is 83%.

Bacilliis natto NLSSc with the preservation number CGMCC No. 0724 is Gram staining positive, non-acid fast, straight or near straight, (0.6-0.8)x(1.5-2.0) micron sized and aerobic; has mesial and un-swelled spore with the spore number inside one sporange cell not more than one, meso diamino heptane diacid and glycin contained in the cell wall, no characteristic saccharum and peripheral flagellum; and can be grown well in five kinds of natural organic culture medium and can form relatively thick mycoderm and butter fat colored colony with smooth edge in soybean cake powder culture medium. Bacilliis natto can be cultured in culture medium with nitrogen source to obtain thrombus dissolving matter natto kinase and the cultured matter may be extracted to obtain powdered matter as the additive for thrombolytic health food.

The invention discloses a medicinal composition for treating stroke diseases, and a preparation thereof. The medicinal composition is a pure traditional Chinese preparation prepared through using ginseng, safflower, peach seed, Radix Paeoniae Rubra and lumbricus. Tests prove that the medicinal composition has the efficacies of qi tonifying, blood circulation promoting, stasis removing and collateral dredging, and is suitable for patients suffering from stroke diseases, especially qi deficiency and blood stasis strokes.

The invention discloses a hirudo small peptide effective part composition for treating diabetes and complications thereof, and belongs to the field of traditional Chinese medicines. The composition consists of hirudo small peptides extracted from hirudo, radix astragali total saponins extracted from radix astragali, fructus lycii total polysaccharides extracted from fructus lycii, and cornus officinalis total glycosides extracted from cornus officinalis according to a certain proportion, pharmaceutical conventional accessories are added to obtain various dosage forms, and the composition can be clinically used for preventing or treating diabetes and complications thereof.

The invention discloses a drug for preventing or treating cardiovascular and cerebrovascular diseases, which is made of a plurality of natural active pharmaceutical ingredients in weight account as follows: persimmon clayx 25 to 30 shares, haw 5 to 15 shares, danshen root 5 to 10 shares, Rhizoma Gastrodiae 5 to 15 shares, notoginseng 5 to 10 shares, Lobed Kudzuvine Root 5 to 12 shares, tuber fleeceflower 5 to 15 shares, fruit of common flowering quince 1 to 6 shares and hairy deerhorn 0.5 to 2 shares. The invention has good therapeutic effect on various types of cardiovascular and cerebrovascular diseases that the blood vessel can be effectively rinsed and softened; the thrombus is defreezed; the formation of thrombosis and platelet aggregation are inhibitted; the blood viscosity is improved; the blood lipid dredging and fluency are activated; the aging cardio-cerebrovascular is renewedly vigorous; the normal supply of heart is maintained; the blood pressure decreased steadily; the blood lipid is clear; the blood sugar is decreased; the whole human body is powerful and full of energy. The clinical experiment of prior patient shows that in the condition of no recurrence in five years, the cure rate is more than ninety six percent, and the cure rate of thick blood lipid patient is more than ninety nine percent. The drug has the advantages of significant effect and no recurrence.

The invention discloses a pharmaceutical composition and its preparation containing rhizoma arisaematis for treating stroke. The pharmaceutical composition is a pure Chinese material medical preparation prepared by rhizoma arisaematis, arisaema cum bile, uncaria, bulbus fritillariae cirrhosae and concha haliotidis. The tests prove that the pharmaceutical composition has efficacy of eliminating phlegm by cooling and inducing resuscitation, and is suitable for stroke paralytics, especially for phlegm-heat inner closed paralytics.

The invention discloses a new abbokinase modifier in the genetic engineering domain, which consists of KGD and RGDS, wherein the tPA K2 segment and abbokinase P area are induced to the N end of molecular structure, which is compatible with platelet aggregation inhibition.

The invention relates to application of a traditional Chinese medicine composition in preparing a medicine for reducing inflammatory reaction after PCI, which is prepared from the following bulk drugsby weight percentage: 22.2 to 66.8 % of radix astragali, 11.6 to 33.4 % of red sage root, 2.5 to 13.5 % of pseudo-ginseng, and 14.5 to 44.3 % of dalbergia heartwood.

The invention discloses a peach seed-containing medicinal composition for treating stroke diseases, and a preparation thereof. The medicinal composition is a pure traditional Chinese preparation prepared through using Chinese angelica, Radix Astragali, Radix Paeoniae Rubra, lumbricus and peach seed. Tests prove that the medicinal composition has the efficacies of qi tonifying, blood circulation promoting, stasis removing and collateral dredging, and is suitable for patients suffering from stroke diseases, especially qi deficiency and blood stasis strokes.

