40results about How to "Improve sleep disorders" patented technology

The invention discloses a sleep-improving enzymolysis substance rich in aromatic amino acid, and a preparation method for the sleep-improving enzymolysis substance. The preparation method comprises the following steps of: mixing casein and distilled water at a mass ratio of 1:8-15, carrying out preprocessing heating, stirring and dispersion, regulating pH, adding one or multiple proteases at a proper temperature, carrying out enzymolysis for 0.5-4h, after enzyme deactivation is carried out, cooling to the room temperature, carrying out low-temperature centrifugation, taking supernate, and carrying out concentration and spray drying to obtain a finished product. By use of the sleep-improving enzymolysis substance prepared by the preparation method disclosed by the invention, a composition peptide of which the N terminal is the aromatic amino acid is obviously higher than other common casein enzymolysis substances, wherein tryptophan serves as a neurotransmitter serotonin precursor substance and is favorable for sleep, and peptide of which the N terminal is Tyr and Phe has calm activity. Through second-level mass spectrum identification peptide, the product disclosed by the inventionis rich in typical antianxiety peptide [alpha]-CZP and releases various antianxiety active and opioid active peptides, such as YL, FF and YPVEPF, can effectively assist in alleviating pressure and anxious emotion and eliminating sleep disorders.

The invention provides a healthy food, which is not a single factor and contains compound sleep nutrients, for solving sleep disorders and a preparation method of the healthy food. By adopting the healthy food, the sleep quality of the middle-aged and aged people is effectively ensured; melancholies of the middle-aged and aged people at night are relieved; senescence is delayed; and the living quality of the middle-aged and aged people is improved. The healthy food is formed by fermentation of natural edible plants and / or fruits as basic substrates through table vinegar, wherein the natural edible plants and / or fruits are selected from at least two of root of kudzu vine, cranberry, fructus hippophae, blackberry tea, tea leaves, black mulberry fruits, ginseng, polygonum multiflorum, semen sesami nigrum and gallnut.

The invention provides a nutrient composition capable of relieving pressure as well as a preparation method and application of the nutrient composition. The nutrition composition comprises the following components in parts by weight: 0.5-2 parts of vitamin C, 0.2-0.6 part of a vitamin B group, 0.1-0.5 part of vitamin E, 0.0005-0.002 part of vitamin D, 2-8 parts of magnesium, 2-8 parts of curcumin,2-8 parts of betaine, 2-10 parts of gamma-aminobutyric acid, 1-8 parts of tea leaf theanine, 30-50 parts of licorice roots, 2-10 parts of phosphatidyl serine, 2-8 parts of L-tyrosine and 15-35 partsof ginseng. The nutrient composition can relieve pressure symptoms from the respects of improving sleep, resisting weariness, resisting inflammation and the like, and supports the adrenal gland function from a nutritive layer. Relevant nutrient components can be complemented pointedly. Through cooperative promotion of functions of various nutrient components, the capacity of pressure resistance oforganisms can be strengthened, and the entire health of pressure resistance systems is realized.

The invention discloses a head cover-type acupuncture point stimulation device for treating depressive sleep disorder by using five-tone mind regulation. The device comprises a main body and a connecting buckle plate, wherein a width adjusting mechanism is connected to the middle part of the main body; two sides of the width adjusting mechanism are provided with a headgear mechanism which is closeto the main body; and the buckle plate is arranged at the middle part of the headgear mechanism. The head cover-type acupuncture point stimulation device for treating depressive sleep disorder keepsa certain distance between the head of a patient and an earmuff mechanism, the patient is connected to a mobile phone APP through a Bluetooth device fixing sleeve, the tunes corresponding to syndrometype are selected, the corresponding brain wave stimulation is carried out on the brain through the different tunes, after the choice of the tunes is finished, the selection of the pulse emitter therapy is carried out and includes time and strength, the pulse wave stimulation is carried out on the corresponding selected acupuncture points, the related brain area is excited, the recovery and the remodeling of the related nerves are promoted, the sleep disorder and the depression symptoms are improved, and the side effect of drugs can be obviously reduced while the effective therapy is carried out.

