Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof

Abstract

The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a sodium alginate nanofiber medical dressing containing antibacterial ingredients of traditional Chinese medicine and a preparation method thereof. Background technique [0002] Sodium alginate is a natural polysaccharide mainly from algae plants, mainly composed of 1,4-β-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit), and The protein polysaccharide components in human extracellular matrix are similar; sodium alginate also has excellent characteristics such as wide source, good biocompatibility, controllable biodegradability and non-toxicity, and will not cause antigenic reaction; these characteristics make it It has great application potential in the field of medical dressings. [0003] Both proteoglycans (glucosaminoglycan (GAG)) and fibrin, the main components of the natural extracellular matrix in human tissue, have nanostructured components; studies ...

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Problems solved by technology

[0003] Both proteoglycans (glucosaminoglycan (GAG)) and fibrin, the main components of the natural extracellular matrix in human tissue, have nanostructured components; studies have shown that nanostructured medical materials facilitate cell adhesion and proliferation, and are more functional than micron-scale Therefore, nanofibers have high utilization value in the field of medical dressings; at present, the main method for preparing nanofibers is electrospinning; but because sodium alginate is an anionic polyelectrolyte, its molecular chain is rigid in aqueous solution and have worm-like extensions, pure alginate electrospinning is very difficult

[0004] Wound infection is a key factor affecting wound healing, and it is also an important cause of repeated wounds and even death of patients; therefore, as a good medical dressing, it should have good antibacterial properties; in order to obtain antibacterial properties, traditional medical dressings are generally used in medical dressings. Add a certain amount of antibiotics, or metal ions with antibacterial properties such as nano-silver; however, if the antibiotics are used for a long time, the bacteria will mutate and develop drug resistance, and most of the metal particles are heavy metals. Potentially harmful to human organs