426results about How to "Drug resistance" patented technology

The invention discloses an antibacterial masterbatch, nano antibacterial super-tough plastic added with an antibacterial masterbatch and preparation and an application of the plastic and relates to the technical field of high molecular materials. The nano antibacterial super-tough plastic is characterized by being prepared from the following raw materials in parts by weight through blending and extruding: 70-93 parts of resin, 2-10 parts of antibacterial masterbatch, 5-20 parts of a flexibilizer, 0.1-1.0 part of an antioxidant and 0.2-1.0 part of a lubricant. The preparation method comprises the following steps: firstly, preparing the antibacterial masterbatch, then, weighing the raw materials in proportion, adding into a high speed mixer and mixing for 2-10 minutes; and then, extruding and granulating the obtained mixture through a twin-screw extruder to obtain the nano antibacterial super-tough plastic. The nano antibacterial super-tough plastic disclosed by the invention has an efficient, lasting, broad-spectrum and safe antibacterial effect, can be applied to preparation of spectacle frames and can satisfy the requirements on characteristics of the spectacle frames such as great elasticity, strong toughness and difficulty in breakage.

The invention relates to a hydrogen sulfide treating agent for oil fields and a method for treating hydrogen sulfide. The invention belongs to the technical field of hydrogen sulfide treatment in oil and gas fields. The hydrogen sulfide treating agent for oil fields is characterized by comprising the following components in percentage by weight: 10 to 45 percent of nitrate, 5 to 50 percent of nitrite, 5 to 10 percent of water soluble microorganism activating system, and 45 to 80 percent of water. The method for treating hydrogen sulfide with the hydrogen sulfide treating agent for oil fields comprises: to treat hydrogen sulfide in oil reservoirs, adding the hydrogen sulfide treating agent into injected water, namely injecting the hydrogen sulfide treating agent into a water pipe according to an injection concentration of 100 to 1,500 mg / L to mix the hydrogen sulfide treating agent with the injected water, and injecting the mixture into a stratum by a water injection pipe; and to treat hydrogen sulfide in a production system, adding the hydrogen sulfide treating agent in produced liquid and gas, namely injecting the hydrogen sulfide treating agent into a production system according to an injection concentration of 100 to 1,500 mg / L to mix the hydrogen sulfide treating agent with the produced liquid and gas. The hydrogen sulfide treating agent has the advantages of treating hydrogen sulfide generated by different factors, improving recovery rate of oil fields, along with convenience for construction, quick effectiveness, low cost, safety, no toxin, environmental friendliness and the like.

The invention relates to a compound plant-derived pesticide, which is prepared by mixing the following components in percentage by weight: 2-5% of nicotine, 2-5% of wild mugwort oil, 3-8% of cinnamon leaf oil, 5-10% of litsea cubeba oil, 30-40% of flavescent sophora root mixed ethanol extract, 10-15% of Rangoon creeper fruit mixed water extract, 15-20% of emulsifying agent, 1-2% of sodium dodecylsulfate and the balance of water, wherein the flavescent sophora root mixed ethanol extract is obtained by extracting 3 parts by weight of flavescent sophora root, 1 part by weight of triperygium wilfordii, 2 parts by weight of toosendan fruit, 2 parts by weight of hellebore, 2 parts by weight of szechuan aconite, 1 part by weight of cnidium fruit and 1 part by weight of camphor tree seed with 70wt% ethanol solution, and has the relative density of 1.02-1.10; and the Rangoon creeper fruit mixed water extract is obtained by extracting 1 parts by weight of groundsel and 2 parts by weight of Rangoon creeper fruit with water solution, and has the relative density of 1.02-1.10. The compound plant-derived pesticide overcomes the limitations that the most plant derived pesticides are single in pest-killing components and simple in action mechanism, improves the comprehensive prevention and control effect, is quick in acting and long in duration, and avoids the generation of pest pesticide resistance.