The invention provides functional sweets capable of relieving pressure and a making method of the functional sweets. The functional sweets comprise an nutrient composition and auxiliary materials, wherein the nutrient composition consists of the following components in parts by weight: 0.5-3 parts of a vitamin mixture, 2-10 parts of magnesium, 1-15 parts of calcium, 1-10 parts of gamma-aminobutyric acid, 1-10 parts of tea leaf theanine, 20-55 parts of licorice roots, 1-15 parts of phosphatidyl serine, 1-10 parts of L-tyrosine, 10-35 parts of ginseng, 1-15 parts of curcumin, and 1-15 parts of betaine, and the auxiliary materials are selectively added according to the type of the made sweets. The functional sweets can relieve pressure symptoms from the respects of improving sleep, resistingweariness, resisting inflammation and the like. Relevant functional components can be complemented pointedly, and through associated promotion of various nutrient functional components, the capacity of resisting pressure of organisms can be strengthened. The functional sweets can be used as sweets to be suitable for various crowds, have certain health-care efficacy, and conform to green and healthy diet view of modern consumers.

The invention provides an inactivated lactic acid bacteria inoculant as well as a preparation method and application thereof, and belongs to the technical field of microbial preparations. Two strainsof lactic acid bacteria, namely lactobacillus paracasei HYZQF3DS-2 and lactobacillus plantarum HYZQF1675-63, are obtained through screening and further mutagenesis treatment, the two strains of lacticacid bacteria are very suitable for thermal inactivation treatment, and fermentation process research is further carried out on the two strains of lactic acid bacteria, thereby improving the strain fermentation performance; and experiences prove that the microbial inoculum obtained after the fermentation culture of the two strains has good effects of relieving constipation and diarrhea; a meanwhile, the bacteria inoculant has the effects of improving sleep disorder, anxiety and the like, thereby having good practical application value.

The embodiment of the invention discloses compound essential oil for treating insomnia, and belongs to the technical field of medicines. The compound essential oil disclosed by the invention is compounded by plant essential oil and basic oil. Since adopted raw materials are pure natural substances, after the compound essential oil is used, the compound essential oil can be naturally discharged through own body fluid metabolism and has a small side effect. Clinical experiments prove that the compound essential oil has an obvious improvement effect for the insomnia caused by insufficiency of heart and spleen, heart-gallbladder qi deficiency, imbalance between heart-yang and kidney-yin, pathogenic fire caused by depression of the liver and phlegm-heat internal attacking, can improve the sleepquality of a patient and is worth being clinically prompted and applied.

The invention provides an intelligent sleep assistance system with transcranial magnetic stimulation. The system comprises a stimulation device arranged on the surface layer of the encephalic region,a scanning device capable of scanning the encephalic region and the stimulation device, a positioning device capable of positioning the stimulation device, a brain wave sensor capable of collecting abrain wave signal and a magnetic field generation device; the brain wave sensor is arranged on the surface layer of the encephalic region and connected with the magnetic field generation device, the magnetic field generation device is connected with the stimulation device, the scanning device is connected with the positioning device, and the positioning device is connected with the magnetic fieldgeneration device. According to the intelligent sleep assistance system with transcranial magnetic stimulation, the technical problems are solved that in the prior art, through precise orienteering stimulation of the target encephalic region, it is difficult to intelligently identify different states of the brain wave of the human body for achieving the sleep assistance function, and when orienteering stimulation on any encephalic region is achieved according to stimulation demands, it is difficult to dynamically adjust the frequency and intensity of the magnetic field for achieving the sleepassistance function according to the real-time state of the brain wave.

The invention discloses a mind tranquilizing and sleep helping food and a preparation method thereof and belongs to the technical field of health foods. The mind tranquilizing and sleep helping food comprises the following raw materials: seabuckthorn seeds, spina date seeds, humulone, tuckahoe, mulberries, magnesium orotate and fungus powder; after tuckahoe is added into a humulone organic extract, the humulone organic extract is mixed with an organic extract of the seabuckthorn seeds and the spina date seeds, the mulberries and magnesium orotate are added into an obtained mixture, the funguspowder is added into the mixture to be fermented for 3-5 d after mixing, and then a fermentation product is dried to obtain a finished product. The mind tranquilizing and sleep helping food contains multiple biological active components capable of improving sleeping; the content of vitamin B6 and 5-hydroxytryptamine is obviously increased; the effects of calming, tranquilizing mind and promoting sleep are realized; and by using an antidepressive therapy method, sleep disorders are fundamentally improved, the sleeping quality is improved, and the sleeping time is prolonged.