The invention discloses a Boswellia carteri-containing medicinal composition for treating stroke diseases, and a preparation thereof. The medicinal composition is a pure traditional Chinese preparation prepared through using Chinese angelica, Radix Astragali, Boswellia carteri, myrrh and lumbricus. Tests prove that the medicinal composition has the efficacies of qi tonifying, blood circulation promoting, stasis removing and collateral dredging, and is suitable for patients suffering from stroke diseases, especially qi deficiency and blood stasis strokes.

The invention discloses an instant food for reducing blood fat and a preparation method thereof. The instant food comprises the following components in parts by weight: 8-30 parts of red yeast rice, 6-28 parts of natto, 5-25 parts of black garlic, 5-30 parts of yeast, 5-30 parts of flaxseed, 5-20 parts of grape seed, 4-20 parts of pseudo-ginseng root, 3-12 parts of cordyceps militaris, 4-10 parts of red-rooted salvia root, 3-12 parts of barbary wolfberry fruit, 3-12 parts of pine pollen, 3-12 parts of mushroom, 4-10 parts of kelp and 3-10 parts of platycodon grandiflorum. The instant food has the functions of enhancing the fibrinolytic activity of blood, effectively lowering the blood fat and reducing hyperlipidemia complications.

An application of the Chinese medicine 'Superfine Tongxinluo' in relaxing the vascular endothelial injury caused by atherosclerosis, decreasing the cardiac infarction range after AMI reperfusion, preventing hyperlipemia and atherosclerosis, and treating arteria coronaria spasm, pile, thromboangiitis obliterans, platelet coagulation, etc is disclosed.

The invention discloses a pharmaceutical composition and its preparation containing polygala tenuifolia for treating stroke. The pharmaceutical composition is a pure Chinese material medical preparation prepared by polygala tenuifolia, rhizoma acori graminei, calculus bovis, musk, bamboo juice and uncaria rhynchophylla. The tests prove that the pharmaceutical composition has efficacy of eliminating phlegm by cooling and inducing resuscitation, and is suitable for stroke paralytics, especially for phlegm-heat inner closed paralytics.

The invention relates to the field of traditional Chinese medicine and pharmacy, in particular to a traditional Chinese medicine composition for treating ischemic stroke and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition consists of six medicines of raw milkvetch roots, dried rehamnnia roots, raw radix scutellariae, earthworms treated in wine, raw lobed ku-dzuvine roots, raw safflowers and the like. According to the traditional Chinese medicine composition, cerebral infarction volume can be reduced, neurological function damage canbe reduced, brain tissue MDA content can be reduced, and SOD activity is improved. The 6-keto-PGF1 alpha content is increased, and the TXB2 content is reduced. The traditional Chinese medicine composition has the effects of resisting free radical damage, resisting thrombosis and improving fibrinolytic activity, and effects of thrombolysis and dethrombosis. Compared with Naoxintong and other contrast inventions, the traditional Chinese medicine composition has notable protection effects on cerebral ischemia reperfusion damage; and compared with different dosage compounding ratios, the formula of the traditional Chinese medicine composition is more scientific. The experiment provides a reference for a mechanism for protecting cerebral ischemia reperfusion damage, and experiment data is provided for clinical application of the traditional Chinese medicine composition in the respect of cerebral vessels.

The invention provides a garlic saponin liposome, comprising the following components in parts by weight: 1 part of garlic saponin, 10-100 parts of phospholipid, 1-50 parts of cholesterol and 0-50 parts of emulsifier, wherein the garlic saponin liposome can be prepared by such conventional methods as film dispersion method, ultrasonic dispersion method and reverse evaporation method, for example, injection method, freeze drying method, etc. The garlic saponin liposome can be prepared to a plurality of formulations, for example, tablet, capsule, oral liquid, injection, aerosol or drop and the like, and the garlic saponin liposome is applied to preparation of drugs for preventing bacteria, reducing cholesterol, reducing blood fat, preventing platelet aggregation, improving fibrinolytic activity, preventing hypoxia and preventing oxidative damage, etc.