The invention discloses a method for improving soil fertility of a greenhouse and preventing a soil disease. The method comprises a biogas slurry storage step, a soil anaerobic fermentation raw material sowing step, a step of conducting soil tillage on evenly-scattered anaerobic fermentation raw materials, a step of conducting flood irrigation on a cultivated filed through the biogas slurry and water, a step of covering a mulching film for sealing, a step of depressing the greenhouse, and a step of uncovering the mulching film to again conduct soil tillage. The method has no chemical composition residuals, can not damage strain balance of various beneficial bacteria in the soil, does not enable the beneficial bacteria to produce drug resistance, is stable in disinfection effect, can play a role of disinfecting on a deeper soil layer, is low in disinfection cost, can be used in a certain area in large-quantity and high-strength modes, solves the problem that biogas slurry consumption in a biogas project is difficult, improves soil physical and chemical properties and acid-base equilibrium, improves disease-insect resistance of the crop and stress resistance of a bad condition, can kill harmful bacteria, reduces the disease, improves absorption efficiency of the crop on various fertilizer components, improves fertilizer efficiency of the fertilizer and saves fertilizing cost.

A Chinese veterinary medicine in the form of injectino for treating infections diseases of livestock and fowls is prepared from 8 Chinese-medicinal materials including honeysuckle flower, forstyhia fruit, coptis root, phellodendron bark, etc through decocting in water and refining for removing impurities (tannin, protein, starch, resin, etc). Its advantages are high cure rate (more than 98%), no toxic by-effect, and no recurrence.

The invention discloses fruit and vegetable pesticide residue degradation equipment and method based on a water magnetization and electrolysis technology. The equipment comprises a magnetized and electrolysed water producing device and a degradation equipment body, wherein the degradation equipment body comprises a chain conveyor, a plurality of fruit and vegetable placement cages suspended below a rail of the chain conveyor at equal intervals as well as acidic potential water tank sets, alkaline potential water tank sets and pure water tanks which are sequentially arranged below the rail; the magnetized and electrolysed water producing device is connected with the acidic potential water tank sets and the alkaline potential water tank sets through liquid conveying pipes respectively; a plurality of slow descending platforms corresponding to the acidic potential water tank sets, the alkaline potential water tank sets and the pure water tanks are further arranged on the rail. By means of the characteristics of magnetized and electrolysed water, pesticide residues on fruits and vegetables can be degraded rapidly and efficiently, and the equipment is environment-friendly and reliable in the degradation process and is very suitable for large-scale degradation of fruit and vegetable pesticide residues.

The invention belongs to the field of pharmaceutic preparation, and relates to a targeted drug-carrying liposome of a tumor associated fibroblast. The surface of the targeted drug-carrying liposome is modified with a high-affinity ligand of a specific expression protein of the tumor associated fibroblast. The targeted drug-carrying liposome is capable of realizing targeted delivering of drugs into the tumor associated fibroblast, realizing intervention on tumor microenvironment via action on the tumor associated fibroblast, and realizing tumor treatment. And in addition, the tumor associated fibroblast targeted preparation can be combined with routine tumor cell targeted nano preparations so as to improve antitumous effects of the routine tumor cell targeted nano preparations.

The invention provides a culture method for tiger frogs, and particularly relates to the field of aquaculture. The culture method includes the steps of frog pond construction, specifies selection and spawning, tadpole culture, froglet and adult frog feeding and disinfection management. By improving the quality of culture water and adjusting a feed formula, technical problems caused by large density, poor water quality and improper feeding in artificial culture of tiger frogs are solved, the immunity of tiger frogs is effectively improved, the morbidity of tiger frogs is reduced, and the survival rate of tiger frogs in artificial culture is increased.

A Chinese veterinary medicine for treating infections Fabricius capsulitis of chicken is prepared from 17 Chinese-medicinal materials including honeysuckle flower, forsythia fruit, scutellaria root, red sage root, etc through crushing, decocting, concentrating, and mixing with gypsum powder. Its advantages are high cure rate (more than 96%), no generation of drug resistance for bacteria, and no recurrence.