The invention discloses collagen protein powder contributing to sleep. The collagen protein powder contributing to sleep is prepared by mixing raw materials of 0.1g-10g of gamma-aminobutyric acid, 0.1g-12g of a Lvliang red jujube extract, 0.1g-12g of a spina date seed extract, 100ug-10mg of B2, and 99.6999g-65.99g of collagen protein powder. The collagen protein powder can reduce the nerve cell activity, restrain anxiety information from being transmitted to brain centers, calm nerves and resist anxiety, has the effects of stabilizing and calming spirit, can notably improve the sleep situation, and is particularly suitable for people with poor sleep condition to eat.

The invention provides an application of albiflorin or pharmaceutically acceptable salts of albiflorin to preparation of human melatonin system function improving products. Albiflorin or the pharmaceutically acceptable salts of albiflorin serving as an endogenous melatonin secretion accelerant and a melatonin receptor stimulant can be used for preparing drugs, food, health care products, food additives or nutritional supplements for improving and treating sub-health statuses and / or diseases caused by melatonin system dysfunction, wherein the sub-health statuses are selected from one or more of biological rhythm disorder type sleep disorder, senile sleep disorder, affective disorder, cognitive disorder and immune system dysfunction; the diseases are selected from one or more of depression, anxiety disorder, Alzheimer's disease and Parkinson's disease.

The invention relates to phenol tea acid and a preparation method and application thereof; the preparation method comprises: adding 5 mmol of dihydromyricetin into 20 ml of methyl alcohol, dissolving for 30 min, placing the dissolved solution in an ice cell, titrating 5.5 mmol of piperidine into the dihydromyricetin methyl alcohol solution in the presence of argon at -10 DEG C, placing for 20 min so that reaction is thorough, evacuating, concentrating reaction liquid under the air pressure decreased by 20%, filtering, and washing three times with methyl alcohol to obtain the phenol tea acid; the phenol tea acid is useful as a therapeutic drug for treating Alzheimer disease and other nervous / nervous system progressive degenerative changes; the phenol tea acid is a compound potentially effective in preventing and treating Alzheimer disease; the phenol tea acid is effective in improving anxiety disorder, cognitive disorder, sleep disorder, and cognitive, learning and memory ability functional degradative symptoms in other forms due to various reasons; the phenol tea acid has a following structural formula.

The invention discloses a health-care food with function of improving sleep and a preparation method thereof and belongs to the technical field of health-care foods. The health-care food is prepared from the following traditional Chinese medicinal materials in parts by weight: 480-720 parts of schisandra chinensis, 360-540 parts of spina date seed, 2-90 parts of salvia miltiorrhiza 190, 120-180 parts of ginseng and 240-360 parts of Chinese date. The health-care food keeps to guidance of the traditional Chinese medicine theory, accords with the insomnia improvement thinking in modern medicine, obeys the strict code standard according to the requirements of the modern health-care food, is safe, effective, stable, controllable in quality and convenient to take, and is a new generation health-care food with a modern dosage form. The efficacy validation experiment proves that the health-care food has a good calming and hypnotizing function, the autonomic activity frequency of a mouse can be obviously reduced, the incubation period of falling asleep for the mouse can be obviously shortened, and the sleep time of the mouse is prolonged.

Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cornus officinalis, the chemical formula is C17H26O10, and the molecular weight is 390.38. Animal experiments confirm that loganin can significantly prolong the total sleep time of mice, and has the characteristic of dose dependent increase of sleep amount. Preliminary action mechanism study shows that loganin possibly induces sleep by increasing the level of 5-HT in mouse brain. To sum up, loganin can be prepared into drugs and health care products with sedative and hypnotic effects, the made dosage forms include granules, tablets, capsules, granules, electuaries, oral liquid, dripping pills, pellets or injections.

