81results about How to "Avoid tolerance" patented technology

The present invention pertains to the identification of moieties and methods of using the same for preventing tolerance to bronchodilators. More specifically, the present invention pertains to the identification of compositions and methods which are capable of preventing tolerance to beta2-adrenergic agonists. The methods and compositions according to the invention are also useful as analytical tools for functional studies and as combination therapeutic tools.

Inertial Measurement Units based on integrated designs to reduce alignment and assembly costs. Integration also leads to performance improvement, increased miniaturization and simplification as well as reduced cost. Also disclosed are gyroscopes and accelerometers that are identical, yet by their mechanization, can be made to act as separate sensors. Miniaturization and simplification is improved by combining instruments that can share a common member. Savings in space and complexity are also possible in the electronics when elements are shared.

The invention discloses a novel large-tonnage bridge girder erection machine and a construction method thereof. The novel large-tonnage bridge girder erection machine comprises a main frame structure composed of a bridge girder erection machine main girder, a main girder front-linkage straining beam, a main girder rear-linkage straining beam. The main frame structure is provided with a middle supporting device, a front auxiliary supporting device and a rear auxiliary supporting device which are sequentially connected. The novel construction method of the novel large-tonnage bridge girder erection machine includes a bridge girder erection machine via hole process, a via hole and girder erection conversion process, a bridge girder erection machine girder erection process, a girder erection and via hole conversion process, a normal girder erection and tail span conversion process, a variable span construction process, a small curved section construction process and a pack transferring construction process. The novel large-tonnage bridge girder erection machine achieves the purpose that a prefabricated bridge is mounted through the bridge girder erection machine under the conditions of a large span, a large tonnage, small curvature, various changes of the span and amplitude, frequent transferring and the like and has the advantages of being safe, efficient, easy to operate and maintain, good in stability, dispersed in construction load and the like.

Methods, including those for administering novel pharmaceutical compositions, dosage forms containing an opioid active pharmaceutical ingredient, are useful for treating pain, arthritic conditions and / or inflammation associated with a chronic condition, including pain from arthritis and inflammation.

The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elastic return of the secondary body (12) from the main body (10).

The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elastic return of the secondary body (12) from the main body (10).

Methods of the prophylaxis of the development of allergy in a patient at risk of sensitization to an antigen(s) or allergen(s) due to impaired gastrointestinal functions include administering a mast cell inhibitor, e.g., ketotifen, e.g., ketotifen fumarate. Methods for prophylactically treating, reducing, delaying or controlling gastrointestinal disorders include administering a mast cell stabilizer, e.g., ketotifen to a patient in need thereof. Pharmaceutical preparation, composition for use in methods described, are also disclosed. Also disclosed are methods of prophylaxis or treating gastrointestinal and esophageal inflammation, and methods for the prophylaxis of the development of additional allergies to a newly introduced substance in a patient with a preexisting allergy. Such methods include delivery of a mast cell stabilizer, e.g., ketotifen. Oral and topical administration are contemplated within the scope of the methods.

A rivet setting machine is provided. In another aspect, a linear displacement sensor directly senses and detects a position of a rivet-setting punch relative to a nosepiece of a rivet setting machine. A further aspect provides a control system and software instructions for sensing the relative position of a punch and nosepiece used by a programmable controller to determine and monitor a rivet setting position without use of a force sensor, motor current / voltage sensor, or a rotation sensor.

An optical lens head, an camera module, and an assembling method therefor, wherein the camera module comprises a photosensitive chip (23) and an optical lens head (10); said optical lens head (10) comprises a plurality of optical lenses (111); the assembly position of one of the optical lenses (111) is adjustable; each of the optical lenses (111) is black-lacquered and matte-treated; a connecting portion (1113), a light-beam entrance hole (1114) and a light-shielding portion (1115) are formed on the corresponding optical lenses (111), such that the individual optical lenses (111) can be successively and jointly assembled together, eliminating the need of a spacing ring, a diaphragm, a lens barrel and other structural components used in a conventional camera module, thereby improving manufacture precision, production yield and imaging quality of the camera module.