The present invention discloses a compound scutellaria injection for curing infectious diseases in livestock and poultry, characterized in that the injection is prepared from the following raw materials with the weight portions: 10 to 50 portions of scutellaria, 30 to 100 portions of radix bupleuri, 30 to 100 portions of honeysuckle, 30 to 100 portions of cordate houttuynia, 30 to 100 portions of dyers woad root, 30 to 100 portions of Daqing leaf, 10 to 15 portions of tween 80 and 10 to 15 of benzyl alcohol; and the water for injection is appropriately confected to 1,000. The present invention is a pure Chinese medicine injection with quick effect, high curing effect, rare recurrence after cure and no drug resistance of bacteria. The present invention with no side effect on livestock and poultry and safe use has the curing rate of virus and bacterial infectious diseases in poultry up to 95 percent and of toxic epidemic diseases and bacterial diseases in other livestock up to 82 percent.

The invention provides a traditional Chinese medicine prepration for treating avian nephropathogenic infectious bronchitis, and the active ingredients thereof are prepared by the following raw materials according to the mixture ratio by weight: 80-120 parts of heartleaf houttuynia herb, 60-100 parts of tatarian aster root, 50-70 parts of perilla leaf, 40-60 parts of sea-ear shell, 40-60 parts of cassia seed, 35-60 parts of swordlike atractylodes rhizome, 30-60 parts of platycodon root, 30-50 parts of airpotato yam rhizome, 30-50 parts of oriental stephania root, 30-50 parts of rhubarb, 30-50 parts of membranous milkvetch root, 30-50 parts of tangerine peel, 30-40 parts of lightyellow sophora root, 20-40 parts of liquoric root, 20-40 parts of cape jasmine fruit, 20-40 parts of turmeric root-tuber, 20-40 parts of Sanxian and 20-40 parts of Chinese gentian. The medicine can effectively treat the avian nephropathogenic infectious bronchitis, the cure rate is more than 90 percent, and the medicine has difficult recurrence, obvious effect, convenient administration, no toxicity or side effects, safe use and low price. Bacteria have difficulty generating the drug resistance by using the medicine, thereby avoiding the occurrence of veterinary drug residues and social public harms.

An eka-cecropinA-magainin heterozygous gene engineering antibacterial peptide is prepared by adopting No.1-7 amino acid residue on N end of cecropinA CA and No.2-12 amino acid residue on N end of magainin M, design synthesizing heterozygous peptide CA(1-7)-M(2-12) gene by codon, connecting with carrier pPICZ alpha-A, mutating by point mutation technology to obtain mutant pPICZ alpha-CA-Mu-1, pPICZ alpha-CA-Mu-2 and pPICZ alpha-CA-Mu-3, converting SMD1168, and expressing CecA-Mag heterozygous antibacterial peptide to make into use under alcohol hydrogenase starter regulation.

The invention discloses a housefly cecropin-human lysozyme fusion protein, and a preparation method and application thereof. A sequence of the housefly cecropin-human lysozyme fusion protein of the invention is shown by SEQ ID No.1. The housefly cecropin-human lysozyme fusion protein comprises a mature peptide sequence of housefly cecropin, a polypeptide linker sequence and the mature peptide sequence of human lysozyme. The housefly cecropin-human lysozyme fusion protein is prepared by the following steps of: according to the gene sequences of the housefly cecropin and the human lysozyme, designing a synthetic primer with esherichia coli preferred codons; performing PCR amplification by using a splicing overlap extension method to obtain the gene sequence of the fusion protein so as to construct recombinant prokaryotic expression plasmids; transferring the recombinant prokaryotic expression plasmids into host cells to obtain engineering bacteria expressing the fusion protein; and performing fermentation culture, separation and purification to obtain the housefly cecropin-human lysozyme fusion protein of the invention. The fusion protein of the invention has the characteristics of the housefly cecropin and the human lysozyme per se, has relatively more remarkable antibacterial activity and antibiotic activity, can be used for preparing antibacterials or bacteriostatic medicaments, and has wide application prospect.