The invention discloses a medical composition for treating apoplexy containing borneol and a preparation thereof. The pharmaceutical composition of the present invention is a pure traditional Chinese medicine preparation made of dannanxing, tangerine peel, bezoar, musk, borneol, cinnabar, and calamus. Tests have proved that the pharmaceutical composition has the effects of clearing away heat, resolving phlegm, refreshing the mind and resuscitating the mind, and is suitable for apoplexy Especially stroke patients with phlegm-heat internal closure type.

The invention provides rhizoma dioscoreae bulbiferae enzyme wine and a production process thereof. The rhizoma dioscoreae bulbiferae enzyme wine is prepared from raw materials, medicinal materials and rhizoma dioscoreae bulbiferae enzyme powder, wherein the raw materials comprise sorghum and sticky rice; the medicinal materials comprise red dates, fructus lycii, saffron crocus and radix astragali seu hedysari. According to the rhizoma dioscoreae bulbiferae enzyme wine provided by the invention, medicine liquid and the rhizoma dioscoreae bulbiferae enzyme powder are added in a raw material fermentation process; the rhizoma dioscoreae bulbiferae enzyme powder is fermented in wine mash, so that harmful infectious microbes in wine liquid can be reduced, yeast proliferation can be stimulated, reducing sugar can be effectively utilized and the wine yield is improved. The rhizoma dioscoreae bulbiferae enzyme powder can enable the wine liquid to contain probiotics and the health-care effect is improved. Rhizoma dioscoreae bulbiferae enzyme is added into the wine liquid for fermentation treatment; bioactive components contained in the rhizoma dioscoreae bulbiferae enzyme can influence active enzymes in a body of a user and can be used for regulating vital movement of the body from a cell level; the enzyme has very good effects of regulating the immunity and a sleeping state, detoxifying and beautifying, alleviating constipation, growing and blackening hair and improving a detoxifying function of liver.

The invention discloses a medicinal composition for treating apoplexy containing antelope horn and its preparation. The pharmaceutical composition of the present invention is a pure traditional Chinese medicine preparation made from Gastrodia elata, antelope horn, Fangfeng, notopterygium, and Ophiopogon japonicus. Clinical trials have proved that the pharmaceutical composition of the present invention has the effects of cooling the liver and quenching wind, benefiting yin and dredging collaterals, and is suitable for apoplexy Diseases, especially the treatment of patients with yin deficiency and wind movement syndrome.

The present invention relates to one kind of lumbricus kinase of electrophoretical purity and the lumbricus kinase is extracted from Chiziaisheng lumbricus and may be used in treating ischemic cerebral vascular diseases. The lumbricus kinase as one kind of proteinase is prepared via ion exchange chromatography, ultrafiltering and gel filtering to desalt. It has electrophoretical purity and may be used as the material of freeze dried powder for injection and medicine liquid for intravenous injection. The lumbricus kinase of the present invention has low toxicity and high fibrinolytic activity, and is safe and effective.

The present invention discloses an ntelope horn-containing stroke treatment drug composition and a preparation thereof. The drug composition is a pure traditional Chinese medicine preparation prepared from tall gastrodia rhizome, ntelope horn, divaricate saposhnikovia, incised notopterygium rhizome and root, and creeping liriope. Clinical trial results prove that the drug composition has effects of liver calming-wind stopping, phlegm dissipating and collateral dredging, and is suitable for treatment of stroke, particularly stirring wind due to deficiency of yin.

The invention discloses a traditional Chinese medicine formula for treating cerebral hemorrhage with cardiovascular and cerebrovascular obstruction. The traditional Chinese medicine formula for treating the cerebral hemorrhage with the cardiovascular and cerebrovascular obstruction is prepared from the following raw materials of 140-180g of pseudo-ginseng, 130-160g of red sage root, 140-170g of gastrodia elata, 120-160g of hawthorn, 130-180g of Chinese angelica, 120-160g of ligusticum wallichii, 6-30g of safflower, 20-80g of white peony root, and 30-60g of Chinese yam. The traditional Chinese medicine formula for treating the cerebral hemorrhage with the cardiovascular and cerebrovascular obstruction is good in treatment effect, good in absorption effect and capable of achieving anticoagulation, inhibiting platelet aggregation, increasing fibrinolytic activity, reducing blood viscosity, inhibiting in-vivo platelet activation during cerebral ischemia, relieving vascular smooth muscle spasm, expanding blood vessels, increasing cerebral blood flow, improving microcirculation and reducing oxygen consumption.