A hinge device capable of locking a buffer switch position comprises a movable hinge cup and a hinge joint arm, wherein the movable hinge cup and the hinge joint arm are in hinge joint connection. A buffer mechanism is arranged on the movable hinge cup, the hinge joint arm at least acts on the buffer mechanism when a hinge is closed, the buffer mechanism comprises a damper and a gland, the damper is arranged in a concave position of the movable hinge cup, the gland is arranged on the damper, and the damper can slide back and forth on the gland. A damp switch component is arranged on the gland in a rotating or swing mode, and the limiting and / or restoration of a buffering stroke of the damper are / is achieved by rotating or swinging the damp switch component when the hinge is opened and / or closed. The gland and / or the damp switch component are / is made of plastic having certain elasticity, a limiting part is arranged between the gland and the damp switch component, and the damp switch component achieves position locking and the limiting and / or the restoration of the buffering stroke of the damper through the limiting part. The hinge device capable of locking the buffer switch position has the advantages of being simple and reasonable in structure, reliable in performance, long in service life, low in manufacturing cost, fast and convenient to adjust and accurate and firm in locating.

A method of producing holes in a component, in particular of turbomachines, wherein each hole extends from a first, outer surface to a second, inner surface of the component and wherein the method has, for example, the following steps: producing a 3D model of the actual geometry of the component, at least for the region of the holes; adopting each hole on the basis of the actual geometry of the component; generating a production program for each individual hole. In this way, the process quality and with it the quality of the holes increases, because the offset of holes caused by component tolerances is avoided and the drilling funnels are formed according to specification. Furthermore, drilling defects on account of the offset of holes and / or cores can be avoided. Overlapping holes caused by component tolerances are likewise avoided.

A fine adjustment mechanism includes a connecting unit and a fine-tuning bolt having a bolt shaft and a bolt head. The bolt shaft has a threaded section rotatably engaged with the connecting unit, a non-threaded section between the threaded section and the bolt head, and an annular protrusion projecting outwardly and radially from an outer surface of the non-threaded section and spaced apart from the bolt head. A retaining unit is molded over the fine-tuning bolt and covers the annular protrusion and portions of the non-threaded section which are proximate to two opposite annular end surfaces of the annular protrusion. The fine-tuning bolt is rotatable relative to the retaining unit. The connecting unit is movable along the threaded section when the fine-tuning bolt is rotated.

In a method of operating an exhaust emission control device, the presence of an actual pressure loss of a particulate filter is determined, and a model pressure loss is determined as a function of a state variable. On the basis of the actual pressure loss and the model pressure loss a pressure quotient is determined and a condition of the particulate filter is ascertained in a diagnostic mode in response to the pressure quotient.

The present invention relates to the use of Ca2+ / CaM-dependent protein kinase II (CaMKII) inhibitors alone and in combination with opiate analgesics for treating pain, in particular chronic pain. Methods for reducing or reversing tolerance, dependence, and opioid-induced hyperalgesia are also provided.

Neurological disorders and diseases, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Down's syndrome, can be ameliorated or beneficially treated by administration of a formulation comprising an effective amount of a pyrone-indole derivative of formula (I)Ar—B—Ar′  (I)wherein AR represents an indole nucleus ring system:Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system:and each of B, R1, R2, R3, R4, R1′ and R2′ are as defined herein.

A fuel injector having a pressure booster whose booster piston separates a working chamber, which is continuously acted on with fuel by means of a pressure source, from a differential pressure chamber that can be pressure-relieved; a pressure change in the differential pressure chamber occurs via an actuation of a servo-valve whose control chamber can be pressure-relieved by an on / off valve that also opens or closes a hydraulic connection of the differential pressure chamber to a first return on the low-pressure side. In the deactivated state of the pressure booster, a first sealing seat seals a return on the low-pressure side off from a high-pressure region of the servo-valve, which region is comprised of the control chamber, a first hydraulic chamber, and a second hydraulic chamber.

A method of producing holes in a component, in particular of turbomachines, wherein each hole extends from a first, outer surface to a second, inner surface of the component and wherein the method has, for example, the following steps: (i) producing a 3D model of the actual geometry of the component, at least for the region of the holes; (ii) adapting each hole on the basis of the actual geometry of the component; and (iii) generating a production program for each individual hole. In this way, the process quality and with it the quality of the holes increases, because the offset of holes caused by component tolerances is avoided and the drilling funnels are formed according to specification. Furthermore, drilling defects on account of the offset of holes and / or cores can be avoided. Overlapping holes caused by component tolerances are likewise avoided.