The invention relates to a biocontrol strain Y-1 for preventing and controlling fungal diseases of grapes and application of the biocontrol strain Y-1 in prevention and control of grape diseases and belongs to the technical field of biological prevention and control of plant diseases. The strain is Meyerozyma guilliermondii Y-1 with a preservation number of CCTCC (China Center For Type Culture Collection) NO:M2015814. The Meyerozyma guilliermondii Y-1 is used for preparing a biocontrol preparation for preventing and controlling the grape diseases, and the biocontrol preparation has an obviousprevention and control effect on multiple pathogenic fungi. The Meyerozyma guilliermondii Y-1, provided by the invention, as an active ingredient of the biocontrol preparation, has the characteristicsof stable prevention and control effect, long persistence and wide disease control spectrum as well as has the properties of environment friendliness, safety and low possibility of generating pesticide resistance; the strain has high propagation speed, is cultured under simple culture conditions and is easy for storage and industrial production; defense related enzyme activity in plant bodies canbe improved, and a good development and application prospect is realized.

A group of two vegetative insecticides A and B for preventing and eliminating armyworm, aphis, borer, red spider, cabbage caterpillar, etc and promoting the growth of agricultural crops is prepared from flavescent sophora rhizome, false hellebore and the flower bud of liliae daphne. Its preparing process is also disclosed.

The invention discloses a Rhodopseudomonas strain. The name of the Rhodopseudomonas strain is Rhodopseudomonas PSB-06, and the collection number is CCTCC NO:M2012518. The invention also discloses a biocontrol microbial inoculum which is obtained through the activation, seed culture and production culture of the strain. The preparation of the biocontrol microbial inoculum comprises the multiple steps of activation, seed culture and production culture. The invention also discloses a Rhodopseudomonas strain biocontrol fermentation liquid which is prepared from the biocontrol microbial inoculum through fermentation and centrifugation. Each of the Rhodopseudomonas strain, the biocontrol microbial inoculum and the biocontrol fermentation liquid can be used in antagonizing phytophthora capsici or controlling phytophthora blight of pepper.

A composite insecticide contains Bacillus thuringienis, muscardine and nimbin, and is prepared from the gemma of Bacillus thuringienis and muscardine, and nim seed powder through proportionally mixing.

The invention discloses a feed additive capable of replacing antibiotics and application of the feed additive. The feed additive is prepared from the following raw materials in weight percent: 10 % to 20% of glyceryl monolaurate, 20% to 40% of didansylhistamine, 30% to 60% of glycerin monostearate and 0 to 40% of a carrier. The feed additive provided by the invention is prepared by taking the glyceryl monolaurate, the didansylhistamine and the glycerin monostearate as the main raw materials and compounding according to a proper ratio and can replace the antibiotics in a piglet cultivation process; the disease-resisting capability of piglets is improved, the development of intestinal tracts is promoted and the functions of the intestinal tracts are improved; the daily gain and feed intake are remarkably improved, the diarrhea rate and the death and culling rate are remarkably reduced, the feed conversion ratio is improved, the growth and development are promoted, the economic benefits of cultivation are improved, the utilization of the antibiotics is reduced, the environment pollution is reduced, and the green, safe and healthy development of a pig industry is facilitated.

The invention discloses essential oil for cleaning and caring female private parts and a preparation method of the essential oil, aiming at the problems that the existing products are complicated and inconvenient to use, and not obvious in effect and long in treatment cycle, easily cause injuries or secondary infection of the private parts, and have abundant using contraindication, and consumers can have serious problems due to improper use. The essential oil is prepared from the following components in percentage by weight: 10-15% of lavender spike essential oil, 17-22% of palmarosa essential oil, 12-20% of tea tree essential oil, 18-23% of clary sage essential oil, 10-15% of leptospermum scoparium essential oil, 10-15% of eucalyptus essential oil, and 4-9% of thujanol thyme essential oil. By utilizing the characteristics that the plant essential oil has the excellent antibacterial, antiviral, antimicrobic, sterilization and inflammation-diminishing efficacies, the principle that the plant essential oil has the volatility, the characteristic that the plant essential oil with complicated components can not have drug resistance like antibiotics, as well as the characteristic that that the essential oil has more curative effects through scientific mixing, the essential oil provided by the invention has the advantages of obvious effect and rapidness in taking effect.