The invention discloses a compound longan seed oral liquid, and a preparation method and application thereof, and provides a compound longan seed oral liquid with few side effects, an accurate curative effect and the efficacies of tranquilizing and allaying excitement and promoting sleep, and a preparation method and application thereof. Every 100 mL of the oral liquid contains 40 g of crude longan seeds and 8 g of crude spina date seeds. The preparation method of the oral liquid comprises the following steps: using longan seeds as a main raw material, and preparing a longan seed water extract through water soaking, decoction, filtration and concentration; using spina date seeds as an auxiliary raw material, and preparing a spina date alcohol extract through degreasing, 70% ethyl alcohol reflux extraction, filtration and concentration; mixing the longan seed water extract and the spina date alcohol extract according to the crude drug mass ratio of 5:1, preparing a supernatant through centrifugation, and preparing the compound longan seed oral liquid by a conventional method. The oral liquid provided by the invention uses the longan seeds and spina date seeds as raw materials, and has the efficacies of tranquilizing and allaying excitement and promoting sleep, and has an accurate curative effect and few side effects. The preparation method is simple and suitable for large-scale production.

Provided are a cervical physiological curve correction cushion and a manufacturing method thereof. The correction cushion comprises a cushion sleeve and fillers in the cushion sleeve. The fillers are composed of, by weight, 3-5 parts of agilawood powder, 3-5 parts of sandalwood powder, 4-10 parts of pterocarpus santalinus powder and 30-40 parts of tartary buckwheat hull. Containing bags with traditional Chinese medicine such as agilawood powder and pterocarpus santalinus powder are arranged in the cushion sleeve, the containing bags are connected with the cushion sleeve through connecting belts, and the containing bags can be arranged in the fillers. The correction cushion can treat and prevent various cervical vertebra diseases, has a good improving effect on sleep disorders and solves the problem in the existing correction cushion (medicine pillow) that the service life is short, toxicity can be generated if the cushion is used for a long time, and cushion cores are required to be replaced. A preventing and treating effect can be kept for a long time, and the traditional Chinese medicine components in the containing bags are slowly released to further prolong the service life. Components are simple and easy to prepare, and the cushion is especially suitable for people who sit in front of computers to work for a long time and have poor sleeping quality.

The invention relates to medicinefor treating cardiac neurosis. The medicine is prepared from, by weight, 6 parts of fructus aurantii, 11 parts of prepared rehmannia roots, 8 parts of fructus gardeniae preparatus, 15 parts of tuber fleeceflower stems, 12 parts of danshen roots, 8 parts of rhizoma corydalis, 9 parts of Chinese dodder seeds and 7 parts of radix polygalae. According to the medicine,the fructus aurantii is used for regulating qi, dredging internal energy, removing stasis and dissipating swelling; the prepared rehmannia roots are used for nourishing yin, supplementing blood, boosting essence and replenishing the marrow; the fructus gardeniae preparatus is used for cooling blood for hemostasis; the tuber fleeceflower stems are used for tranquillizing mind by nourishing the heart, dredging collaterals and dispelling wind; the danshen roots are used for removing stasis, relieving pain, activating blood to promote menstruation, clearing away heart-fire and relieving restlessness; the rhizoma corydalis is used for invigorating blood circulation, tonifying qi and relieving pain; the Chinese dodder seeds are used for nourishing the liver and kidney, securing essence, arresting polyuria, improving eyesight and checking diarrhea; the radix polygalae is used for calming nerves, developing intelligence, eliminating phlegm and removing swelling. All the medicinal materials arecombined to be used and jointly achieve the effects of promoting qi and blood circulation, tonifying the kidney, receiving yang and tranquillizing mind by nourishing the heart. Clinical experiments indicate that by means of the medicine, cardiac neurosis can be treated safely and effectively.

The invention provides application of heme in medicine, food and healthcare food which are capable of improving sleep disorders, and specifically provides the application of the heme, a derivative thereof, an analogue thereof, a solvate thereof or pharmaceutically acceptable salt thereof. The heme, the derivative thereof, the analogue thereof, the solvate thereof and the pharmaceutically acceptable salt thereof are used for preparing a medicine composition, a preparation, the food or the healthcare food, and the medicine composition, the preparation, the food or the healthcare food can be used for (a) treating or improving the sleep disorders and (b) improving symptoms related to the sleep disorders.