An improved autovaccination method designed to prevent or treat various neoplastic diseases by inducing a systemic immune response against a tumor and its remote metastases, consisting of the induction of an immunogenic cell death in one or more targeted tumor sites with local radiation therapy, cryotherapy, heat, chemotherapy or various other treatments, followed by intratumoral / peritumoral injection of dsRNAs (poly-ICLC in particular) in the same tumor site.

A power source (30, 32) supply circuit (28) is provided in a communication system of protective headgear for supplying a communication system from a power source (30, 32) associated with the protective headgear. The supply circuit (28) includes a boost converter (44) for better utilization of the electric power supplied by the power source (30, 32). Protective headgear is provided with such a supply circuit (28) for supplying the protective headgear. A method is also provided for operating such a supply circuit (28).

A lubrication pump includes a housing defining a bore, an adjustable cylinder sleeve within the bore, and a piston slidably movable within the bore along a longitudinal axis of the bore. A connector may be drivingly interposed between a cam and the piston for driving the piston in reciprocating axial motion. The connector may have a coupling for engaging the piston, which may enable rotational engagement between the connector and the piston. The connector may have a roller for bearing engagement with the cam, which may enable the connector to rotate about the longitudinal axis relative to the housing as the connector moves axially within the bore. The cam may be laterally displaceable relative to the connector. The cylinder sleeve may be adjustable relative to the piston for varying lubricant fluid output flow. The cylinder sleeve and corresponding piston may be interchangeably disposed in the housing.

A linear motion module comprises a linear rail, a sliding block and balls. The sliding block is slidingly disposed on the linear rail and comprises a sliding block body, circulation elements and end caps. The inside of the sliding block body is configured with inner circulation grooves, the inner circulation groove and the rail groove constitute an inner circulation passage, and each of two sides of the sliding block body is configured with at least a circulation channel that corresponds to the inner circulation passage and penetrates through the sliding block body. Each of the circulation elements includes at least a circulation tube, and the opposite two circulation tubes are connected to each other to constitute an outer circulation passage. Each of the end caps is configured with at least two circulation guiding grooves, and the circulation guiding groove is connected to the inner and outer circulation passages.

The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing neuropathic pain and depression caused by toxicity, metabolism abnormality, trauma, compression, autoimmune abnormality, congenital / hereditary abnormality, infection, abnormally activated neuronal circuits, emotional stress, chemical imbalance, mental health disorder, or other causes in subjects in need thereof. The disclosed invention further relates to naturally occurring, synthetic and semi-synthetic multifunctional compounds that exhibit antidepressant and analgesic activity where said compound contains a pharmacologically inactive substance.

Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in mammals, including humans.

The present invention relates to novel pyrone-indole derivatives, pharmaceutical formulations containing them, and use of the compounds in the manufacture of Medicaments for treating or preventing various diseases.

The present invention relates to a pharmaceutical composition comprising a peptide of 5 to 50 amino acids which comprises the amino acid sequence NPFPTX1X2KRX3X4 (SEQ ID NO: 2) wherein X1, X2, X3, and X4 may be the same or different and each is an amino acid residue, wherein said composition is in a form suitable for a transbuccal administration and use thereof for preventing or treating pain.

The invention relates to a large-size special-shaped open caisson foundation construction method. The large-size special-shaped open caisson foundation construction method comprises the steps that foundation pit surveying and setting out are conducted, a site is leveled, an open caisson cushion layer is manufactured, and blade foot manufacturing is conducted; then a first open caisson section is prefabricated, an inner side scaffold and an outer side scaffold are erected on the inner side and the outer side of the well wall correspondingly, a formwork is mounted, and concrete is poured; afterthe first open caisson section reaches the design strength, in-well soil taking sinking is conducted; then a second open caisson section is prefabricated, an outer side scaffold is erected on the outer side of the well wall, an operation platform is erected at the top of the first open caisson section, and an inner side scaffold is erected on the operation platform; and the formwork is mounted, concrete is poured, after the second open caisson section is completed, in-well soil taking sinking is conducted, manufacturing sinking of the next open caisson section is conducted according to a manufacturing method of the second open caisson section, and finally open caisson bottom sealing is conducted. According to the open caisson construction method, the scaffold erecting, material using and erecting time can be saved.