The invention relates to a chiral graphene quantum dot.The chiral quantum dot nano material is a single-layer graphene quantum dot modified with chiral amino acid.The chiral graphene quantum dot has the advantages that the chiral graphene quantum dot has the antibacterial property and is not prone to cause bacterial drug resistance, capable of selectively killing bacteria and free of toxicity to mammalian cells; the chiral graphene quantum dot is good in stability and water solubility and low in cost; the chiral graphene quantum dot has a novel chiral optical signal.

The invention belongs to the field of artificial feeds, relates to an artificial feed for the suzukii fruit bat fly, and in particular relates to synthesized feed used for artificial propagation of the suzukii fruit bat fly. The artificial feed takes mashed banana and apple as main components, and yeast powder as an auxiliary material. After the feed adopting the ratio is used for feeding the suzukii fruit bat fly, the suzukii fruit bat fly has the survival rate, the pupation rate, the eclosion rate and the isofemale egg laying amount approximate to those of the suzukii fruit bat fly fed by the natural feed, and the male and female average pupal weight is higher than the suzukii fruit bat fly fed by the natural feed, so that powerful condition is provided for normal supply of the suzukii fruit bat fly.

The invention provides a pesticide composition containing chitosan oligosaccharide. The pesticide composition comprises active constituents, namely chitosan oligosaccharide and any one or combination of emamectin benzoate, dichlorphos, beta-cypermethrin, dipterex, abamectin, phoxim and lorsban in addition to one or more of a dispersing agent, a wetting agent, an anti-freezing agent, a stabilizing agent, a preservative, a thickening agent, an emulsifying agent, a de-foaming agent, a solvent and a carrier. The invention further discloses a pesticide of the pesticide composition containing chitosan oligosaccharide and an application of the pesticide. The pesticide composition can be processed into missible oil, a suspending agent, water dispersible granules, a microemulsion, soluble powder and granules by adopting a general method in the field.

The invention relates to an endophytic bacterial agent for promoting cucumber growth and preventing fusarium wilt of cucumber, which is prepared by bacillus subtilis. The technical scheme adopted by the endophytic bacterial agent is as follows: mother solution is prepared by 0.7 to 2.0% of peptone, 0.3 to 1.0% of yeast extract, 0.5 to 1.0% of NaCl and the rest percent of water; then, the mother solution with the pH value of 5 to 9 is cultivated for 24 to 72 hours in oscillating and fermenting manners at the speed of 120 to 200r / min under the fermentation temperature of 20 to 32 DEG C according to the liquid volume of 25 to 55% and the inoculum size of 2 to 10%.

The invention relates to a plant insect-expelling biological fermentation solution. The plant insect-expelling biological fermentation solution is prepared from 2 to 4 parts of chili, 2 to 4 parts ofgarlic, 2 to 4 parts of onion, 2 to 4 parts of coriander, 2 to 4 parts of herba artemisiae annuae and the like. The plant insect-expelling biological fermentation solution provided by the invention has the beneficial effects that the plant insect-expelling biological fermentation solution is a pure plant natural insect-expelling agent, does not contain other chemical additives, is safe and has notoxin; the plant insect-expelling biological fermentation solution can be used for effectively expelling and killing almost insects, the insects do not easily have drug resistance and the plant insect-expelling biological fermentation solution is harmless to the environment.

The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.