The invention belongs to the technical field of medicines, and discloses non-starch lily polysaccharide NSLP-1 and application thereof. The non-starch lily polysaccharide NSLP-1 is separated and extracted from lily, and has effects of inflammation resistance, intestinal flora disorder regulation and control, and sleep disorder improvement, and provides a natural and novel drug source for development of prevention or treatment of intestinal flora disorder or diseases induced by intestinal flora disorder.

The invention discloses earthworm polypeptide health-care wine and a preparation technology, and relates to the technical field of health-care wine. The health-care wine comprises the following components in weight ratio: 85 to 90 percent of Baijiu, 1.5 to 2.5 percent of earthworm polypeptide, 2 to 3 percent of rehmannia glutinosa, 2 to 3 percent of ostrea gigas thunberg, 1 to 1.5 percent of platycladus orientalis, 1 to 1.5 percent of ziziphus jujube, and 1 to 1.5 percent of asini corii colla, wherein the alcohol content of the Baijiu is greater than 55 percent; the earthworm polypeptide is an earthworm protein extract. An earthworm polypeptide component with the effect of sleep improvement is extracted from an earthworm material through the technologies of flash extraction, bienzyme hydrolysis, ozone deodorization and ultrafiltration, and is prepared into the health-care wine with obvious efficacy and small side effects through the combination with the traditional Chinese medicine components having the effect of sleep improvement, such as the rehmannia glutinosa, the ostrea gigas thunberg, the platycladus orientalis, the ziziphus jujube and the asini corii colla; and the health-care wine can effectively improve dyssomnia, and is suitable for most of crowds, high in practicability, practical, safe and reliable.

The invention relates to the technical field of health-care tea, and discloses after-moxibustion tea capable of lowering lung qi and astringing mind and a preparation method of the after-moxibustion tea. The citrus tea comprises citrus reticulata blanco shells and a composition capable of lowering lung qi and astringing mind, The composition for reducing lung qi and astringing mind is prepared from 5-15 parts of acanthopanax, 5-15 parts of schisandra chinensis, 5-10 parts of radix puerariae, 5-10 parts of liquorice and 50-100 parts of tea leaves. The citrus tea has the effects of tranquilizing and allaying excitement, replenishing qi to invigorate the spleen, astringing lung qi and relieving cough and asthma, has the faint scent of the pericarpium citri reticulatae and tea, is sour, sweet and delicious, and can promote salivation after being drunk. All the medicinal components of the citrus tea are natural Chinese herbal medicines, artificially synthesized components are not added or are hardly added, and the components are non-toxic, so that the citrus tea is more suitable for long-term drinking as health-care tea. The tea is particularly suitable for being drunk in a matched mode after moxibustion, and lung qi hot dryness easily generated after moxibustion of people with some physiques is avoided.

The invention provides an antagonist composition and application of the antagonist composition in preparation of a medicine for treating sleep disorder and mental disease. The antagonist composition comprises a CRH receptor antagonist and a glutamic acid energy receptor antagonist. The invention firstly discovers that the sleep duration / stability and fear reaction degree of REM can be changed by regulating and controlling the activity of neurons of corticotropin releasing hormone of the subthalamic nucleus or neurons of a globular pallidum area on the outer side of the downstream of the subthalamic nucleus, which indicates that the subthalamic nucleus and the cerebral area of the downstream of the subthalamic nucleus are functional regulation and control targets for coincidence of sleep disorder and dysfear-related mental diseases. The invention also finds that the subthalamic nucleus CRH neuron and the glutamic acid energy neuron have a very high coincidence ratio for the first time. Based on the above findings, the present invention combines a CRH receptor antagonist with a glutamic acid receptor antagonist to regulate CRH and glutamic acid signal transmission of subthalamic nucleus-lateral globular pallidum, thereby improving sleep disorders and mental disorder comorbidity associated with fear mood disorder.