The invention belongs to the pesticide field, which more particularly relates to a biological botanic insecticide and a preparation technique. The prescription of the biological botanic insecticide is as follows by weight percentage: 0.2-0.6 percent of abamectin; 1.0-3.0 percent of matrine; 3.0-3.5 percent of tripterygium wilfordii; 2.0-2.5 percent of rhododendron molle; 3.0-4.0 percent of grapeleaf anemone; 2.0-3.5 percent of unbracteolated spurge root; 2.5-4.0 percent of derris; 2.5-4.0 percent of stemona; 2.0-3.0 percent of vervain; 1.5-2.5 percent of emulsilier; 0.1-0.3 percent of antiseptic; 2.0-4.0 percent of stabilizing agent; and 65.0-88.2 percent of distilled water. The invention integrates stomachtoxicity, tag and nerve poison into one body. The invention not only has synergistic effect each other, improves the insecticidal efficiency and leads the harmful insect to be difficult to generate drug resistance, but also achieves the target of high efficiency and broad spectrum; the invention is harmless to the plant, has no residue with safe usage, therefore, the environment can be free from contamination.

The present invention discloses a combination of Chinese medicines for poultry and the preparation method and application. Hypericum forsythia and bidens grass are distilled. And then distilled liquid and residua are collected. The residua and the residual liquid after distillation being added with a hepatitis grass and a climbing nightshade are decocted three times. The decoction liquid is combined and concentrated to a thick concentration. A 95 percent ethanol is diluted to alcohol concentration of 60 percent to 70 percent. The drug liquid after sedimentation, filtration and concentration added with 95 percent ethanol are transferred to alcohol concentration of 75 percent to 80 percent and then are sedimentated and filtrated. The filtrate is concentrated. The drug liquid added with distilled water is frozenly precipitated, filtrated and concentrated. The combination of Chinese medicines is produced out after a combination of the distilled liquid of the hypericum forsythia and the bidens and the decoction liquid of the hepatitis grass and the climbing nightshade are combined. The combination of Chinese medicines has a cure rate of about 90% for a viruses and bacterial infectious disease of poultry, can be used to prepare the animal drug for treating duck viral hepatitis and chicken newcastle disease and has little side effect, safe use and fast absorption.

The invention discloses an attractant for Asias halodendri, and an attraction method thereof. The attractant is composed of 90% of 5mug / mul essential oil of Elaeagnus angustifolia with flowers, 3% of 0.5mug / mul cis-3-hexen-1-ol and 7% of 0.5mug / mul trans-2-hexenal. The attraction method of the attractant comprises the steps of attraction core making from a preparation material, trap making, fieldtrapping and the like. The attractant for trapping Asias halodendri of the invention has the characteristics of nontoxicity, harmlessness, environmental protection, no pollution, no residual, safety to humans and animals, strong pertinence, no damages to natural enemies and beneficial insects, no causing of the drug resistance of pests, simple operation, and low trapping cost. The developed attractant of the invention can trap many adults in a short period of time to reduce the harm of the adults to Tetraena mongolica Maxim.

The invention relates to a method of treating a host animal to eliminate pathogenic cells. The method comprises the steps of administering to the host animal a hapten-carrier conjugate, administering to the host animal a TH-I biasing adjuvant, and administering to said host animal a ligand conjugated to a hapten herein the ligand-hapten conjugate is administered during the first cycle of therapy with the hapten-carrier conjugate. The invention also relates to the same method wherein the ratio of the hapten-carrier conjugate to the TH-I biasing adjuvant on a weight to weight basis ranges from about 1:10 to about 1:1.

The invention discloses an application of a feed additive in preparation of a laying hen feed for improving egg quality and egg laying capability. The feed additive includes, by weight, 10-45% of glycerol monolaurate, 10-30% of glycerol dilaurate, 30-50% of glycerol monostearate, and 0-20% of a carrier. In feed additive, the glycerol monolaurate, the glycerol dilaurate and the glycerol monostearate are combined together, so that the feed additive significantly improves the egg quality and improves the egg laying capability of a laying hen.